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Machine Learning Interatomic Potentials (MLIPs) achieve near ab initio accuracy at a fraction of the cost of quantum-mechanical simulations, yet they remain prone to silent failures on out-of-distribution configurations, making principled…

Computational Engineering, Finance, and Science · Computer Science 2026-05-27 Olga Zaghen , Maksim Zhdanov , Dario Coscia , David R. Wessels , Erik J. Bekkers

Accurate structural relaxation is critical for advanced materials design. Traditional approaches built on physics-derived first-principles calculations are computationally expensive, motivating the creation of machine-learning interatomic…

Machine-learned potentials (MLPs) trained on ab initio data combine the computational efficiency of classical interatomic potentials with the accuracy and generality of the first-principles method used in the creation of the respective…

Chemical Physics · Physics 2024-08-07 Leonid Kahle , Benoit Minisini , Tai Bui , Jeremy T. First , Corneliu Buda , Thomas Goldman , Erich Wimmer

Machine learning interatomic potentials (MLIPs) have substantially advanced atomistic simulations in materials science and chemistry by balancing accuracy and computational efficiency. While leading MLIPs rely on representing atomic…

Materials Science · Physics 2025-05-05 Mingjian Wen , Wei-Fan Huang , Jin Dai , Santosh Adhikari

Machine learning interatomic potentials (MLIPs) offer near-ab initio accuracy with the efficiency of classical force fields, making them attractive for modeling electrolytes. Collecting a diverse training set is essential for their accuracy…

Chemical Physics · Physics 2025-10-07 Olga Chalykh , Mikhail Polovinkin , Dmitry Korogod , Nikita Rybin , Alexander Shapeev

Large Language Models (LLMs) are discovered to suffer from accurately retrieving key information. To address this, we propose Mask-Enhanced Autoregressive Prediction (MEAP), a simple yet effective training paradigm that seamlessly…

Computation and Language · Computer Science 2026-03-16 Xialie Zhuang , Zhikai Jia , Jianjin Li , Zhenyu Zhang , Li Shen , Zheng Cao , Shiwei Liu

Accurate and scalable machine-learned inter-atomic potentials (MLIPs) are essential for molecular simulations ranging from drug discovery to new material design. Current state-of-the-art models enforce roto-translational symmetries through…

The vastness of chemical space makes generalization a central challenge in the development of machine learning interatomic potentials (MLIPs). While MLIPs could enable large-scale atomistic simulations with near-quantum accuracy, their…

Chemical Physics · Physics 2026-03-20 Michal Sanocki , Julija Zavadlav

We introduce an explorative active learning (AL) algorithm based on Gaussian process regression and marginalized graph kernel (GPR-MGK) to explore chemical space with minimum cost. Using high-throughput molecular dynamics simulation to…

Machine Learning · Computer Science 2022-09-02 Yan Xiang , Yu-Hang Tang , Zheng Gong , Hongyi Liu , Liang Wu , Guang Lin , Huai Sun

Machine learning interatomic potentials (MLIPs) with broad chemical flexibility are important for atomistic simulations of compositionally complex materials such as high-entropy alloys. Here, we study two state-of-the-art MLIP frameworks,…

Materials Science · Physics 2026-04-06 Fei Shuang , Penghua Ying , Kai Liu , Zixiong Wei , Fengxian Liu , Zheyong Fan , Minqiang Jiang , Poulumi Dey

Achieving higher operational voltages, faster charging, and broader temperature ranges for Li-ion batteries necessitates advancements in electrolyte engineering. However, the complexity of optimizing combinations of solvents, salts, and…

Materials Science · Physics 2025-01-10 Suyeon Ju , Jinmu You , Gijin Kim , Yutack Park , Hyungmin An , Seungwu Han

Masked Image Modeling (MIM) has emerged as a promising method for deriving visual representations from unlabeled image data by predicting missing pixels from masked portions of images. It excels in region-aware learning and provides strong…

Computer Vision and Pattern Recognition · Computer Science 2024-07-23 Yibing Wei , Abhinav Gupta , Pedro Morgado

Machine Learning Interatomic Potentials (MLIPs) are becoming a central tool in simulation-based chemistry. However, like most deep learning models, MLIPs struggle to make accurate predictions on out-of-distribution data or when trained in a…

Machine Learning · Computer Science 2026-01-19 Dario Coscia , Pim de Haan , Max Welling

The past few years have seen the development of ``universal'' machine-learning interatomic potentials (uMLIPs) capable of approximating the ground-state potential energy surface across a wide range of chemical structures and compositions…

Chemical Physics · Physics 2026-04-20 Sofiia Chorna , Davide Tisi , Cesare Malosso , Wei Bin How , Michele Ceriotti , Sanggyu Chong

Machine-learned interatomic potentials (MLIPs), particularly graph neural network (GNN)-based models, offer a promising route to achieving near-density functional theory (DFT) accuracy at significantly reduced computational cost. However,…

Machine learning interatomic potentials (MLIPs) enable efficient modeling of molecular interactions with quantum mechanical (QM) accuracy. However, constructing robust and representative training datasets that capture subtle,…

Chemical Physics · Physics 2026-01-28 Lejia Zeng , Xintong Zhang , Yuchan Pei , Lifeng Zhao , Lan Hua , Jincai Yang , Niu Huang

The Deep Learning revolution has enabled groundbreaking achievements in recent years. From breast cancer detection to protein folding, deep learning algorithms have been at the core of very important advancements. However, these modern…

Computer Vision and Pattern Recognition · Computer Science 2024-03-01 Bonaventure F. P. Dossou

Accurate molecular property predictions require 3D geometries, which are typically obtained using expensive methods such as density functional theory (DFT). Here, we attempt to obtain molecular geometries by relying solely on machine…

Molecular representation learning (MRL) is a fundamental task for drug discovery. However, previous deep-learning (DL) methods focus excessively on learning robust inner-molecular representations by mask-dominated pretraining framework,…

Biomolecules · Quantitative Biology 2023-06-16 Yu Wang , JingJie Zhang , Junru Jin , Leyi Wei

Strategies for machine-learning(ML)-accelerated discovery that are general across materials composition spaces are essential, but demonstrations of ML have been primarily limited to narrow composition variations. By addressing the scarcity…