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Predicting potential and counterfactual outcomes from observational data is central to individualized decision-making, particularly in clinical settings where treatment choices must be tailored to each patient rather than guided solely by…

Machine Learning · Statistics 2026-04-16 Dongze Wu , David I. Inouye , Yao Xie

We introduce DeCaFlow, a deconfounding causal generative model. Training once per dataset using just observational data and the underlying causal graph, DeCaFlow enables accurate causal inference on continuous variables under the presence…

Machine Learning · Computer Science 2025-10-27 Alejandro Almodóvar , Adrián Javaloy , Juan Parras , Santiago Zazo , Isabel Valera

Data-driven decision making frequently relies on predicting counterfactual outcomes. In practice, researchers commonly train counterfactual prediction models on a source dataset to inform decisions on a possibly separate target population.…

Machine Learning · Statistics 2026-04-07 Keith Barnatchez , Kevin P. Josey , Rachel C. Nethery , Giovanni Parmigiani

Generative AI has achieved remarkable empirical success, but from the perspective of statistics it often remains opaque: its predictions may be accurate, yet the underlying mechanism is difficult to interpret, analyze, and trust. This book…

Machine Learning · Statistics 2026-03-11 Shinto Eguchi

Accurate estimation of counterfactual outcomes in high-dimensional data is crucial for decision-making and understanding causal relationships and intervention outcomes in various domains, including healthcare, economics, and social…

Machine Learning · Computer Science 2024-07-31 Jiageng Zhu , Hanchen Xie , Jiazhi Li , Wael Abd-Almageed

Counterfactual explanations (CFs) provide human-interpretable insights into model's predictions by identifying minimal changes to input features that would alter the model's output. However, existing methods struggle to generate multiple…

Machine Learning · Computer Science 2026-02-20 Oleksii Furman , Patryk Marszałek , Jan Masłowski , Piotr Gaiński , Maciej Zięba , Marek Śmieja

Given an observational study with $n$ independent but heterogeneous units, our goal is to learn the counterfactual distribution for each unit using only one $p$-dimensional sample per unit containing covariates, interventions, and outcomes.…

Machine Learning · Computer Science 2023-09-18 Abhin Shah , Raaz Dwivedi , Devavrat Shah , Gregory W. Wornell

Estimating the counterfactual outcome of treatment is essential for decision-making in public health and clinical science, among others. Often, treatments are administered in a sequential, time-varying manner, leading to an exponentially…

Machine Learning · Statistics 2024-07-16 Shenghao Wu , Wenbin Zhou , Minshuo Chen , Shixiang Zhu

The growing integration of machine learning (ML) and artificial intelligence (AI) models into high-stakes domains such as healthcare and scientific research calls for models that are not only accurate but also interpretable. Among the…

Machine Learning · Computer Science 2025-10-23 Zhuo Cao , Xuan Zhao , Lena Krieger , Hanno Scharr , Ira Assent

Counterfactual distributions are important ingredients for policy analysis and decomposition analysis in empirical economics. In this article we develop modeling and inference tools for counterfactual distributions based on regression…

Methodology · Statistics 2017-11-23 Victor Chernozhukov , Ivan Fernandez-Val , Blaise Melly

A machine learning model, under the influence of observed or unobserved confounders in the training data, can learn spurious correlations and fail to generalize when deployed. For image classifiers, augmenting a training dataset using…

Machine Learning · Computer Science 2022-12-13 Abbavaram Gowtham Reddy , Saloni Dash , Amit Sharma , Vineeth N Balasubramanian

The fundamental problem in treatment effect estimation from observational data is confounder identification and balancing. Most of the previous methods realized confounder balancing by treating all observed pre-treatment variables as…

Methodology · Statistics 2021-10-13 Anpeng Wu , Kun Kuang , Junkun Yuan , Bo Li , Runze Wu , Qiang Zhu , Yueting Zhuang , Fei Wu

Counterfactual explanation is a form of interpretable machine learning that generates perturbations on a sample to achieve the desired outcome. The generated samples can act as instructions to guide end users on how to observe the desired…

Machine Learning · Computer Science 2023-03-28 Tri Dung Duong , Qian Li , Guandong Xu

Counterfactual analysis is intuitively performed by humans on a daily basis eg. "What should I have done differently to get the loan approved?". Such counterfactual questions also steer the formulation of scientific hypotheses. More…

Machine Learning · Computer Science 2023-09-18 Juliane Weilbach , Sebastian Gerwinn , Melih Kandemir , Martin Fraenzle

Counterfactual data augmentation has recently emerged as a method to mitigate confounding biases in the training data. These biases, such as spurious correlations, arise due to various observed and unobserved confounding variables in the…

Machine Learning · Computer Science 2023-11-22 Abbavaram Gowtham Reddy , Saketh Bachu , Saloni Dash , Charchit Sharma , Amit Sharma , Vineeth N Balasubramanian

There is a broad consensus on the importance of deep learning models in tasks involving complex data. Often, an adequate understanding of these models is required when focusing on the transparency of decisions in human-critical…

Counterfactual explanations have been a popular method of post-hoc explainability for a variety of settings in Machine Learning. Such methods focus on explaining classifiers by generating new data points that are similar to a given…

Machine Learning · Computer Science 2024-10-21 Joshua Nathaniel Williams , Anurag Katakkar , Hoda Heidari , J. Zico Kolter

Personalized decision making requires the knowledge of potential outcomes under different treatments, and confidence intervals about the potential outcomes further enrich this decision-making process and improve its reliability in…

Machine Learning · Computer Science 2024-05-22 Zonghao Chen , Ruocheng Guo , Jean-François Ton , Yang Liu

To reach human level intelligence, learning algorithms need to incorporate causal reasoning. But identifying causality, and particularly counterfactual reasoning, remains elusive. In this paper, we make progress on counterfactual inference…

Machine Learning · Statistics 2026-03-31 Marc Braun , Jose M. Peña , Adel Daoud

Counterfactual explanations have been successfully applied to create human interpretable explanations for various black-box models. They are handy for tasks in the image domain, where the quality of the explanations benefits from recent…

Machine Learning · Computer Science 2025-03-27 Trung Duc Ha , Sidney Bender
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