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Motivation: High-throughput sequencing (HTS) enables population-scale genomics but generates massive datasets, creating bottlenecks in storage, transfer, and analysis. FASTQ, the standard format for over two decades, stores one byte per…

Recent advancements in neural network quantisation have yielded remarkable outcomes, with three-bit networks reaching state-of-the-art full-precision accuracy in complex tasks. These achievements present valuable opportunities for…

Hardware Architecture · Computer Science 2024-03-19 Daniel Gerlinghoff , Benjamin Chen Ming Choong , Rick Siow Mong Goh , Weng-Fai Wong , Tao Luo

Scaling model size significantly challenges the deployment and inference of Large Language Models (LLMs). Due to the redundancy in LLM weights, recent research has focused on pushing weight-only quantization to extremely low-bit (even down…

Artificial Intelligence · Computer Science 2024-10-23 Yifei Liu , Jicheng Wen , Yang Wang , Shengyu Ye , Li Lyna Zhang , Ting Cao , Cheng Li , Mao Yang

A growing trend has emerged in designing high-quality Small Language Models (SLMs) with a few million parameters. This trend is driven by the increasing concerns over cloud costs, privacy, and latency. Considering that full parameter…

Machine Learning · Computer Science 2025-07-03 Xuan Shen , Peiyan Dong , Zhenglun Kong , Yifan Gong , Changdi Yang , Zhaoyang Han , Yanyue Xie , Lei Lu , Cheng Lyu , Chao Wu , Yanzhi Wang , Pu Zhao

Transformer-based large language models (LLMs) have achieved remarkable success as model sizes continue to grow, yet their deployment remains challenging due to significant computational and memory demands. Quantization has emerged as a…

Machine Learning · Computer Science 2024-11-26 Yu Zhang , Mingzi Wang , Lancheng Zou , Wulong Liu , Hui-Ling Zhen , Mingxuan Yuan , Bei Yu

Although Multimodal Large Language Models (MLLMs) have demonstrated remarkable capabilities in vision, language, and video understanding tasks, scaling them to long-form speech remains a critical bottleneck due to the explosive growth of…

Audio and Speech Processing · Electrical Eng. & Systems 2026-02-03 Junseok Lee , Sangyong Lee , Chang-Jae Chun

We study weight-only post-training quantization (PTQ), which quantizes the weights of a large language model (LLM) without retraining, using little or no calibration data. Weight-only PTQ is crucial for reducing the memory footprint and…

Machine Learning · Computer Science 2025-10-23 Deokjae Lee , Hyun Oh Song

Quantization of Large Language Models (LLMs) has recently gained popularity, particularly for on-device settings with limited hardware resources. While efficient, quantization inevitably degrades model quality, especially in aggressive…

Machine Learning · Computer Science 2025-06-25 Yeonhong Park , Jake Hyun , Hojoon Kim , Jae W. Lee

Deploying large language models (LLMs) on end-user devices is gaining importance due to benefits in responsiveness, privacy, and operational cost. Yet the limited memory and compute capability of mobile and desktop GPUs make efficient…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-11-07 Rongxiang Wang , Kangyuan Shu , Felix Xiaozhu Lin

Efficient deployment of large language models (LLMs) necessitates low-bit quantization to minimize model size and inference cost. While low-bit integer formats (e.g., INT8/INT4) have been the conventional choice, emerging low-bit…

Machine Learning · Computer Science 2023-05-23 Yijia Zhang , Lingran Zhao , Shijie Cao , Wenqiang Wang , Ting Cao , Fan Yang , Mao Yang , Shanghang Zhang , Ningyi Xu

Large language models (LLMs) show excellent performance but are compute- and memory-intensive. Quantization can reduce memory and accelerate inference. However, existing methods cannot maintain accuracy and hardware efficiency at the same…

Computation and Language · Computer Science 2024-04-03 Guangxuan Xiao , Ji Lin , Mickael Seznec , Hao Wu , Julien Demouth , Song Han

The rapid growth of large language models (LLMs) has outpaced the memory constraints of edge devices, necessitating extreme weight compression beyond the 1-bit limit. While quantization reduces model size, it is fundamentally limited to 1…

Machine Learning · Computer Science 2025-06-24 Sunan Zou , Ziyun Zhang , Xueting Sun , Guojie Luo

Large language models (LLMs) have demonstrated remarkable capabilities in various kinds of tasks, while the billion or even trillion parameters bring storage and efficiency bottlenecks for inference. Quantization, particularly…

Machine Learning · Computer Science 2025-10-21 Mengtao Lv , Ruiqi Zhu , Xinyu Wang , Yun Li

We explore the industrial and scientific applicability of the VQE-LSTM framework by integrating meta-learning with GPU accelerated quantum simulation using NVIDIA's CUDA-Q (CUDAQ) platform. This work demonstrates how an LSTM-FC…

Quantum Physics · Physics 2026-02-18 Yun-Hsuan Chen , Jen-Yu Chang , Tsung-Wei Huang , En-Jui Kuo

Large language models (LLMs) face significant computational and memory challenges, making extremely low-bit quantization crucial for their efficient deployment. In this work, we introduce SDQ-LLM: Sigma-Delta Quantization for 1-bit LLMs of…

Machine Learning · Computer Science 2025-10-07 Junhao Xia , Ming Zhao , Limin Xiao , Xiujun Zhang

Quantization techniques such as BitsAndBytes, AWQ, and GPTQ are widely used as a standard method in deploying large language models but often degrades accuracy when using low-bit representations, e.g., 4 bits. Low-rank correction methods…

Machine Learning · Computer Science 2026-05-01 Selim An , Il hong Suh , Yeseong Kim

With the rapid growth in the use of fine-tuning for large language models (LLMs), optimizing fine-tuning while keeping inference efficient has become highly important. However, this is a challenging task as it requires improvements in all…

Computation and Language · Computer Science 2024-10-14 Changhun Lee , Jun-gyu Jin , Younghyun Cho , Eunhyeok Park

Quantization and fine-tuning are crucial for deploying large language models (LLMs) on resource-constrained edge devices. However, fine-tuning quantized models presents significant challenges, primarily stemming from: First, the mismatch in…

Machine Learning · Computer Science 2025-09-30 Junyu Chen , Junzhuo Li , Zhen Peng , Wenjie Wang , Yuxiang Ren , Long Shi , Xuming Hu

Recent breakthroughs in Large-scale language models (LLMs) have demonstrated impressive performance on various tasks. The immense sizes of LLMs have led to very high resource demand and cost for running the models. Though the models are…

Machine Learning · Computer Science 2024-03-05 Juntao Zhao , Borui Wan , Yanghua Peng , Haibin Lin , Chuan Wu

Current quantization methods for LLMs predominantly rely on block-wise structures to maintain efficiency, often at the cost of representational flexibility. In this work, we demonstrate that element-wise quantization can be made as…

Machine Learning · Computer Science 2026-02-02 Pingzhi Tang , Ruijie Zhou , Fanxu Meng , Wenjie Pei , Muhan Zhang