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Identification of human genes involved in the aging process is critical due to the incidence of many diseases with age. A state-of-the-art approach for this purpose infers a weighted dynamic aging-specific subnetwork by mapping gene…

Molecular Networks · Quantitative Biology 2022-05-27 Qi Li , Khalique Newaz , Tijana Milenković

Gait analysis holds significant importance in monitoring daily health, particularly among older adults. Advancements in sensor technology enable the capture of movement in real-life environments and generate big data. Machine learning,…

Machine Learning · Computer Science 2024-11-18 Xiaoping Zheng , Bert Otten , Michiel F Reneman , Claudine JC Lamoth

Despite the thousands of genes implicated in age-related phenotypes, effective interventions for aging remain elusive, a lack of advance rooted in the multifactorial nature of longevity and the functional interconnectedness of the molecular…

Molecular Networks · Quantitative Biology 2025-09-04 Bnaya Gross , Joseph Ehlert , Vadim N. Gladyshev , Joseph Loscalzo , Albert-László Barabási

Routinely collected clinical blood tests are an emerging molecular data source for large-scale biomedical research but inherently feature irregular sampling and informative observation. Traditional approaches rely on imputation, which can…

Quantitative Methods · Quantitative Biology 2025-03-20 Andrea Zerio , Maya Bechler-Speicher , Tine Jess , Aleksejs Sazonovs

We present a novel graph neural network (GNN) architecture for retrieval-augmented generation (RAG) that leverages query-aware attention mechanisms and learned scoring heads to improve retrieval accuracy on complex, multi-hop questions.…

Information Retrieval · Computer Science 2025-08-11 Vibhor Agrawal , Fay Wang , Rishi Puri

Over the past few years, graph representation learning (GRL) has been a powerful strategy for analyzing graph-structured data. Recently, GRL methods have shown promising results by adopting self-supervised learning methods developed for…

Machine Learning · Computer Science 2022-09-05 Namkyeong Lee , Dongmin Hyun , Junseok Lee , Chanyoung Park

Gene Regulatory Network (GRN) plays an important role in knowing insight of cellular life cycle. It gives information about at which different environmental conditions genes of particular interest get over expressed or under expressed.…

Computational Engineering, Finance, and Science · Computer Science 2013-10-10 Chanda Panse , Dr. Manali Kshirsagar

Background:Gene regulations often change over time rather than being constant. But many of gene regulatory networks extracted from databases are static. The tumor suppressor gene $P53$ is involved in the pathogenesis of many tumors, and its…

Molecular Networks · Quantitative Biology 2021-11-02 Ruijie Xu , Lin Zhang , Yu Chen

Background: While deep learning technology, which has the capability of obtaining latent representations based on large-scale data, can be a potential solution for the discovery of a novel aging biomarker, existing deep learning methods for…

Machine Learning · Computer Science 2023-02-02 Seong-Eun Moon , Ji Won Yoon , Shinyoung Joo , Yoohyung Kim , Jae Hyun Bae , Seokho Yoon , Haanju Yoo , Young Min Cho

Dynamic Graph Neural Networks (DGNNs) have emerged as the predominant approach for processing dynamic graph-structured data. However, the influence of temporal information on model performance and robustness remains insufficiently explored,…

Machine Learning · Computer Science 2023-11-27 Xiangjian Jiang , Yanyi Pu

Biological age, which may be older or younger than chronological age due to factors such as genetic predisposition, environmental exposures, serves as a meaningful biomarker of aging processes and can inform risk stratification, treatment…

Genomics · Quantitative Biology 2025-11-11 Shuyue Jiang , Wenjing Ma , Shaojun Yu , Chang Su , Runze Yan , Jiaying Lu

This paper introduces a novel Graph Neural Network (GNN) architecture for time series classification, based on visibility graph representations. Traditional time series classification methods often struggle with high computational…

Machine Learning · Computer Science 2024-10-15 Paulo Coelho , Raul Araju , Luís Ramos , Samir Saliba , Renato Vimieiro

Graph Neural Networks (GNNs), a generalization of deep neural networks on graph data have been widely used in various domains, ranging from drug discovery to recommender systems. However, GNNs on such applications are limited when there are…

Machine Learning · Computer Science 2021-11-09 Debmalya Mandal , Sourav Medya , Brian Uzzi , Charu Aggarwal

This paper investigates body bones from skeleton data for skeleton based action recognition. Body joints, as the direct result of mature pose estimation technologies, are always the key concerns of traditional action recognition methods.…

Computer Vision and Pattern Recognition · Computer Science 2018-06-01 Xikun Zhang , Chang Xu , Xinmei Tian , Dacheng Tao

Predicting gene functions is a challenge for biologists in the post genomic era. Interactions among genes and their products compose networks that can be used to infer gene functions. Most previous studies adopt a linkage assumption, i.e.,…

Molecular Networks · Quantitative Biology 2022-04-25 Xin Li , Hsinchun Chen , Jiexun Li , Zhu Zhang

Clinical risk prediction using electronic health records (EHRs) is vital to facilitate timely interventions and clinical decision support. However, modeling heterogeneous and irregular temporal EHR data presents significant challenges. We…

Machine Learning · Computer Science 2025-11-04 Kun-Wei Lin , Yu-Chen Kuo , Hsin-Yao Wang , Yi-Ju Tseng

Age progression is defined as aesthetically re-rendering the aging face at any future age for an individual face. In this work, we aim to automatically render aging faces in a personalized way. Basically, for each age group, we learn an…

Computer Vision and Pattern Recognition · Computer Science 2017-06-06 Xiangbo Shu , Jinhui Tang , Zechao Li , Hanjiang Lai , Liyan Zhang , Shuicheng Yan

In the context of machine learning for graphs, many researchers have empirically observed that Deep Graph Networks (DGNs) perform favourably on node classification tasks when the graph structure is homophilic (\ie adjacent nodes are…

Machine Learning · Computer Science 2024-05-03 Daniele Castellana

In recent years, Dynamic Graph (DG) representations have been increasingly used for modeling dynamic systems due to their ability to integrate both topological and temporal information in a compact representation. Dynamic graphs allow to…

Machine Learning · Computer Science 2023-04-13 Leshanshui Yang , Sébastien Adam , Clément Chatelain

Real data collected from different applications that have additional topological structures and connection information are amenable to be represented as a weighted graph. Considering the node labeling problem, Graph Neural Networks (GNNs)…

Social and Information Networks · Computer Science 2020-02-06 Xiaoxiao Li , Joao Saude
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