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Recent studies have demonstrated the feasibility of modeling single-cell data as natural languages and the potential of leveraging powerful large language models (LLMs) for understanding cell biology. However, a comprehensive evaluation of…

Quantitative Methods · Quantitative Biology 2025-05-14 Fan Zhang , Tianyu Liu , Zhihong Zhu , Hao Wu , Haixin Wang , Donghao Zhou , Yefeng Zheng , Kun Wang , Xian Wu , Pheng-Ann Heng

Structural modeling is a fundamental component of computational engineering science, in which even minor physical inconsistencies or specification violations may invalidate downstream simulations. The potential of large language models…

Software Engineering · Computer Science 2026-02-10 Yongqing Jiang , Jianze Wang , Zhiqi Shen , Zhenghong Lin , Jiayuan Wang , Yijian Yang , Kaoshan Dai , Haoran Luo

In the field of software engineering, applying language models to the token sequence of source code is the state-of-art approach to build a code recommendation system. The syntax tree of source code has hierarchical structures. Ignoring the…

Software Engineering · Computer Science 2022-11-29 Yixiao Yang

Concept bottleneck models (CBMs), which predict human-interpretable concepts (e.g., nucleus shapes in cell images) before predicting the final output (e.g., cell type), provide insights into the decision-making processes of the model.…

Computer Vision and Pattern Recognition · Computer Science 2024-07-10 Winnie Pang , Xueyi Ke , Satoshi Tsutsui , Bihan Wen

Recursive reasoning models such as Hierarchical Reasoning Model (HRM) and Tiny Recursive Model (TRM) show that small, weight-shared networks can solve compute-heavy and NP puzzles by iteratively refining latent states, but their training…

Artificial Intelligence · Computer Science 2026-03-18 Navid Hakimi

Concept Bottleneck Models (CBMs) ground image classification on human-understandable concepts to allow for interpretable model decisions. Crucially, the CBM design inherently allows for human interventions, in which expert users are given…

Machine Learning · Computer Science 2024-08-07 Nishad Singhi , Jae Myung Kim , Karsten Roth , Zeynep Akata

With the evolution of large language models (LLMs), there is growing interest in leveraging their rich semantic understanding to enhance industrial recommendation systems (RecSys). Traditional RecSys relies on ID-based embeddings for user…

Expert-level scientific reasoning remains challenging for large language models, particularly on benchmarks such as Humanity's Last Exam (HLE), where rigid tool pipelines, brittle multi-agent coordination, and inefficient test-time scaling…

Artificial Intelligence · Computer Science 2026-02-05 Zhentao Tang , Yuqi Cui , Shixiong Kai , Wenqian Zhao , Ke Ye , Xing Li , Anxin Tian , Zehua Pei , Hui-Ling Zhen , Shoubo Hu , Xiaoguang Li , Yunhe Wang , Mingxuan Yuan

Addressing the issues of hallucinations and outdated knowledge in large language models is critical for their reliable application. Model Editing presents a promising avenue for mitigating these challenges in a cost-effective manner.…

Computation and Language · Computer Science 2024-08-09 Zihan Yao , Yu He , Tianyu Qi , Ming Li

We propose RocketScience, an open-source contrastive VLM benchmark that tests for spatial relation understanding. It is comprised of entirely new real-world image-text pairs covering mostly relative spatial understanding and the order of…

Computer Vision and Pattern Recognition · Computer Science 2025-09-05 Nils Hoehing , Mayug Maniparambil , Ellen Rushe , Noel E. O'Connor , Anthony Ventresque

Scientific applications often contain large, computationally-intensive, and irregular parallel loops or tasks that exhibit stochastic characteristics. Applications may suffer from load imbalance during their execution on high-performance…

Distributed, Parallel, and Cluster Computing · Computer Science 2019-10-16 Ali Mohammed , Ahmed Eleliemy , Florina M. Ciorba , Franziska Kasielke , Ioana Banicescu

Recent advancements highlight the success of instruction tuning with large language models (LLMs) utilizing Chain-of-Thought (CoT) data for mathematical reasoning tasks. Despite the fine-tuned LLMs, challenges persist, such as incorrect,…

Computation and Language · Computer Science 2024-03-28 Yongwei Zhou , Tiejun Zhao

Large Language Models (LLMs) exhibit impressive reasoning abilities, yet their reliance on structured step-by-step processing reveals a critical limitation. In contrast, human cognition fluidly adapts between intuitive, heuristic (System 1)…

Computation and Language · Computer Science 2025-10-16 Alireza S. Ziabari , Nona Ghazizadeh , Zhivar Sourati , Farzan Karimi-Malekabadi , Payam Piray , Morteza Dehghani

The global shortage of healthcare workers has demanded the development of smart healthcare assistants, which can help monitor and alert healthcare workers when necessary. We examine the healthcare knowledge of existing Large Vision Language…

Computation and Language · Computer Science 2024-10-10 Sourjyadip Ray , Kushal Gupta , Soumi Kundu , Payal Arvind Kasat , Somak Aditya , Pawan Goyal

Deep, overparameterized regression models are notorious for their tendency to overfit. This problem is exacerbated in heteroskedastic models, which predict both mean and residual noise for each data point. At one extreme, these models fit…

Machine Learning · Statistics 2024-02-15 Eliot Wong-Toi , Alex Boyd , Vincent Fortuin , Stephan Mandt

Generative sequence modeling faces a fundamental tension between the expressivity of Transformers and the efficiency of linear sequence models. Existing efficient architectures are theoretically bounded by shallow, single-step linear…

Machine Learning · Computer Science 2026-02-13 Jie Jiang , Ke Cheng , Xin Xu , Mengyang Pang , Tianhao Lu , Jiaheng Li , Yue Liu , Yuan Wang , Jun Zhang , Huan Yu , Zhouchen Lin

Humans can robustly localize visual evidence and provide grounded answers even in noisy environments by identifying critical cues and then relating them to the full context in a bottom-up manner. Inspired by this, we propose DeepScan, a…

Computer Vision and Pattern Recognition · Computer Science 2026-03-05 Yangfu Li , Hongjian Zhan , Jiawei Chen , Yuning Gong , Qi Liu , Yue Lu

Large language models (LLMs) have achieved strong performance across a wide range of natural language processing tasks. However, deploying LLMs at scale for domain specific applications, such as job-person fit and explanation in job seeking…

Building virtual cells with generative models to simulate cellular behavior in silico is emerging as a promising paradigm for accelerating drug discovery. However, prior image-based generative approaches can produce implausible cell images…

Machine Learning · Computer Science 2026-05-22 Dongxia Wu , Shiye Su , Yuhui Zhang , Elaine Sui , Emma Lundberg , Emily B. Fox , Serena Yeung-Levy

Multi-agent collaboration among models has shown promise in reasoning tasks but is underexplored in long-form generation tasks like summarization and question-answering. We extend multi-agent multi-model reasoning to generation,…

Computation and Language · Computer Science 2025-03-20 David Wan , Justin Chih-Yao Chen , Elias Stengel-Eskin , Mohit Bansal