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Epistasis describes the phenomenon that mutations at different loci do not have independent effects with regard to certain phenotypes. Understanding the global epistatic landscape is vital for many genetic and evolutionary theories. Current…

Molecular Networks · Quantitative Biology 2015-02-11 Brandon Barker , Lin Xu , Zhenglong Gu

Energy landscape analysis is a data-driven method to analyze multidimensional time series, including functional magnetic resonance imaging (fMRI) data. It has been shown to be a useful characterization of fMRI data in health and disease. It…

Neurons and Cognition · Quantitative Biology 2024-08-21 Pitambar Khanra , Johan Nakuci , Sarah Muldoon , Takamitsu Watanabe , Naoki Masuda

The advent of computational statistical disciplines, such as machine learning, is leading to a paradigm shift in the way we conceive the design of new compounds. Today computational science does not only provide a sound understanding of…

Materials Science · Physics 2019-11-07 Alessandro Lunghi , Stefano Sanvito

Computation, mechanics and materials merge in biological systems, which can continually self-optimize through internal adaptivity across length scales, from cytoplasm and biofilms to animal herds. Recent interest in such material-based…

Soft Condensed Matter · Physics 2023-04-19 Vishal P. Patil , Ian Ho , Manu Prakash

For decades, it was unknown how electron bifurcating systems in Nature prevented energy-wasting short-circuiting reactions that have large driving forces, so synthetic electron bifurcating molecular machines could not be designed and built.…

Biological Physics · Physics 2020-09-09 Jonathon L. Yuly , Peng Zhang , Carolyn E. Lubner , John W. Peters , David N. Beratan

External fields can decidedly alter the free energy landscape of soft materials and can be exploited as a powerful tool for the assembly of targeted nanostructures and colloidal materials. Here, we use computer simulations to demonstrate…

Soft Condensed Matter · Physics 2019-02-08 Ahmad K. Omar , Yanze Wu , Zhen-Gang Wang , John F. Brady

Autonomous robots are increasingly deployed for long-term information-gathering tasks, which pose two key challenges: planning informative trajectories in environments that evolve across space and time, and ensuring persistent operation…

Robotics · Computer Science 2025-05-20 Kaleb Ben Naveed , Devansh R. Agrawal , Rahul Kumar , Dimitra Panagou

Driverless vehicles are complex systems operating in constantly changing environments. Automated driving is achieved by controlling the coupled longitudinal and lateral vehicle dynamics. Model predictive control is one of the most promising…

Optimization and Control · Mathematics 2025-09-25 Yassine Kebbati , Naima Ait-Oufroukh , Vicenç Puig , Vincent Vigneron , Dalil Ichalal

Motivated by the benefits of multi-energy integration, this paper establishes a bi-level two-stage framework based on transactive control, in order to achieve optimal energy provision among interconnected multi-energy systems (MESs). At the…

Optimization and Control · Mathematics 2019-10-23 Yizhi Cheng , Peichao Zhang , Xuezhi Liu

The design of self-sustainable base station (BS) deployments is addressed in this paper: BSs have energy harvesting and storage capabilities, they can use ambient energy to serve the local traffic or store it for later use. A dedicated…

Networking and Internet Architecture · Computer Science 2018-03-19 Angel Fernandez Gambin , Maria Scalabrin , Michele Rossi

Self-assembly plays an essential role in many natural processes, involving the formation and evolution of living or non-living structures, and shows potential applications in many emerging domains. In existing research and practice, there…

Multiagent Systems · Computer Science 2021-02-24 Wenjie Chu , Wei Zhang , Haiyan Zhao , Zhi Jin , Hong Mei

In physical networks trained using supervised learning, physical parameters are adjusted to produce desired responses to inputs. An example is electrical contrastive local learning networks of nodes connected by edges that are resistors…

Disordered Systems and Neural Networks · Physics 2024-12-30 Marcel Guzman , Felipe Martins , Menachem Stern , Andrea J. Liu

We describe a numerical study of the potential energy landscape for the two-dimensional XY model (with no disorder), considering up to 100 spins and CPU and GPU implementations of local optimization, focusing on minima and saddles of index…

Statistical Mechanics · Physics 2013-11-27 Dhagash Mehta , Ciaran Hughes , Mario Schröck , David J. Wales

Non-equilibrium systems display memory, a dependence not merely on their present environment but on previously applied fields. Multistable systems such as spin glasses, martensites and granular matter have exponentially many microstates…

Statistical Mechanics · Physics 2026-05-25 Nathaniel Croce , Hossein Salahshoor , D. Zeb Rocklin

The growing prevalence of extreme weather events driven by climate change poses significant challenges to power system resilience. Infrastructure damage and prolonged power outages highlight the urgent need for effective grid-hardening…

Systems and Control · Electrical Eng. & Systems 2026-01-30 Sifat Chowdhury , Yihsu Chen , Yu Zhang

Robotic manipulation in dynamic environments often requires seamless transitions between different grasp types to maintain stability and efficiency. However, achieving smooth and adaptive grasp transitions remains a challenge, particularly…

Robotics · Computer Science 2025-09-24 Kuanqi Cai , Chunfeng Wang , Zeqi Li , Haowen Yao , Weinan Chen , Luis Figueredo , Aude Billard , Arash Ajoudani

We propose a new driving scheme, when different parts of a system are driven with different, generally incommensurate, frequencies. Such driving provides a flexible handle to control various properties of the system and to obtain new types…

Optics · Physics 2018-03-01 Huanan Li , Tsampikos Kottos , Boris Shapiro

The sustainability of Machine Learning-Enabled Systems (MLS), particularly with regard to energy efficiency, is an important challenge in their development and deployment. Self-adaptation techniques, recognized for their potential in energy…

Software Engineering · Computer Science 2024-04-18 Meghana Tedla , Shubham Kulkarni , Karthik Vaidhyanathan

Active materials are capable of converting free energy into mechanical work to produce autonomous motion, and exhibit striking collective dynamics that biology relies on for essential functions. Controlling those dynamics and transport in…

The presence of multiple stable states and associated nonlinear phenomena, such as hysteresis, in multistable mechanical metamaterials enables frequency-independent energy harvesting and shock absorption. This study focuses on shock…

Pattern Formation and Solitons · Physics 2026-03-16 Sneha Srikanth , Andres F. Arrieta