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In the field of pharmacokinetics and pharmacodynamics (PKPD) modeling, which plays a pivotal role in the drug development process, traditional models frequently encounter difficulties in fully encapsulating the complexities of drug…

Quantitative Methods · Quantitative Biology 2024-09-23 Nazanin Ahmadi Daryakenari , Shupeng Wang , George Karniadakis

In molecular research, the modelling and analysis of molecules through simulation is an important part that has a direct influence on medical development, material science and drug discovery. The processing power required to design protein…

Quantum Physics · Physics 2026-03-24 Prateek Jain , Param Pathak , Krishna Bhatia , Shalini Devendrababu , Srinjoy Ganguly

The longitudinal analysis of patient response time course following doses of therapeutics is currently performed using Pharmacokinetic/Pharmacodynamic (PK/PD) methodologies, which requires significant human experience and expertise in the…

Machine Learning · Computer Science 2021-06-24 James Lu , Brendan Bender , Jin Y. Jin , Yuanfang Guan

We present a novel Pharmacokinetic/Pharmacodynamic (PK/PD) model for the induction phase of anesthesia, incorporating the $\psi$-Caputo fractional derivative. By employing the Picard iterative process, we derive a solution for a…

Optimization and Control · Mathematics 2023-11-17 Mohamed Abdelaziz Zaitri , Hanaa Zitane , Delfim F. M. Torres

With the aim of establishing a framework to efficiently perform the practical application of quantum chemistry simulation on near-term quantum devices, we envision a hybrid quantum--classical framework for leveraging problem decomposition…

The fundamental question of how to best simulate quantum systems using conventional computational resources lies at the forefront of condensed matter and quantum computation. It impacts both our understanding of quantum materials and our…

Strongly Correlated Electrons · Physics 2021-09-29 Juan Carrasquilla , Di Luo , Felipe Pérez , Ashley Milsted , Bryan K. Clark , Maksims Volkovs , Leandro Aolita

The simulation of quantum dynamics on a digital quantum computer with parameterized circuits has widespread applications in fundamental and applied physics and chemistry. In this context, using the hybrid quantum-classical algorithm,…

Quantum Physics · Physics 2023-07-19 Tangyou Huang , Yongcheng Ding , Léonce Dupays , Yue Ban , Man-Hong Yung , Adolfo del Campo , Xi Chen

Quantum computing employs controllable interactions to perform sequences of logical gates and entire algorithms on quantum registers. This paradigm has been widely explored, e.g., for simulating dynamics of manybody systems by decomposing…

Quantum Physics · Physics 2025-05-21 S. Alipour , A. T. Rezakhani , Alireza Tavanfar , K. Mölmer , T. Ala-Nissila

This review discusses the current applications, advantages, and limitations of PBPK and PopPK models in radiopharmaceutical therapy (RPT). PBPK models simulate radiopharmaceutical kinetics by integrating prior physiological and drug…

Hybrid quantum-classical machine learning represents a frontier in computational research, combining the potential advantages of quantum computing with established classical optimization techniques. PennyLane provides a Python framework…

Software Engineering · Computer Science 2025-11-20 Sidney Shapiro

The advent of hybrid computing platforms consisting of quantum processing units integrated with conventional high-performance computing brings new opportunities for algorithm design. By strategically offloading select portions of the…

Quantum computers have the potential to simulate chemical systems beyond the capability of classical computers. Recent developments in hybrid quantum-classical approaches enable the determinations of the ground or low energy states of…

Quantum Physics · Physics 2021-12-06 Chee-Kong Lee , Jonathan Wei Zhong Lau , Liang Shi , Leong Chuan Kwek

We introduce a hybrid classical-quantum algorithm to compute dynamical correlation functions and excitation spectra in many-body quantum systems, with a focus on molecular systems. The method combines classical preparation of a perturbed…

Quantum Physics · Physics 2025-10-30 Alessandro Santini , Stefano Barison , Filippo Vicentini

Partial differential equations (PDEs) play a crucial role in financial mathematics, particularly in portfolio optimization, and solving them using classical numerical or neural network methods has always posed significant challenges. Here,…

Quantum Physics · Physics 2026-04-07 Letao Wang , Abdel Lisser , Sreejith Sreekumar , Zeno Toffano

Quantum transfer learning combines pretrained classical deep learning models with quantum circuits to reuse expressive feature representations while limiting the number of trainable parameters. In this work, we introduce a family of compact…

Medical images are characterized by intricate and complex features, requiring interpretation by physicians with medical knowledge and experience. Classical neural networks can reduce the workload of physicians, but can only handle these…

Computer Vision and Pattern Recognition · Computer Science 2025-01-14 Yangyang Li , Zhengya Qia , Yuelin Lia , Haorui Yanga , Ronghua Shanga , Licheng Jiaoa

The drug design process currently requires considerable time and resources to develop each new compound that enters the market. This work develops an application of hybrid quantum generative models based on the integration of parametrized…

Current quantum computing hardware is restricted by the availability of only few, noisy qubits which limits the investigation of larger, more complex molecules in quantum chemistry calculations on quantum computers in the near-term. In this…

Unlike most classical algorithms that take an input and give the solution directly as an output, quantum algorithms produce a quantum circuit that works as an indirect solution to computationally hard problems. In the full quantum computing…

Quantum Physics · Physics 2025-05-22 Yikai Mao , Shaswot Shresthamali , Masaaki Kondo

Quantum circuit simulations play a critical role in bridging the gap between theoretical quantum algorithms and their practical realization on physical quantum hardware, yet they face computational challenges due to the exponential growth…

Quantum Physics · Physics 2025-08-20 Ji-Hoon Kang , Hoon Ryu
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