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Related papers: PrimeKG-CL: A Continual Graph Learning Benchmark o…

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Biomedical knowledge is fragmented across siloed databases -- Reactome for pathways, STRING for protein interactions, ClinicalTrials.gov for study registries, DrugBank for drug vocabularies, DGIdb for drug-gene interactions, SIDER for side…

Databases · Computer Science 2026-03-19 Madhulatha Mandarapu , Sandeep Kunkunuru

Knowledge graphs (KGs) are an important tool for representing complex relationships between entities in the biomedical domain. Several methods have been proposed for learning embeddings that can be used to predict new links in such graphs.…

Artificial Intelligence · Computer Science 2026-05-12 Daniel Daza , Dimitrios Alivanistos , Payal Mitra , Thom Pijnenburg , Michael Cochez , Paul Groth

Motivation: Biomedical knowledge graphs (KGs) are crucial for drug discovery and disease understanding, yet their completion and reasoning are challenging. Knowledge Embedding (KE) methods capture global semantics but struggle with dynamic…

Artificial Intelligence · Computer Science 2025-07-23 Yitong Lin , Jiaying He , Jiahe Chen , Xinnan Zhu , Jianwei Zheng , Tao Bo

Knowledge graphs (KGs) are increasingly integrated with large language models (LLMs) to provide structured, verifiable reasoning. A core operation in this integration is multi-hop retrieval, yet existing systems struggle to balance…

Computation and Language · Computer Science 2026-04-22 He Cheng , Yifu Wu , Saksham Khatwani , Maya Kruse , Dmitriy Dligach , Timothy A. Miller , Majid Afshar , Yanjun Gao

Knowledge graph completion (KGC) aims to predict missing triples in knowledge graphs (KGs) by leveraging existing triples and textual information. Recently, generative large language models (LLMs) have been increasingly employed for graph…

Artificial Intelligence · Computer Science 2025-11-11 Yongkang Xiao , Sinian Zhang , Yi Dai , Huixue Zhou , Jue Hou , Jie Ding , Rui Zhang

Continual learning has emerged as a crucial paradigm for learning from sequential data while preserving previous knowledge. In the realm of continual graph learning, where graphs continuously evolve based on streaming graph data, continual…

Machine Learning · Computer Science 2024-08-20 Jianhao Guo , Zixuan Ni , Yun Zhu , Siliang Tang

Biological systems are governed by structured molecular interactions, where pathways, regulatory circuits, and functional gene relationships shape cellular behavior and disease progression. Much of this knowledge is naturally represented as…

Machine Learning · Computer Science 2026-05-26 Yuwei Xue , Sakib Mostafa , James Zou , Joseph Liao , Maximilian Diehn , Ash A. Alizadeh , Lei Xing , Md. Tauhidul Islam

Continual Learning (CL) aims to incrementally acquire new knowledge while mitigating catastrophic forgetting. Within this setting, Online Continual Learning (OCL) focuses on updating models promptly and incrementally from single or small…

Machine Learning · Computer Science 2025-12-19 Giovanni Donghi , Luca Pasa , Daniele Zambon , Cesare Alippi , Nicolò Navarin

In recent years, continual learning (CL) techniques have made significant progress in learning from streaming data while preserving knowledge across sequential tasks, particularly in the realm of euclidean data. To foster fair evaluation…

Machine Learning · Computer Science 2024-06-10 Tianqi Zhao , Alan Hanjalic , Megha Khosla

Multi-relational temporal graphs are powerful tools for modeling real-world data, capturing the evolving and interconnected nature of entities over time. Recently, many novel models are proposed for ML on such graphs intensifying the need…

Knowledge Graphs (KGs) have proven highly effective for recommendation systems by capturing latent item relationships, while recent integration of Large Language Models (LLMs) has further enhanced semantic understanding and addressed…

Information Retrieval · Computer Science 2026-05-11 Xinchi Zou , Tongzhenzhi Su , Jianjun Li , Yuan Fu , Chang Liu , Zhiying Deng , Zhiwei Shen

Understanding how small molecules perturb gene expression is essential for uncovering drug mechanisms, predicting off-target effects, and identifying repurposing opportunities. While prior deep learning frameworks have integrated multimodal…

Machine Learning · Computer Science 2026-01-01 Pascal Passigan , Kevin Zhu , Angelina Ning

Irregular data in real-world are usually organized as heterogeneous graphs (HGs) consisting of multiple types of nodes and edges. To explore useful knowledge from real-world data, both the large-scale encyclopedic HG datasets and…

Artificial Intelligence · Computer Science 2023-09-12 Yide Qiu , Shaoxiang Ling , Tong Zhang , Bo Huang , Zhen Cui

Knowledge graphs (KGs) are a powerful approach for integrating heterogeneous data and making inferences in biology and many other domains, but a coherent solution for constructing, exchanging, and facilitating the downstream use of…

Large Language Models (LLMs) have grown exponentially since the release of ChatGPT. These models have gained attention due to their robust performance on various tasks, including language processing tasks. These models achieve understanding…

Computation and Language · Computer Science 2025-08-11 Ali Sarabadani , Maryam Abdollahi Shamami , Hamidreza Sadeghsalehi , Borhan Asadi , Saba Hesaraki

Constructing domain-specific knowledge graphs from unstructured text remains challenging due to heterogeneous entity mentions, long-tail relation distributions, and the absence of standardized schemas. We present LEC-KG, a bidirectional…

Computation and Language · Computer Science 2026-03-02 Yikai Zeng , Yingchao Piao , Changhua Pei , Jianhui Li

Biomedical knowledge graphs (BKGs) have emerged as powerful tools for organizing and leveraging the vast and complex data found across the biomedical field. Yet, current reviews of BKGs often limit their scope to specific domains or…

Computation and Language · Computer Science 2025-01-23 Yuxing Lu , Sin Yee Goi , Xukai Zhao , Jinzhuo Wang

Large Language Models (LLMs) are being adopted at an unprecedented rate, yet still face challenges in knowledge-intensive domains like biomedicine. Solutions such as pre-training and domain-specific fine-tuning add substantial computational…

Biomedical knowledge graphs (KG) are heterogenous networks consisting of biological entities as nodes and relations between them as edges. These entities and relations are extracted from millions of research papers and unified in a single…

Artificial Intelligence · Computer Science 2022-11-11 Dattaraj J. Rao , Shraddha S. Mane , Mukta A. Paliwal

The paper introduces ExKG-LLM, a framework designed to automate the expansion of cognitive neuroscience knowledge graphs (CNKG) using large language models (LLMs). It addresses limitations in existing tools by enhancing accuracy,…

Artificial Intelligence · Computer Science 2025-07-09 Ali Sarabadani , Kheirolah Rahsepar Fard , Hamid Dalvand