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Density Functional Theory (DFT) stands as a widely used and efficient approach for addressing the many-electron Schr\"odinger equation across various domains such as physics, chemistry, and biology. However, a core challenge that persists…

Computational Engineering, Finance, and Science · Computer Science 2024-12-25 Sizhuo Jin , Shuo Chen , Jianjun Qian , Ying Tai , Jun Li

Using an end-to-end differentiable implementation of the Kohn-Sham self-consistent field equations, we obtain an accurate neural network-based exchange and correlation (XC) functional of the electronic density. The functional is optimized…

Chemical Physics · Physics 2021-06-09 Sebastian Dick , Marivi Fernandez-Serra

Density Functional Theory (DFT) underpins much of modern computational chemistry and materials science. Yet, the reliability of DFT-derived predictions of experimentally measurable properties remains fundamentally limited by the need to…

Accelerated discovery with machine learning (ML) has begun to provide the advances in efficiency needed to overcome the combinatorial challenge of computational materials design. Nevertheless, ML-accelerated discovery both inherits the…

Materials Science · Physics 2022-05-09 Chenru Duan , Fang Liu , Aditya Nandy , Heather J. Kulik

Kohn-Sham density functional theory (DFT) is the workhorse of quantum chemistry, offering an attractive balance between accuracy and computational cost. Although exact in principle, DFT in practice relies on an approximation to the unknown…

Quantum Physics · Physics 2026-05-12 Karim K. Alaa El-Din , Antonius v. Strachwitz , Sam M. Vinko

Multiconfiguration pair-density functional theory (MC-PDFT) offers an efficient and accurate framework for computing electronic energies in strongly correlated molecular systems, with the quality of the on-top functional being a key…

Chemical Physics · Physics 2026-05-08 Yuhao Chen , Donald G. Truhlar , Xiao He

Density functional theory (DFT) is one of the primary approaches to get a solution to the many-body Schrodinger equation. The essential part of the DFT theory is the exchange-correlation (XC) functional, which can not be obtained in…

Computational Physics · Physics 2021-12-10 Alexander Ryabov , Petr Zhilyaev

Agentic discovery has shown that LLM-driven search can find novel algorithms, designs, and code under benchmark conditions. Translating the paradigm to multi-system data backends surfaces a harder problem: the search space is heterogeneous,…

Artificial Intelligence · Computer Science 2026-05-27 Shanshan Ye , Duo Lu

A hybrid Kohn-Sham Density Functional Theory (KS-DFT) and 1-electron Reduced Density Matrix Functional Theory (1-RDMFT) has recently been developed to describe strongly correlated systems at mean-field computational cost. This approach…

Computational Physics · Physics 2025-04-14 Daniel Gibney , Jan-Niklas Boyn

Standard density functional theory (DFT) routinely misclassifies the electronic ground state of correlated and structurally complex compounds, predicting metallic behaviour for materials that experiments report as semiconductors. Each such…

Materials Science · Physics 2026-04-30 Yue Li , Bijun Tang

Density functional theory (DFT) serves as the basis for computational discovery in materials science and chemistry, yet each calculation demands extensive human effort: adjusting algorithms when convergence stalls, revising plans when…

Materials Science · Physics 2026-05-27 Penghui Yang , Zhonghan Zhang , Yue Li , Xinrun Wag , Yanchen Deng , Yuhao Lu , Bijun Tang , Zheng Liu , Bo An

Machine learning (ML) has recently gained attention as a means to develop more accurate exchange-correlation (XC) functionals for density functional theory, but functionals developed thus far need to be improved on several metrics,…

Chemical Physics · Physics 2022-03-14 Kyle Bystrom , Boris Kozinsky

Materials discovery relies on high-throughput, high-fidelity simulation techniques such as Density Functional Theory (DFT), which require years of training, extensive parameter fine-tuning and systematic error handling. To address these…

Artificial Intelligence · Computer Science 2025-07-22 Ziqi Wang , Hongshuo Huang , Hancheng Zhao , Changwen Xu , Shang Zhu , Jan Janssen , Venkatasubramanian Viswanathan

Advancements in Large Language Models (LLMs) are revolutionizing the development of autonomous agentic systems by enabling dynamic, context-aware task decomposition and automated tool selection. These sophisticated systems possess…

Artificial Intelligence · Computer Science 2024-10-31 Adrian Garret Gabriel , Alaa Alameer Ahmad , Shankar Kumar Jeyakumar

Finding accurate exchange-correlation (XC) functionals remains the defining challenge in density functional theory (DFT). Despite 40 years of active development, the desired chemical accuracy is still elusive with existing functionals. We…

Chemical Physics · Physics 2024-09-11 Bikash Kanungo , Jeffrey Hatch , Paul M. Zimmerman , Vikram Gavini

Systematic development of accurate density functionals has been a decades-long challenge for scientists. Despite the emerging application of machine learning (ML) in approximating functionals, the resulting ML functionals usually contain…

Neural and Evolutionary Computing · Computer Science 2022-09-20 He Ma , Arunachalam Narayanaswamy , Patrick Riley , Li Li

Density functional theory (DFT) is one of the most widely used tools to solve the many-body Schrodinger equation. The core uncertainty inside DFT theory is the exchange-correlation (XC) functional, the exact form of which is still unknown.…

Computational Physics · Physics 2019-10-15 Alexander Ryabov , Iskander Akhatov , Petr Zhilyaev

Large Language Model (LLM)-based search agents have shown remarkable capabilities in solving complex tasks by dynamically decomposing problems and addressing them through interleaved reasoning and retrieval. However, this interleaved…

Artificial Intelligence · Computer Science 2025-05-20 Tiannuo Yang , Zebin Yao , Bowen Jin , Lixiao Cui , Yusen Li , Gang Wang , Xiaoguang Liu

Density Functional Theory (DFT) is used extensively in the computation of electronic properties of matter, with various applications. Approximating the exchange-correlation (XC) functional is the key to the Kohn-Sham DFT approach, the basis…

Materials Science · Physics 2025-03-17 Sameerah Helal , Zhe Tao , Cindy Rubio-González , Francois Gygi , Aditya V. Thakur

Progress in scientific discovery is rarely the result of a single "Eureka" moment, but is rather the product of hundreds of scientists incrementally working together toward a common goal. While existing agent workflows are capable of…

Artificial Intelligence · Computer Science 2025-03-25 Samuel Schmidgall , Michael Moor
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