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Revealing the clonal composition of a single tumor is essential for identifying cell subpopulations with metastatic potential in primary tumors or with resistance to therapies in metastatic tumors. Sequencing technologies provide an…

Genomics · Quantitative Biology 2014-02-07 Francesco Strino , Fabio Parisi , Mariann Micsinai , Yuval Kluger

While automated audio captioning (AAC) has made notable progress, traditional fully supervised AAC models still face two critical challenges: the need for expensive audio-text pair data for training and performance degradation when…

Sound · Computer Science 2025-01-07 Xiquan Li , Wenxi Chen , Ziyang Ma , Xuenan Xu , Yuzhe Liang , Zhisheng Zheng , Qiuqiang Kong , Xie Chen

Nowadays, we are living in an era of extreme device heterogeneity. Despite the high variety of conventional CPU architectures, accelerator devices, such as GPUs and FPGAs, also appear in the foreground exploding the pool of available…

Machine Learning · Computer Science 2022-08-31 Petros Vavaroutsos , Ioannis Oroutzoglou , Dimosthenis Masouros , Dimitrios Soudris

Achieving optimal program performance requires deep insight into the interaction between hardware and software. For software developers without an in-depth background in computer architecture, understanding and fully utilizing modern…

Performance · Computer Science 2018-07-09 Julian Hammer , Jan Eitzinger , Georg Hager , Gerhard Wellein

Arbitrary-precision integer multiplication is the core kernel of many applications in simulation, cryptography, etc. Existing acceleration of arbitrary-precision integer multiplication includes CPUs, GPUs, FPGAs, and ASICs. Among these…

Hardware Architecture · Computer Science 2023-09-22 Zhuoping Yang , Jinming Zhuang , Jiaqi Yin , Cunxi Yu , Alex K. Jones , Peipei Zhou

Deploying deep neural networks (DNNs) across homogeneous edge devices (the devices with the same SKU labeled by the manufacturer) often assumes identical performance among them. However, once a device model is widely deployed, the…

Hardware Architecture · Computer Science 2025-12-16 Kunlong Zhang , Guiying Li , Ning Lu , Peng Yang , Ke Tang

Parallel programming is central to HPC and AI, but producing code that is correct and fast remains challenging, especially for OpenMP GPU offload, where data movement and tuning dominate. Autonomous coding agents can compile, test, and…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-01-09 Erel Kaplan , Tomer Bitan , Lian Ghrayeb , Le Chen , Tom Yotam , Niranjan Hasabnis , Gal Oren

The challenge of mapping AI architectures to GPU hardware is creating a critical bottleneck in AI progress. Despite substantial efforts, hand-written custom kernels fail to meet their theoretical performance thresholds, even on…

Machine Learning · Computer Science 2024-10-29 Benjamin F. Spector , Simran Arora , Aaryan Singhal , Daniel Y. Fu , Christopher Ré

Large Language Model (LLM) inference services demand exceptionally high availability and low latency, yet multi-GPU Tensor Parallelism (TP) makes them vulnerable to single-GPU failures. We present AnchorTP, a state-preserving elastic TP…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-11-18 Wendong Xu , Chujie Chen , He Xiao , Kuan Li , Jing Xiong , Chen Zhang , Wenyong Zhou , Chaofan Tao , Yang Bai , Bei Yu , Ngai Wong

The escalating demand for high-fidelity, real-time inference in distributed edge-cloud environments necessitates aggressive model optimization to counteract severe latency and energy constraints. This paper introduces the Hybrid…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-02-09 Dinesh Gopalan , Ratul Ali

Training Large Language Models (LLMs) efficiently at scale presents a formidable challenge, driven by their ever-increasing computational demands and the need for enhanced performance. In this work, we introduce Liger-Kernel, an…

Machine Learning · Computer Science 2025-01-27 Pin-Lun Hsu , Yun Dai , Vignesh Kothapalli , Qingquan Song , Shao Tang , Siyu Zhu , Steven Shimizu , Shivam Sahni , Haowen Ning , Yanning Chen

Deployment complexity and specialized hardware requirements hinder the adoption of deep learning models in neuroimaging. We present MindGrab, a lightweight, fully convolutional model for volumetric skull stripping across all imaging…

Image and Video Processing · Electrical Eng. & Systems 2026-01-30 Armina Fani , Mike Doan , Isabelle Le , Alex Fedorov , Malte Hoffmann , Chris Rorden , Sergey Plis

We propose Spectral Complex Autoencoder Pruning (SCAP), a reconstruction-based criterion that measures functional redundancy at the level of individual output channels. For each convolutional layer, we construct a complex interaction field…

Computer Vision and Pattern Recognition · Computer Science 2026-01-15 Wei Liu , Xing Deng , Haijian Shao , Yingtao Jiang

Triton, a high-level Python-like language designed for building efficient GPU kernels, is widely adopted in deep learning frameworks due to its portability, flexibility, and accessibility. However, programming and parallel optimization…

Computation and Language · Computer Science 2025-02-21 Jianling Li , Shangzhan Li , Zhenye Gao , Qi Shi , Yuxuan Li , Zefan Wang , Jiacheng Huang , Haojie Wang , Jianrong Wang , Xu Han , Zhiyuan Liu , Maosong Sun

Current popular methods for Magnetic Resonance Fingerprint (MRF) recovery are bottlenecked by the heavy computations of a matched-filtering step due to the growing size and complexity of the fingerprint dictionaries in multi-parametric…

Computer Vision and Pattern Recognition · Computer Science 2018-10-05 Mohammad Golbabaee , Zhouye Chen , Yves Wiaux , Mike Davies

Developing efficient GPU kernels is essential for scaling modern AI systems, yet it remains a complex task due to intricate hardware architectures and the need for specialized optimization expertise. Although Large Language Models (LLMs)…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-02-12 Ali Tehrani , Yahya Emara , Essam Wissam , Wojciech Paluch , Waleed Atallah , Łukasz Dudziak , Mohamed S. Abdelfattah

Understanding how developers interact with AI coding assistants requires more than chat logs or git histories in isolation; it requires reconstructing the full context: which prompt led to which edit, what the developer tried and discarded,…

Software Engineering · Computer Science 2026-05-05 Keyu He , Qianou Ma , Valerie Chen , Wayne Chi , Tongshuang Wu

Retrieval-Augmented Generation (RAG) systems suffer from severe time-to-first-token (TTFT) bottlenecks due to long input sequences. Existing KV cache reuse methods face a fundamental trade-off: prefix caching requires identical prefixes…

Machine Learning · Computer Science 2026-05-22 Bin Yang , Qiuyu Leng , Jun Zeng , Zhenhua Wu

As LLMs grow in complexity, achieving state-of-the-art performance requires tight co-design across algorithms, software, and hardware. Today's reliance on a single dominant platform limits portability, creates vendor lock-in, and raises…

Hardware Architecture · Computer Science 2025-07-18 Burkhard Ringlein , Thomas Parnell , Radu Stoica

In the era of LLMs, dense operations such as GEMM and MHA are critical components. These operations are well-suited for parallel execution using a tilebased approach. While traditional GPU programming often relies on low level interfaces…

Computation and Language · Computer Science 2025-03-27 Dewei Wang , Wei Zhu , Liyang Ling , Ettore Tiotto , Quintin Wang , Whitney Tsang , Julian Opperman , Jacky Deng