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Historically, neuroscience has progressed by fragmenting into specialized domains, each focusing on isolated modalities, tasks, or brain regions. While fruitful, this approach hinders the development of a unified model of cognition. Here,…

Machine Learning · Computer Science 2025-07-31 Stéphane d'Ascoli , Jérémy Rapin , Yohann Benchetrit , Hubert Banville , Jean-Rémi King

Brain encoder models predict cortical fMRI responses from the internal activations of pretrained vision and language networks, and are typically evaluated by held-out prediction accuracy. This is a useful signal for training but a poor one…

Neurons and Cognition · Quantitative Biology 2026-05-15 Stuart Bladon , Brinnae Bent

Multimodal learning, especially large-scale multimodal pre-training, has developed rapidly over the past few years and led to the greatest advances in artificial intelligence (AI). Despite its effectiveness, understanding the underlying…

Neural and Evolutionary Computing · Computer Science 2022-08-18 Haoyu Lu , Qiongyi Zhou , Nanyi Fei , Zhiwu Lu , Mingyu Ding , Jingyuan Wen , Changde Du , Xin Zhao , Hao Sun , Huiguang He , Ji-Rong Wen

Neuroscience research has made immense progress over the last decade, but our understanding of the brain remains fragmented and piecemeal: the dream of probing an arbitrary brain region and automatically reading out the information encoded…

Establishing stable mappings between natural language expressions and visual percepts is a foundational problem for both cognitive science and artificial intelligence. Humans routinely ground linguistic reference in noisy, ambiguous…

Artificial Intelligence · Computer Science 2026-02-24 Joseph Bingham

Foundation models of brain activity promise a new frontier for in silico neuroscience by emulating neural responses to complex stimuli across tasks and modalities. A natural next step is to ask whether these models can also be used in…

Machine Learning · Computer Science 2026-04-30 Niels Bracher , Xavier Intes , Stefan T. Radev

A reliable foundation model of functional neuroimages is critical to promote clinical applications where the performance of current AI models is significantly impeded by a limited sample size. To that end, tremendous efforts have been made…

Machine Learning · Computer Science 2025-10-23 Ziquan Wei , Tingting Dan , Guorong Wu

Predicting brain activity in response to naturalistic, multimodal stimuli is a key challenge in computational neuroscience. While encoding models are becoming more powerful, their ability to generalize to truly novel contexts remains a…

Computer Vision and Pattern Recognition · Computer Science 2025-07-28 Hamid Abdollahi , Amir Hossein Mansouri Majoumerd , Amir Hossein Bagheri Baboukani , Amir Abolfazl Suratgar , Mohammad Bagher Menhaj

In the pursuit to understand the intricacies of human brain's visual processing, reconstructing dynamic visual experiences from brain activities emerges as a challenging yet fascinating endeavor. While recent advancements have achieved…

Computer Vision and Pattern Recognition · Computer Science 2024-05-14 Jingyuan Sun , Mingxiao Li , Zijiao Chen , Marie-Francine Moens

Scaling data and artificial neural networks has transformed AI, driving breakthroughs in language and vision. Whether similar principles apply to modeling brain activity remains unclear. Here we leveraged a dataset of 3.1 million neurons…

In this study, we present a multimodal framework for predicting neuro-facial disorders by capturing both vocal and facial cues. We hypothesize that explicitly disentangling shared and modality-specific representations within multimodal…

Audio and Speech Processing · Electrical Eng. & Systems 2026-01-13 Mohd Mujtaba Akhtar , Girish , Muskaan Singh

We address prevailing challenges of the brain-powered research, departing from the observation that the literature hardly recover accurate spatial information and require subject-specific models. To address these challenges, we propose…

Computer Vision and Pattern Recognition · Computer Science 2024-07-19 Weihao Xia , Raoul de Charette , Cengiz Öztireli , Jing-Hao Xue

Foundation models in artificial intelligence (AI) are transforming medical imaging by enabling general-purpose feature learning from large-scale, unlabeled datasets. In this work, we introduce BrainFound, a self-supervised foundation model…

Computer Vision and Pattern Recognition · Computer Science 2026-01-01 Moona Mazher , Geoff J. M. Parker , Daniel C. Alexander

Self-supervised language and audio models effectively predict brain responses to speech. However, traditional prediction models rely on linear mappings from unimodal features, despite the complex integration of auditory signals with…

Computation and Language · Computer Science 2025-02-19 Danny Dongyeop Han , Yunju Cho , Jiook Cha , Jay-Yoon Lee

Our ability to use deep learning approaches to decipher neural activity would likely benefit from greater scale, in terms of both model size and datasets. However, the integration of many neural recordings into one unified model is…

Recent advances in Large Multimodal Models (LMMs) have expanded their capabilities to video understanding, with Text-to-Video (T2V) models excelling in generating videos from textual prompts. However, they still frequently produce…

Despite participants engaging in unimodal stimuli, such as watching images or silent videos, recent work has demonstrated that multi-modal Transformer models can predict visual brain activity impressively well, even with incongruent…

Neurons and Cognition · Quantitative Biology 2025-05-27 Subba Reddy Oota , Khushbu Pahwa , Mounika Marreddy , Maneesh Singh , Manish Gupta , Bapi S. Raju

The phenomenal advances in large language models (LLMs) and other foundation models over the past few years have been based on optimizing large-scale transformer models on the surprisingly simple objective of minimizing next-token…

Artificial Intelligence · Computer Science 2025-12-30 Rajesh P. N. Rao , Vishwas Sathish , Linxing Preston Jiang , Matthew Bryan , Prashant Rangarajan

Decoding language from the human brain remains a grand challenge for Brain-Computer Interfaces (BCIs). Current approaches typically rely on unimodal brain representations, neglecting the brain's inherently multimodal processing. Inspired by…

Computation and Language · Computer Science 2025-08-12 Chunyu Ye , Yunhao Zhang , Jingyuan Sun , Chong Li , Chengqing Zong , Shaonan Wang

Brain MRI underpins a wide range of neuroscientific and clinical applications, yet most learning-based methods remain task-specific and require substantial labeled data. Here we show that a single self-supervised representation can…

Machine Learning · Computer Science 2026-05-27 Yizhou Wu , Shansong Wang , Yuheng Li , Mojtaba Safari , Mingzhe Hu , Chih-Wei Chang , Harini Veeraraghavan , Xiaofeng Yang
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