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The extraction and standardization of pharmacokinetic (PK) information from scientific literature remain significant challenges in computational pharmacology, which limits the reliability of data-driven models in drug development. Large…

Machine Learning · Computer Science 2025-10-10 Majid Jaberi-Douraki , Hossein Sholehrasa , Xuan Xu , Remya Ampadi Ramachandran

Algorithmic trading requires short-term tactical decisions consistent with long-term financial objectives. Reinforcement Learning (RL) has been applied to such problems, but adoption is limited by myopic behaviour and opaque policies. Large…

Machine Learning · Computer Science 2025-10-28 Adam Darmanin , Vince Vella

Recent research explores optimization using large language models (LLMs) by either iteratively seeking next-step solutions from LLMs or directly prompting LLMs for an optimizer. However, these approaches exhibit inherent limitations,…

Optimization and Control · Mathematics 2024-03-06 Zeyuan Ma , Hongshu Guo , Jiacheng Chen , Guojun Peng , Zhiguang Cao , Yining Ma , Yue-Jiao Gong

Learned Optimizers (LOs), a type of Meta-learning, have gained traction due to their ability to be parameterized and trained for efficient optimization. Traditional gradient-based methods incorporate explicit regularization techniques such…

Machine Learning · Computer Science 2025-10-13 Suraj Kumar Sahoo , Narayanan C Krishnan

To ensure that text generated by large language models (LLMs) is in an expected format, constrained decoding proposes to enforce strict formal language constraints during generation. However, as we show in this work, not only do such…

Machine Learning · Computer Science 2024-03-13 Luca Beurer-Kellner , Marc Fischer , Martin Vechev

Model-based reinforcement learning (RL) is considered to be a promising approach to reduce the sample complexity that hinders model-free RL. However, the theoretical understanding of such methods has been rather limited. This paper…

Machine Learning · Computer Science 2021-02-16 Yuping Luo , Huazhe Xu , Yuanzhi Li , Yuandong Tian , Trevor Darrell , Tengyu Ma

Large Language Models (LLMs) have shown remarkable success, and their multimodal expansions (MLLMs) further unlock capabilities spanning images, videos, and other modalities beyond text. However, despite this shift, prompt optimization…

Machine Learning · Computer Science 2026-02-20 Yumin Choi , Dongki Kim , Jinheon Baek , Sung Ju Hwang

Tackling complex optimization problems often relies on expert-designed heuristics, typically crafted through extensive trial and error. Recent advances demonstrate that large language models (LLMs), when integrated into well-designed…

Neural and Evolutionary Computing · Computer Science 2025-05-20 Ziyao Huang , Weiwei Wu , Kui Wu , Jianping Wang , Wei-Bin Lee

Large language models (LLMs) have shown strong performance in many reasoning benchmarks. However, recent studies have pointed to memorization, rather than generalization, as one of the leading causes for such performance. LLMs, in fact, are…

Computation and Language · Computer Science 2025-09-19 Xingwei Tan , Marco Valentino , Mahmud Akhter , Maria Liakata , Nikolaos Aletras

The rapid advancement of large-language models (LLMs) has driven extensive research into parameter compression after training has been completed, yet compression during the training phase remains largely unexplored. In this work, we…

Machine Learning · Computer Science 2025-11-19 Jun Wu , Jiangtao Wen , Yuxing Han

Recent advanced large language models (LLMs) have showcased their emergent capability of in-context learning, facilitating intelligent decision-making through natural language prompts without retraining. This new machine learning paradigm…

Computational Engineering, Finance, and Science · Computer Science 2024-12-12 Xinxin Zhang , Zhuoqun Xu , Guangpu Zhu , Chien Ming Jonathan Tay , Yongdong Cui , Boo Cheong Khoo , Lailai Zhu

Quantizing large language models has become a standard way to reduce their memory and computational costs. Typically, existing methods focus on breaking down the problem into individual layer-wise sub-problems, and minimizing per-layer…

Machine Learning · Computer Science 2024-11-27 Vladimir Malinovskii , Andrei Panferov , Ivan Ilin , Han Guo , Peter Richtárik , Dan Alistarh

Although large language models (LLMs) have achieved great success in vast real-world applications, their vulnerabilities towards noisy inputs have significantly limited their uses, especially in high-stake environments. In these contexts,…

Computation and Language · Computer Science 2023-07-17 Zhen Zhang , Guanhua Zhang , Bairu Hou , Wenqi Fan , Qing Li , Sijia Liu , Yang Zhang , Shiyu Chang

Recent advancements in reasoning-focused language models such as OpenAI's O1 and DeepSeek-R1 have shown that scaling test-time computation-through chain-of-thought reasoning and iterative exploration-can yield substantial improvements on…

Mathematical reasoning is essential for problem-solving in education, science, and industry, serving as a crucial benchmark for evaluating artificial intelligence systems. As Large Language Models (LLMs) improve their reasoning…

Computation and Language · Computer Science 2026-05-20 Husnain Amjad , Raja Khurram Shahzad , Aamir Shahzad , Mehwish Fatima

We study reinforcement learning (RL) fine-tuning of large language model (LLM) agents for long-horizon multi-turn tool use, where context length quickly becomes a fundamental bottleneck. Existing RL pipelines can suffer from degraded…

Computation and Language · Computer Science 2025-10-09 Miao Lu , Weiwei Sun , Weihua Du , Zhan Ling , Xuesong Yao , Kang Liu , Jiecao Chen

Reasoning-oriented large language models (RLMs) achieve strong gains on tasks such as mathematics and coding by generating explicit intermediate reasoning. However, their impact on machine translation (MT) remains underexplored. We…

Computation and Language · Computer Science 2026-02-17 Sara Rajaee , Sebastian Vincent , Alexandre Berard , Marzieh Fadaee , Kelly Marchisio , Tom Kocmi

Large Language Models (LLMs) have recently demonstrated impressive capabilities across various real-world applications. However, due to the current text-in-text-out paradigm, it remains challenging for LLMs to handle dynamic and complex…

Artificial Intelligence · Computer Science 2024-10-25 Timothy Wei , Annabelle Miin , Anastasia Miin

Large pre-trained models, such as large language models (LLMs), present significant resource challenges for fine-tuning due to their extensive parameter sizes, especially for applications in mobile systems. To address this, Low-Rank…

Machine Learning · Computer Science 2024-07-18 Yuzhu Mao , Siqi Ping , Zihao Zhao , Yang Liu , Wenbo Ding

The scaling laws have become the de facto guidelines for designing large language models (LLMs), but they were studied under the assumption of unlimited computing resources for both training and inference. As LLMs are increasingly used as…