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We present a combined numerical and data-driven workflow for efficient prediction of nonlinear, instationary convection-diffusion-reaction dynamics on a two-dimensional phenotypic domain, motivated by macroscopic modeling of cancer cell…

Computational Engineering, Finance, and Science · Computer Science 2026-02-02 Michael Urs Lars Kastor , Jan Rottmayer , Anna Hundertmark , Nicolas Ralph Gauger

Continued progress in inertial confinement fusion (ICF) requires solving inverse problems relating experimental observations to simulation input parameters, followed by design optimization. However, such high-dimensional dynamic…

Computational Physics · Physics 2026-01-06 Tyler E. Maltba , Ben S. Southworth , Jeffrey R. Haack , Marc L. Klasky

We present a hybrid sampling-surrogate approach for reducing the computational expense of uncertainty quantification in nonlinear dynamical systems. Our motivation is to enable rapid uncertainty quantification in complex mechanical systems…

Computation · Statistics 2022-01-27 Hang Yang , Yuji Fujii , K. W. Wang , Alex A. Gorodetsky

Existing model validation studies in geoscience often disregard or partly account for uncertainties in observations, model choices, and input parameters. In this work, we develop a statistical framework that incorporates a probabilistic…

The plasma edge flow, situated at the intricate boundary between plasma and neutral particles, plays a pivotal role in the design of nuclear fusion devices such as divertors and pumps. Traditional numerical simulation methods, such as the…

Computational Physics · Physics 2024-11-14 Yifan Wen , Yanbing Zhang , Lei Wu

Simulations play a key role for inference in collider physics. We explore various approaches for enhancing the precision of simulations using machine learning, including interventions at the end of the simulation chain (reweighting), at the…

High Energy Physics - Phenomenology · Physics 2023-10-24 Benjamin Nachman , Ramon Winterhalder

This study introduces a surrogate modeling framework merging proper orthogonal decomposition, long short-term memory networks, and multi-task learning, to accurately predict elastoplastic deformations in real-time. Superior to single-task…

Computational Engineering, Finance, and Science · Computer Science 2024-11-11 Ruben Schmeitz , Joris Remmers , Olga Mula , Olaf van der Sluis

The rapid growth of large-scale machine learning (ML) models has led numerous commercial companies to utilize ML models for generating predictive results to help business decision-making. As two primary components in traditional predictive…

Performance · Computer Science 2024-01-25 Wenbo Sun , Asterios Katsifodimos , Rihan Hai

Optimal transport has recently been brought forward as a tool for modeling and efficiently solving a variety of flow problems, such as origin-destination problems and multi-commodity flow problems. Although the framework has shown to be…

Optimization and Control · Mathematics 2025-07-29 Anqi Dong , Karl Henrik Johansson , Johan Karlsson

A surrogate-based topology optimisation algorithm for linear elastic structures under parametric loads and boundary conditions is proposed. Instead of learning the parametric solution of the state (and adjoint) problems or the optimisation…

Numerical Analysis · Mathematics 2025-11-04 Matteo Giacomini , Antonio Huerta

Biophysical neural system simulations are among the most computationally demanding scientific applications, and their optimization requires navigating high-dimensional parameter spaces under numerous constraints that impose a binary…

Turbulent transport is regarded as one of the key issues in magnetic confinement nuclear fusion, both for tokamaks in stellarators. In this work, we show that a significant decrease in a microstability-based proxy, as opposed to a geometric…

Plasma Physics · Physics 2024-08-30 R. Jorge , W. Dorland , P. Kim , M. Landreman , N. R. Mandell , G. Merlo , T. Qian

Production optimization in stress-sensitive unconventional reservoirs is governed by a nonlinear trade-off between pressure-driven flow and stress-induced degradation of fracture conductivity and matrix permeability. While higher drawdown…

Machine Learning · Computer Science 2026-04-02 Mahammad Valiyev , Jodel Cornelio , Behnam Jafarpour

Diffusion model deployment has been suffering from high energy consumption and inference latency despite its superior performance in visual generation tasks. Dynamic voltage and frequency scaling (DVFS) offers a promising solution to…

Hardware Architecture · Computer Science 2026-04-13 Jinqi Wen , Tong Xie , Runsheng Wang , Meng Li

When designing new materials, it is often necessary to design a material with specific desired properties. Unfortunately, as new design variables are added, the search space grows exponentially, which makes synthesizing and validating the…

Machine Learning · Computer Science 2025-10-10 Shaan Pakala , Aldair E. Gongora , Brian Giera , Evangelos E. Papalexakis

Increasing urban concentration raises operational challenges that can benefit from integrated monitoring and decision support. Such complex systems need to leverage the full stack of analytical methods, from state estimation using…

Computers and Society · Computer Science 2024-09-23 Sebastien Blandin , Laura Wynter , Hasan Poonawala , Sean Laguna , Basile Dura

Deep learning surrogate modeling shows great promise for subsurface flow applications, but the training demands can be substantial. Here we introduce a new surrogate modeling framework to predict CO2 saturation, pressure and surface…

Machine Learning · Computer Science 2024-08-21 Yifu Han , Francois P. Hamon , Louis J. Durlofsky

Optimization and uncertainty quantification have been playing an increasingly important role in computational hemodynamics. However, existing methods based on principled modeling and classic numerical techniques have faced significant…

Medical Physics · Physics 2022-09-07 Pan Du , Xiaozhi Zhu , Jian-Xun Wang

Reynolds-averaged Navier-Stokes (RANS) equations are widely used in engineering turbulent flow simulations. However, RANS predictions may have large discrepancies due to the uncertainties in modeled Reynolds stresses. Recently, Wang et al.…

Fluid Dynamics · Physics 2018-09-11 Jin-Long Wu , Heng Xiao , Eric Paterson

This study presents a transit routing, assignment, and simulation framework which is fully embedded in a multimodal, multi-agent transportation demand and supply modeling platform. POLARIS, a high-performance agent-based simulation…

Systems and Control · Electrical Eng. & Systems 2024-08-12 Omer Verbas , Taner Cokyasar , Pedro Veiga de Camargo , Krishna Murthy Gurumurthy , Natalia Zuniga-Garcia , Joshua Auld