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Large language models (LLMs) in biomedicine face a fundamental conflict between static parameter knowledge and the dynamic nature of clinical evidence. Retrieval-Augmented Generation (RAG) addresses this by grounding generation in external…

Other Quantitative Biology · Quantitative Biology 2025-12-19 Jiawei He , Boya Zhang , Hossein Rouhizadeh , Yingjian Chen , Rui Yang , Jin Lu , Xudong Chen , Nan Liu , Douglas Teodoro

Question answering systems (QA) utilizing Large Language Models (LLMs) heavily depend on the retrieval component to provide them with domain-specific information and reduce the risk of generating inaccurate responses or hallucinations.…

Computation and Language · Computer Science 2024-06-11 Ashkan Alinejad , Krtin Kumar , Ali Vahdat

Retrieval-Augmented Generation (RAG) enhances Large Language Model (LLM) output by providing prior knowledge as context to input. This is beneficial for knowledge-intensive and expert reliant tasks, including legal question-answering, which…

Retrieval Augmented Generation (RAG) frameworks have shown significant promise in leveraging external knowledge to enhance the performance of large language models (LLMs). However, conventional RAG methods often retrieve documents based…

Computation and Language · Computer Science 2025-04-02 Pouya Pezeshkpour , Estevam Hruschka

This paper presents an experience report on the development of Retrieval Augmented Generation (RAG) systems using PDF documents as the primary data source. The RAG architecture combines generative capabilities of Large Language Models…

Software Engineering · Computer Science 2024-10-22 Ayman Asad Khan , Md Toufique Hasan , Kai Kristian Kemell , Jussi Rasku , Pekka Abrahamsson

Large language models (LLMs) have achieved impressive performance but face high computational costs and latency, limiting their deployment in resource-constrained settings. In contrast, small-scale LLMs (SLMs) are more efficient yet…

Computation and Language · Computer Science 2025-02-18 Tianci Liu , Haoxiang Jiang , Tianze Wang , Ran Xu , Yue Yu , Linjun Zhang , Tuo Zhao , Haoyu Wang

The increasing use of large language models (LLMs) in causal discovery as a substitute for human domain experts highlights the need for optimal model selection. This paper presents the first hallucination survey of popular LLMs for causal…

Computation and Language · Computer Science 2024-11-21 Grace Sng , Yanming Zhang , Klaus Mueller

Large language models (LLMs) often struggle with knowledge intensive NLP tasks, such as answering "Who won the latest World Cup?" because the knowledge they learn during training may be insufficient or outdated. Conditioning generation on…

Computation and Language · Computer Science 2025-03-04 Matthew Finlayson , Ilia Kulikov , Daniel M. Bikel , Barlas Oguz , Xilun Chen , Aasish Pappu

Retrieval-augmented generation (RAG) is considered to be a promising approach to alleviate the hallucination issue of large language models (LLMs), and it has received widespread attention from researchers recently. Due to the limitation in…

Information Retrieval · Computer Science 2024-06-11 Hengran Zhang , Ruqing Zhang , Jiafeng Guo , Maarten de Rijke , Yixing Fan , Xueqi Cheng

Retrieval-Augmented Generation (RAG) has emerged as a critical technique for enhancing large language model (LLM) capabilities. However, practitioners face significant challenges when making RAG deployment decisions. While existing research…

Software Engineering · Computer Science 2025-07-22 Shengming Zhao , Yuchen Shao , Yuheng Huang , Jiayang Song , Zhijie Wang , Chengcheng Wan , Lei Ma

Large Language Models (LLMs) have been integrated into recommendation systems to enhance user behavior comprehension. The Retrieval Augmented Generation (RAG) technique is further incorporated into these systems to retrieve more relevant…

Information Retrieval · Computer Science 2025-02-12 Jian Xu , Sichun Luo , Xiangyu Chen , Haoming Huang , Hanxu Hou , Linqi Song

Despite recent advances, Large Language Models (LLMs) still generate vulnerable code. Retrieval-Augmented Generation (RAG) has the potential to enhance LLMs for secure code generation by incorporating external security knowledge. However,…

Cryptography and Security · Computer Science 2026-03-17 Jiahao Shi , Tianyi Zhang

Retrieval-augmented generation (RAG) utilizes retrieved texts to enhance large language models (LLMs). Studies show that while RAG provides valuable external information (benefit), it may also mislead LLMs (detriment) with noisy or…

Computation and Language · Computer Science 2025-03-03 Shicheng Xu , Liang Pang , Huawei Shen , Xueqi Cheng

Purpose: Large Language Models (LLMs) hold significant promise for medical applications. Retrieval Augmented Generation (RAG) emerges as a promising approach for customizing domain knowledge in LLMs. This case study presents the development…

Retrieval-augmented generation (RAG) improves large language models (LLMs) by using external knowledge to guide response generation, reducing hallucinations. However, RAG, particularly multi-modal RAG, can introduce new hallucination…

Machine Learning · Computer Science 2025-01-08 Matin Mortaheb , Mohammad A. Amir Khojastepour , Srimat T. Chakradhar , Sennur Ulukus

Existing Retrieval-Augmented Generation (RAG) systems face challenges in enterprise settings due to limited retrieval scope and data security risks. When relevant internal documents are unavailable, the system struggles to generate accurate…

Computation and Language · Computer Science 2025-07-18 Grace Byun , Shinsun Lee , Nayoung Choi , Jinho D. Choi

Retrieval-Augmented Generation (RAG) systems enhance large language models (LLMs) by integrating external knowledge, making them adaptable and cost-effective for various applications. However, the growing reliance on these systems also…

Cryptography and Security · Computer Science 2024-10-31 Yucheng Zhang , Qinfeng Li , Tianyu Du , Xuhong Zhang , Xinkui Zhao , Zhengwen Feng , Jianwei Yin

Retrieval-Augmented Generation (RAG) enhances large language models (LLMs) by integrating their parametric knowledge with external retrieved content. However, knowledge conflicts caused by internal inconsistencies or noisy retrieved content…

Computation and Language · Computer Science 2025-07-03 Juan Chen , Baolong Bi , Wei Zhang , Jingyan Sui , Xiaofei Zhu , Yuanzhuo Wang , Lingrui Mei , Shenghua Liu

While Retrieval-Augmented Generation (RAG) has been swiftly adopted in scientific and clinical QA systems, a comprehensive evaluation benchmark in the medical domain is lacking. To address this gap, we introduce the Medical…

Computation and Language · Computer Science 2026-02-12 Liz Li , Wei Zhu

Large Vision-Language Models (LVLMs) have made remarkable strides in multimodal tasks such as visual question answering, visual grounding, and complex reasoning. However, they remain limited by static training data, susceptibility to…

Artificial Intelligence · Computer Science 2025-08-27 Chan-Wei Hu , Yueqi Wang , Shuo Xing , Chia-Ju Chen , Suofei Feng , Ryan Rossi , Zhengzhong Tu