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According to the National Cancer Institute, there were 9.5 million cancer-related deaths in 2018. A challenge in improving treatment is resistance in genetically unstable cells. The purpose of this study is to evaluate unsupervised machine…

Genomics · Quantitative Biology 2021-08-12 Anastasia Dunca , Frederick R. Adler

Inflammatory Bowel Disease (IBD), including Crohn's Disease (CD) and Ulcerative Colitis (UC), presents significant public health challenges due to its complex etiology. Motivated by the IBD study of the Integrative Human Microbiome Project,…

Applications · Statistics 2025-10-28 Limeng Liu , Guannan Wang , Sandra E. Safo

Over 30 papers have proposed to use convolutional neural network (CNN) for AD classification from anatomical MRI. However, the classification performance is difficult to compare across studies due to variations in components such as…

We explore whether survival model performance in underrepresented high- and low-risk subgroups - regions of the prognostic spectrum where clinical decisions are most consequential - can be improved through targeted restructuring of the…

Single-cell RNA sequencing (scRNA-seq) has revolutionized biological discovery, providing an unbiased picture of cellular heterogeneity in tissues. While scRNA-seq has been used extensively to provide insight into both healthy systems and…

Genomics · Quantitative Biology 2020-03-16 Neal G. Ravindra , Arijit Sehanobish , Jenna L. Pappalardo , David A. Hafler , David van Dijk

Unsupervised cell type identification is crucial for uncovering and characterizing heterogeneous populations in single cell omics studies. Although a range of clustering methods have been developed, most focus exclusively on intrinsic…

Artificial Intelligence · Computer Science 2025-12-12 Liang Peng , Haopeng Liu , Yixuan Ye , Cheng Liu , Wenjun Shen , Si Wu , Hau-San Wong

Objective: To improve prediction of Chronic Kidney Disease (CKD) progression to End Stage Renal Disease (ESRD) using machine learning (ML) and deep learning (DL) models applied to an integrated clinical and claims dataset of varying…

Quantitative Methods · Quantitative Biology 2025-05-06 Yubo Li , Rema Padman

Recent studies have applied deep learning methods such as convolutional recurrent neural networks (CRNs) and Transformers to brain disease classification based on dynamic functional connectivity networks (dFCNs), such as Alzheimer's disease…

Image and Video Processing · Electrical Eng. & Systems 2023-09-06 Zhixiang Zhang , Biao Jie , Zhengdong Wang , Jie Zhou , Yang Yang

International Classification of Diseases(ICD) is an authoritative health care classification system of different diseases and conditions for clinical and management purposes. Considering the complicated and dedicated process to assign…

Computation and Language · Computer Science 2022-01-13 Haoran Shi , Pengtao Xie , Zhiting Hu , Ming Zhang , Eric P. Xing

Unsupervised learning on high-dimensional RNA-seq data can reveal molecular subtypes beyond standard labels. We combine an autoencoder-based representation with clustering and stability analysis to search for rare but reproducible genomic…

Machine Learning · Computer Science 2025-11-18 Alaa Mezghiche

In the last few years, Deep Learning (DL) has been showing superior performance in different modalities of biomedical image analysis. Several DL architectures have been proposed for classification, segmentation, and detection tasks in…

Computer Vision and Pattern Recognition · Computer Science 2019-04-26 Md Zahangir Alom , Theus Aspiras , Tarek M. Taha , Vijayan K. Asari

Single-cell RNA sequencing (scRNA-seq) data analysis is pivotal for understanding cellular heterogeneity. However, the high sparsity and complex noise patterns inherent in scRNA-seq data present significant challenges for traditional…

Genomics · Quantitative Biology 2024-08-13 Wenwen Min , Zhen Wang , Fangfang Zhu , Taosheng Xu , Shunfang Wang

Reliable crop disease detection requires models that perform consistently across diverse acquisition conditions, yet existing evaluations often focus on single architectural families or lab-generated datasets. This work presents a…

Computer Vision and Pattern Recognition · Computer Science 2026-04-09 Hamza Mooraj , George Pantazopoulos , Alessandro Suglia

We present a fairness-aware framework for multi-class lung disease diagnosis from chest CT volumes, developed for the Fair Disease Diagnosis Challenge at the PHAROS-AIF-MIH Workshop (CVPR 2026). The challenge requires classifying CT scans…

Computer Vision and Pattern Recognition · Computer Science 2026-03-16 Aditya Parikh , Aasa Feragen

Weakly supervised disease classification of CT imaging suffers from poor localization owing to case-level annotations, where even a positive scan can hold hundreds to thousands of negative slices along multiple planes. Furthermore, although…

Computer Vision and Pattern Recognition · Computer Science 2020-11-03 Anindo Saha , Fakrul I. Tushar , Khrystyna Faryna , Vincent M. D'Anniballe , Rui Hou , Maciej A. Mazurowski , Geoffrey D. Rubin , Joseph Y. Lo

Crop yield production could be enhanced for agricultural growth if various plant nutrition deficiencies, and diseases are identified and detected at early stages. The deep learning methods have proven its superior performances in the…

Computer Vision and Pattern Recognition · Computer Science 2024-10-17 Asish Bera , Debotosh Bhattacharjee , Ondrej Krejcar

Skin cancer classification is a crucial task in medical image analysis, where precise differentiation between malignant and non-malignant lesions is essential for early diagnosis and treatment. In this study, we explore Sequential and…

Computer Vision and Pattern Recognition · Computer Science 2025-08-19 Shubhi Agarwal , Amulya Kumar Mahto

With ongoing developments and innovations in single-cell RNA sequencing methods, advancements in sequencing performance could empower significant discoveries as well as new emerging possibilities to address biological and medical…

Applications · Statistics 2019-12-19 Jiawei Long , Yu Xia

Crohn's disease (CD) is a chronic and relapsing inflammatory condition that affects segments of the gastrointestinal tract. CD activity is determined by histological findings, particularly the density of neutrophils observed on Hematoxylin…

Single-cell RNA sequencing (scRNA-seq) is widely used to reveal heterogeneity in cells, which has given us insights into cell-cell communication, cell differentiation, and differential gene expression. However, analyzing scRNA-seq data is a…

Machine Learning · Computer Science 2023-06-27 Yuta Hozumi , Gu-Wei Wei