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The advancement of large language models (LLMs) for real-world applications hinges critically on enhancing their reasoning capabilities. In this work, we explore the reasoning abilities of large language models (LLMs) through their…

Artificial Intelligence · Computer Science 2024-07-04 Romain Cosentino , Sarath Shekkizhar

The releases of powerful open-weight large language models (LLMs) are often not accompanied by access to their full training data. Existing interpretability methods, particularly those based on activations, often require or assume…

Machine Learning · Computer Science 2026-04-22 Ziqian Zhong , Aditi Raghunathan

Predicting phenotypes with complex genetic bases based on a small, interpretable set of variant features remains a challenging task. Conventionally, data-driven approaches are utilized for this task, yet the high dimensional nature of…

Machine Learning · Computer Science 2025-04-17 Joseph Lee , Shu Yang , Jae Young Baik , Xiaoxi Liu , Zhen Tan , Dawei Li , Zixuan Wen , Bojian Hou , Duy Duong-Tran , Tianlong Chen , Li Shen

Post-training data plays a pivotal role in shaping the capabilities of Large Language Models (LLMs), yet datasets are often treated as isolated artifacts, overlooking the systemic connections that underlie their evolution. To disentangle…

Artificial Intelligence · Computer Science 2026-04-14 Yu Li , Xiaoran Shang , Qizhi Pei , Yun Zhu , Xin Gao , Honglin Lin , Zhanping Zhong , Zhuoshi Pan , Zheng Liu , Xiaoyang Wang , Conghui He , Dahua Lin , Feng Zhao , Lijun Wu

Large language models (LLMs) are having transformative impacts across a wide range of scientific fields, particularly in the biomedical sciences. Just as the goal of Natural Language Processing is to understand sequences of words, a major…

Genomics · Quantitative Biology 2024-09-24 Gonzalo Benegas , Chengzhong Ye , Carlos Albors , Jianan Canal Li , Yun S. Song

Large language models (LLMs) have significantly advanced in various fields and intelligent agent applications. However, current LLMs that learn from human or external model supervision are costly and may face performance ceilings as task…

Computation and Language · Computer Science 2024-06-04 Zhengwei Tao , Ting-En Lin , Xiancai Chen , Hangyu Li , Yuchuan Wu , Yongbin Li , Zhi Jin , Fei Huang , Dacheng Tao , Jingren Zhou

Recent successes in language modeling, notably with deep learning methods, coincide with a shift from probabilistic to weighted representations. We raise here the question of the importance of this evolution, in the light of the practical…

Other Quantitative Biology · Quantitative Biology 2019-08-05 François Coste

Ontology, and more broadly, Knowledge Graph Matching is a challenging task in which expressiveness has not been fully addressed. Despite the increasing use of embeddings and language models for this task, approaches for generating…

Computation and Language · Computer Science 2025-02-20 Guilherme Sousa , Rinaldo Lima , Cassia Trojahn

Large language models (LLMs) are transforming cellular biology by enabling the development of "virtual cells"--computational systems that represent, predict, and reason about cellular states and behaviors. This work provides a comprehensive…

Computation and Language · Computer Science 2025-10-10 Krinos Li , Xianglu Xiao , Shenglong Deng , Lucas He , Zijun Zhong , Yuanjie Zou , Zhonghao Zhan , Zheng Hui , Weiye Bao , Guang Yang

We propose a model for the evolutionary ecology of words as one attempt to extend evolutionary game theory and agent-based models by utilizing the rich linguistic expressions of Large Language Models (LLMs). Our model enables the emergence…

Populations and Evolution · Quantitative Biology 2025-05-12 Reiji Suzuki , Takaya Arita

This critical review provides an in-depth analysis of Large Language Models (LLMs), encompassing their foundational principles, diverse applications, and advanced training methodologies. We critically examine the evolution from Recurrent…

Artificial Intelligence · Computer Science 2025-09-29 Milad Moradi , Ke Yan , David Colwell , Matthias Samwald , Rhona Asgari

Fine-tuning pre-trained language models, particularly large language models, demands extensive computing resources and can result in varying performance outcomes across different domains and datasets. This paper examines the approach of…

Computation and Language · Computer Science 2024-06-19 Guodong Du , Jing Li , Hanting Liu , Runhua Jiang , Shuyang Yu , Yifei Guo , Sim Kuan Goh , Ho-Kin Tang

This paper explores the seamless integration of Generative AI (GenAI) and Evolutionary Algorithms (EAs) within the domain of large-scale multi-objective optimization. Focusing on the transformative role of Large Language Models (LLMs), our…

Neural and Evolutionary Computing · Computer Science 2024-05-14 Gaurav Singh , Kavitesh Kumar Bali

In the realm of machine learning, traditional model development and automated approaches like AutoML typically rely on layers of abstraction, such as tree-based or Cartesian genetic programming. Our study introduces "Guided Evolution" (GE),…

Neural and Evolutionary Computing · Computer Science 2024-07-18 Clint Morris , Michael Jurado , Jason Zutty

Large Language Models (LLMs) have demonstrated great promise in generating code, especially when used inside an evolutionary computation framework to iteratively optimize the generated algorithms. However, in some cases they fail to…

Neural and Evolutionary Computing · Computer Science 2025-03-24 Niki van Stein , Anna V. Kononova , Lars Kotthoff , Thomas Bäck

Hyperparameter optimization is a crucial problem in Evolutionary Computation. In fact, the values of the hyperparameters directly impact the trajectory taken by the optimization process, and their choice requires extensive reasoning by…

Neural and Evolutionary Computing · Computer Science 2024-08-06 Leonardo Lucio Custode , Fabio Caraffini , Anil Yaman , Giovanni Iacca

While Large Language Models (LLMs) have demonstrated exceptional multitasking abilities, fine-tuning these models on downstream, domain-specific datasets is often necessary to yield superior performance on test sets compared to their…

Computation and Language · Computer Science 2024-03-15 Haoran Yang , Yumeng Zhang , Jiaqi Xu , Hongyuan Lu , Pheng Ann Heng , Wai Lam

Integrating Large Language Models (LLMs) and Evolutionary Computation (EC) represents a promising avenue for advancing artificial intelligence by combining powerful natural language understanding with optimization and search capabilities.…

Neural and Evolutionary Computing · Computer Science 2025-05-22 Dikshit Chauhan , Bapi Dutta , Indu Bala , Niki van Stein , Thomas Bäck , Anupam Yadav

Large Language Models (LLMs) possess outstanding capabilities in addressing various natural language processing (NLP) tasks. However, the sheer size of these models poses challenges in terms of storage, training and inference due to the…

Computation and Language · Computer Science 2025-04-18 Shuzhou Yuan , Ercong Nie , Bolei Ma , Michael Färber

Large Language Models (LLMs), such as ChatGPT, have taken the world by storm and have passed certain forms of the Turing test. However, LLMs are not limited to human language and analyze sequential data, such as DNA, protein, and gene…

Genomics · Quantitative Biology 2024-01-08 Hilbert Yuen In Lam , Xing Er Ong , Marek Mutwil