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Large language models are increasingly embedded in regulated and safety-critical software, including clinical research platforms and healthcare information systems. While these features enable natural language search, summarization, and…

Software Engineering · Computer Science 2026-02-02 Zhiyin Zhou

The adoption of machine learning (ML) and, more specifically, deep learning (DL) applications into all major areas of our lives is underway. The development of trustworthy AI is especially important in medicine due to the large implications…

Machine Learning · Computer Science 2024-02-22 Daniel Schwabe , Katinka Becker , Martin Seyferth , Andreas Klaß , Tobias Schäffter

Recent breakthroughs in large language models (LLMs) have generated both interest and concern about their potential adoption as information sources or communication tools across different domains. In public health, where stakes are high and…

Human-Computer Interaction · Computer Science 2025-10-16 Jiawei Zhou , Amy Z. Chen , Darshi Shah , Laura M. Schwab Reese , Munmun De Choudhury

In this paper we present the first investigation into the effectiveness of Large Language Models (LLMs) for Failure Mode Classification (FMC). FMC, the task of automatically labelling an observation with a corresponding failure mode code,…

Computation and Language · Computer Science 2023-09-18 Michael Stewart , Melinda Hodkiewicz , Sirui Li

Brief hospital course (BHC) summaries are clinical documents that summarize a patient's hospital stay. While large language models (LLMs) depict remarkable capabilities in automating real-world tasks, their capabilities for healthcare…

This paper provides a comprehensive review of the future of cybersecurity through Generative AI and Large Language Models (LLMs). We explore LLM applications across various domains, including hardware design security, intrusion detection,…

Large Language Models (LLMs) are increasingly integrated into vehicle-based digital assistants, where unsafe, ambiguous, or legally incorrect responses can lead to serious safety, ethical, and regulatory consequences. Despite growing…

Artificial Intelligence · Computer Science 2026-03-25 Abhishek Kumar , Riya Tapwal , Carsten Maple

While increasing patients' access to medical documents improves medical care, this benefit is limited by varying health literacy levels and complex medical terminology. Large language models (LLMs) offer solutions by simplifying medical…

Computation and Language · Computer Science 2025-02-06 Amin Dada , Osman Alperen Koras , Marie Bauer , Amanda Butler , Kaleb E. Smith , Jens Kleesiek , Julian Friedrich

With the widespread application of Large Language Models (LLMs), their associated security issues have become increasingly prominent, severely constraining their trustworthy deployment in critical domains. This paper proposes a novel safety…

Artificial Intelligence · Computer Science 2025-11-18 Qi Li , Jianjun Xu , Pingtao Wei , Jiu Li , Peiqiang Zhao , Jiwei Shi , Xuan Zhang , Yanhui Yang , Xiaodong Hui , Peng Xu , Wenqin Shao

Most safety testing efforts for large language models (LLMs) today focus on evaluating foundation models. However, there is a growing need to evaluate safety at the application level, as components such as system prompts, retrieval…

Software Engineering · Computer Science 2025-07-15 Jia Yi Goh , Shaun Khoo , Nyx Iskandar , Gabriel Chua , Leanne Tan , Jessica Foo

Integrating large language models (LLMs) into patient-facing healthcare systems offers significant potential to improve access to medical information. However, ensuring clinical safety and factual reliability remains a critical challenge.…

Computers and Society · Computer Science 2026-05-01 Elham Nasarian , Abhilash Neog , Kwok-Leung Tsui , Niyousha HosseiniChimeh

As Large Language Models (LLMs) continue to advance in understanding and generating long sequences, new safety concerns have been introduced through the long context. However, the safety of LLMs in long-context tasks remains under-explored,…

Computation and Language · Computer Science 2025-02-25 Yida Lu , Jiale Cheng , Zhexin Zhang , Shiyao Cui , Cunxiang Wang , Xiaotao Gu , Yuxiao Dong , Jie Tang , Hongning Wang , Minlie Huang

Integrating large language models (LLMs) like DeepSeek R1 into healthcare requires rigorous evaluation of their reasoning alignment with clinical expertise. This study assesses DeepSeek R1's medical reasoning against expert patterns using…

Computation and Language · Computer Science 2025-04-02 Birger Moell , Fredrik Sand Aronsson , Sanian Akbar

Static benchmarks for harmful content detection face limitations in scalability and diversity, and may also be affected by contamination from web-scale pre-training corpora. To address these issues, we propose a framework for synthesizing…

Computation and Language · Computer Science 2026-04-21 Huije Lee , Jisu Shin , Hoyun Song , Changgeon Ko , Jong C. Park

Timely and accurate situational reports are essential for humanitarian decision-making, yet current workflows remain largely manual, resource intensive, and inconsistent. We present a fully automated framework that uses large language…

Computation and Language · Computer Science 2025-12-23 Ivan Decostanzi , Yelena Mejova , Kyriaki Kalimeri

Despite their impressive performance, large language models (LLMs) such as ChatGPT are known to pose important risks. One such set of risks arises from misplaced confidence, whether over-confidence or under-confidence, that the models have…

Computation and Language · Computer Science 2024-08-06 Ke Shen , Mayank Kejriwal

Large Language Models (LLMs) show potential for medical applications but often lack specialized clinical knowledge. Retrieval Augmented Generation (RAG) allows customization with domain-specific information, making it suitable for…

Large language models (LLMs), including zero-shot and few-shot paradigms, have shown promising capabilities in clinical text generation. However, real-world applications face two key challenges: (1) patient data is highly unstructured,…

Computation and Language · Computer Science 2025-07-10 Garapati Keerthana , Manik Gupta

Large language models (LLMs) are increasingly deployed in medical contexts, raising critical concerns about safety, alignment, and susceptibility to adversarial manipulation. While prior benchmarks assess model refusal capabilities for…

Computation and Language · Computer Science 2025-05-19 Sijia Chen , Xiaomin Li , Mengxue Zhang , Eric Hanchen Jiang , Qingcheng Zeng , Chen-Hsiang Yu

As Large Language Models (LLMs) are increasingly deployed in healthcare field, it becomes essential to carefully evaluate their medical safety before clinical use. However, existing safety benchmarks remain predominantly English-centric,…

Computation and Language · Computer Science 2026-05-28 Junyu Liu , Zirui Li , Qian Niu , Zequn Zhang , Yue Xun , Wenlong Hou , Shujun Wang , Yusuke Iwasawa , Yutaka Matsuo , Kan Hatakeyama-Sato
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