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Third harmonic generation (THG) provides a valuable, label-free approach to imaging biological systems. To date, THG microscopy has been performed using point scanning methods that rely on intensity measurements lacking phase information of…

This work introduces a novel reinterpretation of structured illumination (SI) microscopy for coherent imaging that allows three-dimensional imaging of complex refractive index (RI). To do so, we show that coherent SI is mathematically…

Optics · Physics 2017-05-11 Shwetadwip Chowdhury , Will J. Eldridge , Adam Wax , Joseph A. Izatt

Structured light illumination is an active 3-D scanning technique based on projecting/capturing a set of striped patterns and measuring the warping of the patterns as they reflect off a target object's surface. In the case of phase…

Computer Vision and Pattern Recognition · Computer Science 2017-06-09 Daniel L. Lau , Yu Zhang , Kai Liu

Optical coherence tomography (OCT) is a micrometer-scale, volumetric imaging modality that has become a clinical standard in ophthalmology. OCT instruments image by raster-scanning a focused light spot across the retina, acquiring…

Image and Video Processing · Electrical Eng. & Systems 2022-09-16 Stefan Ploner , Siyu Chen , Jungeun Won , Lennart Husvogt , Katharina Breininger , Julia Schottenhamml , James Fujimoto , Andreas Maier

Since specular reflection often exists in the real captured images and causes deviation between the recorded color and intrinsic color, specular reflection separation can bring advantages to multiple applications that require consistent…

Computer Vision and Pattern Recognition · Computer Science 2022-01-26 Sijia Wen , Yingqiang Zheng , Feng Lu

This article presents a method to perform diffraction tomography in a standard microscope that includes an LED array for illumination. After acquiring a sequence of intensity-only images of a thick sample, a ptychography-based…

Optics · Physics 2015-10-30 Roarke Horstmeyer , Changhuei Yang

Spectral Photon-Counting Computed Tomography (SPCCT) is a promising technology that has shown a number of advantages over conventional X-ray Computed Tomography (CT) in the form of material separation, artefact removal and enhanced image…

Image and Video Processing · Electrical Eng. & Systems 2020-03-10 Dimitris Kamilis , Mario Blatter , Nick Polydorides

We demonstrate a preliminary setup of a combined MHz-OCT and RGB narrowband reflection microscope and investigate the performance of the new RGB branch and different display modes of colored OCT data sets.

Medical Physics · Physics 2020-08-13 Madita Goeb , Tom Pfeiffer , Robert Huber

Photon correlation spectroscopy (PCS) is based on measuring the temporal correlation of the light intensity scattered by the investigated sample. A typical setup requires a temporally coherent light source. Here, we show that a…

Optics · Physics 2015-05-30 D. Salerno , D. Brogioli , F. Croccolo , R. Ziano , F. Mantegazza

Optical coherence tomography (OCT) captures cross-sectional data and is used for the screening, monitoring, and treatment planning of retinal diseases. Technological developments to increase the speed of acquisition often results in systems…

Image and Video Processing · Electrical Eng. & Systems 2023-01-03 Timothy T. Yu , Da Ma , Jayden Cole , Myeong Jin Ju , Mirza F. Beg , Marinko V. Sarunic

With the growing technology of photon-counting detectors (PCD), spectral CT is a widely concerned topic which has the potential of material differentiation. However, due to some non-ideal factors such as cross talk and pulse pile-up of the…

Medical Physics · Physics 2020-07-21 Ao Zheng , Hongkai Yang , Li Zhang , Yuxiang Xing

We report on a theoretical model for image formation in full-field optical coherence tomography (FFOCT). Because the spatial incoherence of the illumination acts as a virtual confocal pinhole in FFOCT, its imaging performance is equivalent…

Coherent Diffractive Imaging is a lensless technique that allows imaging of matter at a spatial resolution not limited by lens aberrations. This technique exploits the measured diffraction pattern of a coherent beam scattered by periodic…

Computational Physics · Physics 2025-08-27 Alessandro Colombo , Davide Emilio Galli , Liberato De Caro , Francesco Scattarella , Elvio Carlino

Dynamic optical coherence tomography (DOCT) statistically analyzes fluctuations in time-sequential OCT signals, enabling label-free and three-dimensional visualization of intratissue and intracellular activities. Current DOCT methods, such…

We present a stochastic analog spatial light modulator designed for compressive imaging applications. We rely on the unpredictable nature of multi-particle collisions to provide randomization for the particle location. We demonstrate this…

Image and Video Processing · Electrical Eng. & Systems 2018-10-23 J. C. Schaake , R. C. Pooser , S. Jesse

While micro-CT systems are instrumental in preclinical research, clinical micro-CT imaging has long been desired with cochlear implantation as a primary example. The structural details of the cochlear implant and the temporal bone require a…

We show a monotonic relationship between performances of various computer vision tasks versus degrees of coherence of illumination. We simulate partially coherent illumination using computational methods, propagate the lightwave to form…

Computer Vision and Pattern Recognition · Computer Science 2024-01-08 Zichen Xie , Ken Xingze Wang

Single-shot diffraction imaging of isolated nanosized particles has seen remarkable success in recent years, yielding in-situ measurements with ultra-high spatial and temporal resolution. The progress of high-repetition-rate sources for…

Atomic and Molecular Clusters · Physics 2022-08-26 Julian Zimmermann , Fabien Beguet , Daniel Guthruf , Bruno Langbehn , Daniela Rupp

Optical-resolution fluorescence imaging through and within complex samples presents a significant challenge due to random light scattering, with substantial implications across multiple fields. While significant advancements in coherent…

Optics · Physics 2023-12-27 Gil Weinberg , Elad Sunray , Ori Katz

Simultaneous imaging of fluorescence-labeled and label-free phase objects in the same sample provides distinct and complementary information. Most multimodal fluorescence-phase imaging operates in transmission mode, capturing fluorescence…

Optics · Physics 2024-08-20 Renzhi He , Yucheng Li , Junjie Chen , Yi Xue
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