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Biomedical knowledge graphs underwrite drug repurposing and clinical decision support, yet the upstream ontologies they depend on update on independent cycles that add millions of edges and deprecate hundreds of thousands more between…

Artificial Intelligence · Computer Science 2026-05-12 Yousef A. Radwan , Yao Li , Qing Qing , Ziqi Xu , Xingtong Yu , Jiaxing Huang , Renqiang Luo , Xikun Zhang

Real-world multimodal knowledge graphs (MMKGs) are dynamic, with new entities, relations, and multimodal knowledge emerging over time. Existing continual knowledge graph reasoning (CKGR) methods focus on structural triples and cannot fully…

Computation and Language · Computer Science 2026-04-06 Linyu Li , Zhi Jin , Yichi Zhang , Dongming Jin , Yuanpeng He , Haoran Duan , Gadeng Luosang , Nyima Tashi

Knowledge graphs (KGs) are an important tool for representing complex relationships between entities in the biomedical domain. Several methods have been proposed for learning embeddings that can be used to predict new links in such graphs.…

Artificial Intelligence · Computer Science 2026-05-12 Daniel Daza , Dimitrios Alivanistos , Payal Mitra , Thom Pijnenburg , Michael Cochez , Paul Groth

Biomedical Knowledge Graphs (BKGs) integrate diverse datasets to elucidate complex relationships within the biomedical field. Effective link prediction on these graphs can uncover valuable connections, such as potential novel drug-disease…

Computation and Language · Computer Science 2025-07-01 Tien Dang , Viet Thanh Duy Nguyen , Minh Tuan Le , Truong-Son Hy

Medical deep learning models depend heavily on domain-specific knowledge to perform well on knowledge-intensive clinical tasks. Prior work has primarily leveraged unimodal knowledge graphs, such as the Unified Medical Language System…

Artificial Intelligence · Computer Science 2025-05-26 Xiaochen Wang , Yuan Zhong , Lingwei Zhang , Lisong Dai , Ting Wang , Fenglong Ma

Continual learning (CL) aims to empower machine learning models to learn continually from new data, while building upon previously acquired knowledge without forgetting. As models have evolved from small to large pre-trained architectures,…

Machine Learning · Computer Science 2026-03-31 Dianzhi Yu , Xinni Zhang , Yankai Chen , Aiwei Liu , Yifei Zhang , Philip S. Yu , Irwin King

Clinicians are increasingly looking towards machine learning to gain insights about patient evolutions. We propose a novel approach named Multi-Modal UMLS Graph Learning (MMUGL) for learning meaningful representations of medical concepts…

Machine Learning · Computer Science 2024-02-07 Manuel Burger , Gunnar Rätsch , Rita Kuznetsova

Benefiting from the powerful expressive capability of graphs, graph-based approaches have achieved impressive performance in various biomedical applications. Most existing methods tend to define the adjacency matrix among samples manually…

Machine Learning · Computer Science 2021-07-02 Shuai Zheng , Zhenfeng Zhu , Zhizhe Liu , Zhenyu Guo , Yang Liu , Yao Zhao

Benefiting from the powerful expressive capability of graphs, graph-based approaches have been popularly applied to handle multi-modal medical data and achieved impressive performance in various biomedical applications. For disease…

Machine Learning · Computer Science 2022-03-14 Shuai Zheng , Zhenfeng Zhu , Zhizhe Liu , Zhenyu Guo , Yang Liu , Yuchen Yang , Yao Zhao

Large Language Models (LMs) are known to encode world knowledge in their parameters as they pretrain on a vast amount of web corpus, which is often utilized for performing knowledge-dependent downstream tasks such as question answering,…

Computation and Language · Computer Science 2022-05-25 Joel Jang , Seonghyeon Ye , Sohee Yang , Joongbo Shin , Janghoon Han , Gyeonghun Kim , Stanley Jungkyu Choi , Minjoon Seo

Multimodal Contrastive Learning (MCL) advances in aligning different modalities and generating multimodal representations in a joint space. By leveraging contrastive learning across diverse modalities, large-scale multimodal data enhances…

Machine Learning · Computer Science 2025-09-23 Xiaohao Liu , Xiaobo Xia , See-Kiong Ng , Tat-Seng Chua

Recent advances in natural language processing (NLP) owe their success to pre-training language models on large amounts of unstructured data. Still, there is an increasing effort to combine the unstructured nature of LMs with structured…

Computation and Language · Computer Science 2023-12-22 Juraj Vladika , Alexander Fichtl , Florian Matthes

Multimodal reasoning with large language models (LLMs) often suffers from hallucinations and the presence of deficient or outdated knowledge within LLMs. Some approaches have sought to mitigate these issues by employing textual knowledge…

Computation and Language · Computer Science 2024-06-06 Junlin Lee , Yequan Wang , Jing Li , Min Zhang

Continual learning (CL) aims to enable learning systems to acquire new knowledge constantly without forgetting previously learned information. CL faces the challenge of mitigating catastrophic forgetting while maintaining interpretability…

Computer Vision and Pattern Recognition · Computer Science 2025-04-01 Lu Yu , Haoyu Han , Zhe Tao , Hantao Yao , Changsheng Xu

Continual learning (CL) refers to the ability of an algorithm to continuously and incrementally acquire new knowledge from its environment while retaining previously learned information. A model trained on one data modality often fails when…

Machine Learning · Computer Science 2025-08-22 Nilay Kushawaha , Egidio Falotico

Recent years have seen a rapid growth of utilizing graph neural networks (GNNs) in the biomedical domain for tackling drug-related problems. However, like any other deep architectures, GNNs are data hungry. While requiring labels in real…

Biological Physics · Physics 2022-05-03 Mengying Sun , Jing Xing , Huijun Wang , Bin Chen , Jiayu Zhou

Continual learning in computer vision faces the critical challenge of catastrophic forgetting, where models struggle to retain prior knowledge while adapting to new tasks. Although recent studies have attempted to leverage the…

Computer Vision and Pattern Recognition · Computer Science 2025-03-25 Xusheng Cao , Haori Lu , Linlan Huang , Fei Yang , Xialei Liu , Ming-Ming Cheng

Motivation: Biomedical knowledge graphs (KGs) are crucial for drug discovery and disease understanding, yet their completion and reasoning are challenging. Knowledge Embedding (KE) methods capture global semantics but struggle with dynamic…

Artificial Intelligence · Computer Science 2025-07-23 Yitong Lin , Jiaying He , Jiahe Chen , Xinnan Zhu , Jianwei Zheng , Tao Bo

Large Language Models (LLMs) often suffer from hallucinations, which Retrieval-Augmented Generation (RAG) and GraphRAG mitigate by incorporating external knowledge and knowledge graphs (KGs). However, GraphRAG remains text-centric due to…

Artificial Intelligence · Computer Science 2026-03-11 Xueyao Wan , Hang Yu

Large language models (LLMs) offer new opportunities for constructing knowledge graphs (KGs) from unstructured clinical narratives. However, existing approaches often rely on structured inputs and lack robust validation of factual accuracy…

Artificial Intelligence · Computer Science 2026-01-06 Udiptaman Das , Krishnasai B. Atmakuri , Duy Ho , Chi Lee , Yugyung Lee
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