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Related papers: ProtSent: Protein Sentence Transformers

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Pretrained language models (PLMs) display impressive performances and have captured the attention of the NLP community. Establishing best practices in pretraining has, therefore, become a major focus of NLP research, especially since…

Computation and Language · Computer Science 2024-10-08 Zihao Li , Shaoxiong Ji , Timothee Mickus , Vincent Segonne , Jörg Tiedemann

Understanding protein solubility is essential for their functional applications. Computational methods for predicting protein solubility are crucial for reducing experimental costs and enhancing the efficiency and success rates of protein…

Quantitative Methods · Quantitative Biology 2024-07-01 Yang Tan , Jia Zheng , Liang Hong , Bingxin Zhou

Protein language models are trained primarily with masked language modeling (MLM), which predicts amino-acid identities at masked positions. We ask whether latent-space prediction can complement these token-level objectives under matched…

Machine Learning · Computer Science 2026-05-11 Dan Ofer , Dafna Shahaf , Michal Linial

Most existing pre-trained language representation models (PLMs) are sub-optimal in sentiment analysis tasks, as they capture the sentiment information from word-level while under-considering sentence-level information. In this paper, we…

Computation and Language · Computer Science 2022-10-20 Shuai Fan , Chen Lin , Haonan Li , Zhenghao Lin , Jinsong Su , Hang Zhang , Yeyun Gong , Jian Guo , Nan Duan

Protein is linked to almost every life process. Therefore, analyzing the biological structure and property of protein sequences is critical to the exploration of life, as well as disease detection and drug discovery. Traditional protein…

Machine Learning · Computer Science 2021-12-08 Yijia Xiao , Jiezhong Qiu , Ziang Li , Chang-Yu Hsieh , Jie Tang

Large language models (LLMs) that fluently converse with humans are a reality - but do LLMs experience human-like processing difficulties? We systematically compare human and LLM sentence comprehension across seven challenging linguistic…

Computation and Language · Computer Science 2025-10-17 Samuel Joseph Amouyal , Aya Meltzer-Asscher , Jonathan Berant

Recently, prompt tuning (PT) has gained increasing attention as a parameter-efficient way of tuning pre-trained language models (PLMs). Despite extensively reducing the number of tunable parameters and achieving satisfying performance, PT…

Computation and Language · Computer Science 2022-11-15 Yufei Huang , Yujia Qin , Huadong Wang , Yichun Yin , Maosong Sun , Zhiyuan Liu , Qun Liu

Proteins inherently possess a consistent sequence-structure duality. The abundance of protein sequence data, which can be readily represented as discrete tokens, has driven fruitful developments in protein language models (pLMs). A key…

Computational Engineering, Finance, and Science · Computer Science 2026-05-29 Yi Zhou , Haohao Qu , Yunqing Liu , Shanru Lin , Le Song , Wenqi Fan

The emergence of pre-trained language models (PLMs) has shown great success in many Natural Language Processing (NLP) tasks including text classification. Due to the minimal to no feature engineering required when using these models, PLMs…

Computation and Language · Computer Science 2022-11-07 Yasmen Wahba , Nazim Madhavji , John Steinbacher

Reranking is fundamental to information retrieval and retrieval-augmented generation, with recent Large Language Models (LLMs) significantly advancing reranking quality. Most current works rely on large-scale LLMs (>7B parameters),…

Information Retrieval · Computer Science 2026-04-17 Xianming Li , Aamir Shakir , Rui Huang , Tsz-fung Andrew Lee , Julius Lipp , Benjamin Clavié , Jing Li

Emotion recognition from speech is a challenging task that requires capturing both linguistic and paralinguistic cues, with critical applications in human-computer interaction and mental health monitoring. Recent works have highlighted the…

Audio and Speech Processing · Electrical Eng. & Systems 2025-08-21 Hugo Thimonier , Antony Perzo , Renaud Seguier

Large language models (LLMs) have expanded from text to speech, giving rise to Speech Large Models (SLMs) that support recognition, translation, and synthesis. A key challenge is aligning speech and text representations, which becomes…

Computation and Language · Computer Science 2025-09-25 Pei Zhang , Andong Chen , Xi Chen , Baosong Yang , Derek F. Wong , Fei Huang

Self-supervised neural language models with attention have recently been applied to biological sequence data, advancing structure, function and mutational effect prediction. Some protein language models, including MSA Transformer and…

Biomolecules · Quantitative Biology 2022-10-25 Umberto Lupo , Damiano Sgarbossa , Anne-Florence Bitbol

Self-supervised training of language models (LMs) has seen great success for protein sequences in learning meaningful representations and for generative drug design. Most protein LMs are based on the Transformer architecture trained on…

Biomolecules · Quantitative Biology 2025-04-03 Yingheng Wang , Zichen Wang , Gil Sadeh , Luca Zancato , Alessandro Achille , George Karypis , Huzefa Rangwala

Pre-trained Transformer language models (LM) have become go-to text representation encoders. Prior research fine-tunes deep LMs to encode text sequences such as sentences and passages into single dense vector representations for efficient…

Computation and Language · Computer Science 2021-09-22 Luyu Gao , Jamie Callan

Recent advances in generative modeling show that pretrained representations can improve generation as conditioning features or alignment targets. Motivated by this, we study protein representations for predicting structures beyond…

Biomolecules · Quantitative Biology 2026-05-27 Taewon Kim , Hyosoon Jang , Hyunjin Seo , Seonghwan Seo , Hyeongwoo Kim , Wonho Zhung , Mingyeong Shin , Wooyoun Kim , Sungsoo Ahn

Protein-protein interactions (PPIs) are fundamental to numerous cellular processes, and their characterization is vital for understanding disease mechanisms and guiding drug discovery. While protein language models (PLMs) have demonstrated…

Sentence embeddings are crucial in measuring semantic similarity. Most recent studies employed large language models (LLMs) to learn sentence embeddings. Existing LLMs mainly adopted autoregressive architecture without explicit backward…

Computation and Language · Computer Science 2024-03-15 Xianming Li , Jing Li

Pre-trained language models (PLMs) like BERT are being used for almost all language-related tasks, but interpreting their behavior still remains a significant challenge and many important questions remain largely unanswered. In this work,…

Computation and Language · Computer Science 2021-09-28 Samuel Stevens , Yu Su

Recent research demonstrates the effectiveness of using pretrained language models (PLM) to improve dense retrieval and multilingual dense retrieval. In this work, we present a simple but effective monolingual pretraining task called…

Information Retrieval · Computer Science 2022-06-08 Ning Wu , Yaobo Liang , Houxing Ren , Linjun Shou , Nan Duan , Ming Gong , Daxin Jiang