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The aim of clinical effectiveness research using repositories of electronic health records is to identify what health interventions 'work best' in real-world settings. Since there are several reasons why the net benefit of intervention may…

Methodology · Statistics 2020-06-19 Jie Zhu , Blanca Gallego

Problem lists are intended to provide clinicians with a relevant summary of patient medical issues and are embedded in many electronic health record systems. Despite their importance, problem lists are often cluttered with resolved or…

Information Retrieval · Computer Science 2020-08-05 Justin Lovelace , Nathan C. Hurley , Adrian D. Haimovich , Bobak J. Mortazavi

Observational studies of treatment effects require adjustment for confounding variables. However, causal inference methods typically cannot deliver perfect adjustment on all measured baseline variables, and there is often ambiguity about…

Methodology · Statistics 2024-02-16 Lauren D. Liao , Yeyi Zhu , Amanda L. Ngo , Rana F. Chehab , Samuel D. Pimentel

Multi-modality cardiac imaging plays a key role in the management of patients with cardiovascular diseases. It allows a combination of complementary anatomical, morphological and functional information, increases diagnosis accuracy, and…

Image and Video Processing · Electrical Eng. & Systems 2022-08-30 Lei Li , Wangbin Ding , Liqun Huang , Xiahai Zhuang , Vicente Grau

As digital communication grows in importance when connecting with healthcare providers, traditional behavioral and content message features are imbued with renewed significance. If one is to meaningfully connect with them, it is crucial to…

There are a number of available methods for selecting whom to prioritize for treatment, including ones based on treatment effect estimation, risk scoring, and hand-crafted rules. We propose rank-weighted average treatment effect (RATE)…

Methodology · Statistics 2023-11-30 Steve Yadlowsky , Scott Fleming , Nigam Shah , Emma Brunskill , Stefan Wager

Physicians considering clinical trials for their patients are met with the laborious process of checking many text based eligibility criteria. Large Language Models (LLMs) have shown to perform well for clinical information extraction and…

Machine Learning · Computer Science 2023-06-30 Danny M. den Hamer , Perry Schoor , Tobias B. Polak , Daniel Kapitan

The development of high-throughput sequencing and targeted therapies has led to the emergence of personalized medicine: a patient's molecular profile or the presence of a specific biomarker of drug response will correspond to a treatment…

Applications · Statistics 2020-05-27 Jonas Béal , Aurélien Latouche

In domains where transparency and trustworthiness are crucial, such as healthcare, rule-based systems are widely used and often preferred over black-box models for decision support systems due to their inherent interpretability. However, as…

Machine Learning · Computer Science 2025-06-18 Christel Sirocchi , Damiano Verda

Problem Definition. Increasing costs of healthcare highlight the importance of effective disease prevention. However, decision models for allocating preventive care are lacking. Methodology/Results. In this paper, we develop a data-driven…

Machine Learning · Computer Science 2023-08-15 Mathias Kraus , Stefan Feuerriegel , Maytal Saar-Tsechansky

Globally, the incidence of heart failure is increasing, and its principal treatment involves drug therapy. However, widespread non-adherence to therapies is prevalent among heart failure patients and often results in worsening health…

Applications · Statistics 2023-12-29 Nicole Fontana , Laura Savaré , Francesca Ieva

Lyme disease is a rapidly growing illness that remains poorly understood within the medical community. Critical questions about when and why patients respond to treatment or stay ill, what kinds of treatments are effective, and even how to…

Computers and Society · Computer Science 2020-09-22 Joshua Vendrow , Jamie Haddock , Deanna Needell , Lorraine Johnson

Diabetes is a chronic disease characterised by a high risk of developing diabetic nephropathy, which, in turn, is the leading cause of end-stage chronic kidney disease. The early identification of individuals at heightened risk of such…

Quantitative Methods · Quantitative Biology 2024-09-24 Davide Dei Cas , Barbara Di Camillo , Gian Paolo Fadini , Giovanni Sparacino , Enrico Longato

We study the causal effect with a functional treatment variable, where practical applications often arise in neuroscience, biomedical sciences, etc. Previous research concerning the effect of a functional variable on an outcome is typically…

Methodology · Statistics 2025-05-20 Ruoxu Tan , Wei Huang , Zheng Zhang , Guosheng Yin

Introduction: For COVID-19 patients accurate prediction of disease severity and mortality risk would greatly improve care delivery and resource allocation. There are many patient-related factors, such as pre-existing comorbidities that…

Stroke is widely considered as the second most common cause of mortality. The adverse consequences of stroke have led to global interest and work for improving the management and diagnosis of stroke. Various techniques for data mining have…

Machine Learning · Computer Science 2021-10-22 Muhammad Salman Pathan , Jianbiao Zhang , Deepu John , Avishek Nag , Soumyabrata Dev

Electronic medical records (EMR) contain longitudinal information about patients that can be used to analyze outcomes. Typically, studies on EMR data have worked with established variables that have already been acknowledged to be…

Machine Learning · Computer Science 2017-11-30 Prithwish Chakraborty , Vishrawas Gopalakrishnan , Sharon M. H. Alford , Faisal Farooq

Many clinical deep learning algorithms are population-based and difficult to interpret. Such properties limit their clinical utility as population-based findings may not generalize to individual patients and physicians are reluctant to…

Signal Processing · Electrical Eng. & Systems 2020-12-01 Dani Kiyasseh , Tingting Zhu , David A. Clifton

Breast cancer remains a significant global health challenge, with prognosis and treatment decisions largely dependent on clinical characteristics. Accurate prediction of patient outcomes is crucial for personalized treatment strategies.…

A ubiquitous task in processing electronic medical data is the assignment of standardized codes representing diagnoses and/or procedures to free-text documents such as medical reports. This is a difficult natural language processing task…