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Molecular phylogenetic techniques do not generally account for such common evolutionary events as site insertions and deletions (known as indels). Instead tree building algorithms and ancestral state inference procedures typically rely on…

Probability · Mathematics 2011-09-07 Alexandr Andoni , Constantinos Daskalakis , Avinatan Hassidim , Sebastien Roch

The ancestral sequence reconstruction problem is the inference, back in time, of the properties of common sequence ancestors from measured properties of contemporary populations. Standard algorithms for this problem assume independent…

Disordered Systems and Neural Networks · Physics 2022-02-09 Edwin Rodríguez Horta , Alejandro Lage-Castellanos , Roberto Mulet

Automatic Speech Recognition (ASR) traditionally assumes known domains, but adding data from a new domain raises concerns about computational inefficiencies linked to retraining models on both existing and new domains. Fine-tuning solely on…

Computation and Language · Computer Science 2024-09-25 Devang Kulshreshtha , Saket Dingliwal , Brady Houston , Nikolaos Pappas , Srikanth Ronanki

Ancestral sequence reconstruction is a key task in computational biology. It consists in inferring a molecular sequence at an ancestral species of a known phylogeny, given descendant sequences at the tip of the tree. In addition to its many…

Populations and Evolution · Quantitative Biology 2022-07-27 Brandon Legried , Sebastien Roch

Autoregressive generative models naturally generate variable-length sequences, while non-autoregressive models struggle, often imposing rigid, token-wise structures. We propose Edit Flows, a non-autoregressive model that overcomes these…

Machine Learning · Computer Science 2025-11-13 Marton Havasi , Brian Karrer , Itai Gat , Ricky T. Q. Chen

Recovering a tree that represents the evolutionary history of a group of species is a key task in phylogenetics. Performing this task using sequence data from multiple genetic markers poses two key challenges. The first is the discordance…

Populations and Evolution · Quantitative Biology 2026-03-12 Ortal Reshef , Ofer Glassman , Or Zuk , Yariv Aizenbud , Boaz Nadler , Ariel Jaffe

We establish necessary and sufficient conditions for consistent root reconstruction in continuous-time Markov models with countable state space on bounded-height trees. Here a root state estimator is said to be consistent if the probability…

Probability · Mathematics 2019-08-02 Wai-Tong Louis Fan , Sebastien Roch

We propose a monitoring mechanism for recording the evolution of systems after certain computations, maintaining the history in a tree-like structure. Technically, we develop the monitoring mechanism in a variant of ADR (after Architectural…

Software Engineering · Computer Science 2013-10-18 Kyriakos Poyias , Emilio Tuosto

There is often a trade-off between performance and latency in streaming automatic speech recognition (ASR). Traditional methods such as look-ahead and chunk-based methods, usually require information from future frames to advance…

Audio and Speech Processing · Electrical Eng. & Systems 2022-07-07 Zehan Li , Haoran Miao , Keqi Deng , Gaofeng Cheng , Sanli Tian , Ta Li , Yonghong Yan

The complex correlation structure of a collection of orthologous DNA sequences is uniquely captured by the "ancestral recombination graph" (ARG), a complete record of coalescence and recombination events in the history of the sample.…

Populations and Evolution · Quantitative Biology 2013-12-04 Matthew D. Rasmussen , Melissa J. Hubisz , Ilan Gronau , Adam Siepel

While most neural generative models generate outputs in a single pass, the human creative process is usually one of iterative building and refinement. Recent work has proposed models of editing processes, but these mostly focus on editing…

Machine Learning · Computer Science 2021-03-08 Ziyu Yao , Frank F. Xu , Pengcheng Yin , Huan Sun , Graham Neubig

We introduce EvoFlows, a variable-length protein sequence-to-sequence modeling approach designed for protein engineering. Existing protein language models are poorly suited for optimization tasks: autoregressive models require full sequence…

Machine Learning · Computer Science 2026-04-09 Nicolas Deutschmann , Constance Ferragu , Jonathan D. Ziegler , Shayan Aziznejad , Eli Bixby

An evolutionary tree is a cascade of bifurcations starting from a single common root, generating a growing set of daughter species as time goes by. Species here is a general denomination for biological species, spoken languages or any other…

Quantitative Methods · Quantitative Biology 2013-08-26 Paulo Murilo Castro de Oliveira

Given natural limitations on the length DNA sequences, designing phylogenetic reconstruction methods which are reliable under limited information is a crucial endeavor. There have been two approaches to this problem: reconstructing partial…

Data Structures and Algorithms · Computer Science 2008-12-10 Radu Mihaescu , Cameron Hill , Satish Rao

Automatic Speech Recognition (ASR) is an integral component of modern technology, powering applications such as voice-activated assistants, transcription services, and accessibility tools. Yet ASR systems continue to struggle with the…

Audio and Speech Processing · Electrical Eng. & Systems 2026-05-20 Mohammad Reza Peyghan , Saman Soleimani Roudi , Saeedreza Zouashkiani , Sajjad Amini , Fatemeh Rajabi , Shahrokh Ghaemmaghami

Error correction techniques have been used to refine the output sentences from automatic speech recognition (ASR) models and achieve a lower word error rate (WER) than original ASR outputs. Previous works usually use a sequence-to-sequence…

Computation and Language · Computer Science 2022-11-30 Yichong Leng , Xu Tan , Linchen Zhu , Jin Xu , Renqian Luo , Linquan Liu , Tao Qin , Xiang-Yang Li , Ed Lin , Tie-Yan Liu

Neural network pruning offers an effective method for compressing a multilingual automatic speech recognition (ASR) model with minimal performance loss. However, it entails several rounds of pruning and re-training needed to be run for each…

Audio and Speech Processing · Electrical Eng. & Systems 2025-06-19 Jiamin Xie , Ke Li , Jinxi Guo , Andros Tjandra , Yuan Shangguan , Leda Sari , Chunyang Wu , Junteng Jia , Jay Mahadeokar , Ozlem Kalinli

This thesis presents Regenerative Rejection Sampling (RRS), a novel approximate sampling algorithm inspired by classical Rejection Sampling and Markov Chain Monte Carlo methods. The method constructs a continuous-time regenerative process…

Computation · Statistics 2026-04-01 Tommaso Bozzi

Recent advances in flow-based generative models have enabled training-free, text-guided image editing by inverting an image into its latent noise and regenerating it under a new target conditional guidance. However, existing methods…

Computer Vision and Pattern Recognition · Computer Science 2026-04-03 Thinh Dao , Zhen Wang , Kien T. Pham , Long Chen

A method based on mapping a symbolic sequence into a set of patterns (strings resulting from the sequence parsing) is proposed as a tool for the reconstruction of ancestral sequences. The set union of patterns comprises all the patterns…

Genomics · Quantitative Biology 2015-04-16 Bohdan Kozarzewski
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