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Related papers: Parameter estimation for evaporation-driven tear f…

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Evaporation profiles have a strong effect on tear film thinning and breakup (TBU), a key factor in dry eye disease (DED). In experiments, TBU is typically seen to occur in patterns that locally can be circular (spot), linear (streak), or…

Numerical Analysis · Mathematics 2024-08-30 Qinying Chen , Tobin A. Driscoll , Richard J. Braun

The contribution of different physical effects to tear breakup (TBU) in subjects with no self-reported history of dry eye are quantified. An automated system using a convolutional neural network is deployed on fluorescence (FL) imaging…

Etiologies of tear breakup include evaporation-driven, divergent flow-driven, and a combination of these two. A mathematical model incorporating evaporation and lipid-driven tangential flow is fit to fluorescence imaging data. The…

Purpose: To determine whether evaporation, tangential flow, or a combination of the two cause tear film breakup in a variety of instances; to estimate related breakup parameters that cannot be measured in breakup during subject trials; and…

Fluid Dynamics · Physics 2022-11-10 Rayanne A. Luke , Richard J. Braun , Carolyn G. Begley

Fluorescein is perhaps the most commonly used substance to visualize tear film thickness and dynamics; better understanding of this process aids understanding of dry eye syndrome which afflicts millions of people. We study a mathematical…

Quantitative Methods · Quantitative Biology 2016-11-01 Longfei Li , R. J. Braun , W. D. Henshaw , P. E. King-Smith

The human tear film (TF) is thin multilayer fluid film that is critical for clear vision and ocular surface health. Its dynamics are strongly affected by a floating lipid layer and, in health, that layer slows evaporation and helps create a…

Fluid Dynamics · Physics 2024-04-23 M. J. Taranchuk , R. J. Braun

Tear film (TF) breakup is a key driver of understanding dry eye disease, yet estimating TF thickness and osmolarity from fluorescence (FL) imaging typically requires solving computationally expensive inverse problems. We propose an operator…

Numerical Analysis · Mathematics 2026-01-14 Qinying Chen , Arnab Roy , Tobin A. Driscoll

Motivated by a model proposed by Peng et al. [Advances in Coll. and Interf. Sci. 206 (2014)] for break-up of tear films on human eyes, we study the dynamics of a generalized thin film model. The governing equations form a fourth-order…

Analysis of PDEs · Mathematics 2022-11-08 Yuan Gao , Hangjie Ji , Jian-Guo Liu , Thomas P. Witelski

Tear film break-up (TFBU) analysis is critical for diagnosing dry eye syndrome, but automated TFBU segmentation remains challenging due to the lack of annotated datasets and integrated solutions. This paper introduces the Tear Film…

Computer Vision and Pattern Recognition · Computer Science 2025-10-09 Guangrong Wan , Jun liu , Qiyang Zhou , Tang tang , Lianghao Shi , Wenjun Luo , TingTing Xu

Dry Eye Disease (DED) is one of the most common ocular diseases: over five percent of US adults suffer from DED. Tear film instability is a known factor for DED, and is thought to be regulated in large part by the thin lipid layer that…

Computer Vision and Pattern Recognition · Computer Science 2022-12-08 Tejasvi Kothapalli , Charlie Shou , Jennifer Ding , Jiayun Wang , Andrew D. Graham , Tatyana Svitova , Stella X. Yu , Meng C. Lin

One of the main roles of the lipid layer (LL) of the tear film (TF) is to help prevent evaporation of the aqueous layer (AL). The LL thickness, composition, and structure all contribute to its barrier function. It is believed that the lipid…

Fluid Dynamics · Physics 2024-04-29 M. J. Taranchuk , R. J. Braun

During the upstroke of a normal eye blink, the upper lid moves and paints a thin tear film over the exposed corneal and conjunctival surfaces. This thin tear film may be modeled by a nonlinear fourth-order PDE derived from lubrication…

Numerical Analysis · Mathematics 2017-04-07 Tobin A. Driscoll , Richard J. Braun , Joseph K. Brosch

Thin film interferometry is a powerful technique for non-invasively measuring liquid film thickness with applications in ophthalmology, but its clinical translation is hindered by the challenges in reconstructing thickness profiles from…

Computer Vision and Pattern Recognition · Computer Science 2025-10-30 Gautam A. Viruthagiri , Arnuv Tandon , Gerald G. Fuller , Vinny Chandran Suja

The continuing development of evaporative lithography is important for many areas such as the creation of photonic crystals for optronics and microelectronics, the development of biosensors for medical applications and biotechnology, and…

Soft Condensed Matter · Physics 2024-04-04 Konstantin Kolegov

Tear film rupture on the corneal surface plays a critical role in ocular health and visual comfort. Conventional theoretical approaches often idealize the cornea as a perfectly smooth surface, ignoring the surface roughness that are…

Fluid Dynamics · Physics 2026-03-20 Deepak Kumar , S Pushpavanam

Tumble dryers offer a fast and convenient way of drying textiles independent of weather conditions and therefore are frequently used in ordinary households. However, artificial drying of textiles consumes considerable amounts of energy,…

Numerical Analysis · Mathematics 2023-04-10 Sajad Salavatidezfouli , Arash Hajisharifi , Michele Girfoglio , Giovanni Stabile , Gianluigi Rozza

Atmospheric turbulence and aero-optic effects cause phase aberrations in propagating light waves, thereby reducing effectiveness in transmitting and receiving coherent light from an aircraft. Existing optical sensors can measure the…

Signal Processing · Electrical Eng. & Systems 2026-02-12 Jeffrey W. Utley , Gregery T. Buzzard , Charles A. Bouman , Matthew R. Kemnetz

Purpose: To evaluate the efficacy of a recently proposed method for characterizing tear film dynamics using non-invasive high speed videokeratoscopy in assessing the loss of homeostasis of tear film. Methods: Thirty subjects, from a…

Medical Physics · Physics 2019-02-14 Clara Llorens-Quintana , Dorota H. Szczesna-Iskander , D. Robert Iskander

The performance of solution-processed solar cells strongly depends on the geometrical structure and roughness of the photovoltaic layers formed during film drying. During the drying process, the interplay of crystallization and…

A theoretical framework is established to model the evaporation from continuously fed droplets, promising tools in the thermal management of high heat flux electronics. Using the framework, a comprehensive model is developed for a…

Applied Physics · Physics 2020-08-25 Yigit Akkus , Barbaros Cetin , Zafer Dursunkaya
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