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Artificial intelligence in healthcare requires models that are accurate and interpretable. We advance mechanistic interpretability in medical vision by applying Medical Sparse Autoencoders (MedSAEs) to the latent space of MedCLIP, a…

Artificial Intelligence · Computer Science 2026-05-25 Riccardo Renzulli , Colas Lepoutre , Enrico Cassano , Marco Grangetto

Latent diffusion models have established a new state-of-the-art in high-resolution visual generation. Integrating Vision Foundation Model priors improves generative efficiency, yet existing latent designs remain largely heuristic. These…

Computer Vision and Pattern Recognition · Computer Science 2026-03-13 Hangyu Liu , Jianyong Wang , Yutao Sun

Sparse Autoencoder (SAE) has emerged as a powerful tool for mechanistic interpretability of large language models. Recent works apply SAE to protein language models (PLMs), aiming to extract and analyze biologically meaningful features from…

Quantitative Methods · Quantitative Biology 2026-01-21 Xiangyu Liu , Haodi Lei , Yi Liu , Yang Liu , Wei Hu

Sparse autoencoders (SAEs) have recently emerged as a powerful tool for interpreting the internal representations of large language models (LLMs), revealing latent latent features with semantical meaning. This interpretability has also…

Other Quantitative Biology · Quantitative Biology 2025-07-11 Haoxiang Guan , Jiyan He , Jie Zhang

The application of machine learning algorithms to the diagnosis and analysis of Alzheimer's disease (AD) from multimodal neuroimaging data is a current research hotspot. It remains a formidable challenge to learn brain region information…

Image and Video Processing · Electrical Eng. & Systems 2022-08-11 Yongcheng Zong , Changhong Jing , Qiankun Zuo

This study presents Latent Diffusion Autoencoder (LDAE), a novel encoder-decoder diffusion-based framework for efficient and meaningful unsupervised learning in medical imaging, focusing on Alzheimer disease (AD) using brain MR from the…

Computer Vision and Pattern Recognition · Computer Science 2026-01-12 Gabriele Lozupone , Alessandro Bria , Francesco Fontanella , Frederick J. A. Meijer , Claudio De Stefano , Henkjan Huisman

We present Universal Sparse Autoencoders (USAEs), a framework for uncovering and aligning interpretable concepts spanning multiple pretrained deep neural networks. Unlike existing concept-based interpretability methods, which focus on a…

Computer Vision and Pattern Recognition · Computer Science 2026-03-20 Harrish Thasarathan , Julian Forsyth , Thomas Fel , Matthew Kowal , Konstantinos G. Derpanis

The classical sparse coding model represents visual stimuli as a linear combination of a handful of learned basis functions that are Gabor-like when trained on natural image data. However, the Gabor-like filters learned by classical sparse…

Artificial Intelligence · Computer Science 2023-02-23 Jonathan Huml , Abiy Tasissa , Demba Ba

Sparse Autoencoders (SAEs) provide potentials for uncovering structured, human-interpretable representations in Large Language Models (LLMs), making them a crucial tool for transparent and controllable AI systems. We systematically analyze…

Machine Learning · Computer Science 2026-02-03 Jack Gallifant , Shan Chen , Kuleen Sasse , Hugo Aerts , Thomas Hartvigsen , Danielle S. Bitterman

Autoencoder (AE) is a neural network (NN) architecture that is trained to reconstruct an input at its output. By measuring the reconstruction errors of new input samples, AE can detect anomalous samples deviated from the trained data…

Machine Learning · Computer Science 2023-02-16 Jinho Choi , Jihong Park , Abhinav Japesh , Adarsh

Intermediate layers of large language models (LLMs) best predict human brain responses to language, one of the most robust findings in computational neurolinguistics, yet why remains mechanistically unexplained. We address this gap by…

Computation and Language · Computer Science 2026-05-25 Dongxin Guo , Jikun Wu , Siu Ming Yiu

Accurate automated segmentation of tibial plateau fractures (TPF) from computed tomography (CT) requires large amounts of annotated data to train deep learning models, but obtaining such annotations presents unique challenges. The process…

Image and Video Processing · Electrical Eng. & Systems 2025-04-10 Peiyan Yue , Die Cai , Chu Guo , Mengxing Liu , Jun Xia , Yi Wang

A recent line of work has shown promise in using sparse autoencoders (SAEs) to uncover interpretable features in neural network representations. However, the simple linear-nonlinear encoding mechanism in SAEs limits their ability to perform…

Machine Learning · Computer Science 2025-01-31 Charles O'Neill , Alim Gumran , David Klindt

Decomposing model activations into interpretable components is a key open problem in mechanistic interpretability. Sparse autoencoders (SAEs) are a popular method for decomposing the internal activations of trained transformers into sparse,…

Machine Learning · Computer Science 2024-06-26 Connor Kissane , Robert Krzyzanowski , Joseph Isaac Bloom , Arthur Conmy , Neel Nanda

Sparse autoencoders (SAEs) are used to decompose neural network activations into sparsely activating features, but many SAE features are only interpretable at high activation strengths. To address this issue we propose to use binary sparse…

Machine Learning · Computer Science 2025-10-01 Lucia Quirke , Stepan Shabalin , Nora Belrose

Sparse autoencoders (SAEs) model the activations of a neural network as linear combinations of sparsely occurring directions of variation (latents). The ability of SAEs to reconstruct activations follows scaling laws w.r.t. the number of…

Machine Learning · Computer Science 2025-09-05 Eric J. Michaud , Liv Gorton , Tom McGrath

Sparse autoencoders (SAEs) are widely used in mechanistic interpretability research for large language models; however, the state-of-the-art method of using $k$-sparse autoencoders lacks a theoretical grounding for selecting the…

Machine Learning · Computer Science 2025-08-11 Sewoong Lee , Adam Davies , Marc E. Canby , Julia Hockenmaier

Sparse autoencoders (SAEs) have become a central tool for interpreting language models. However, two key SAE analyses that remain difficult to scale are (1) matching semantically similar features across multi-layers and (2) compressing…

Machine Learning · Computer Science 2026-05-28 Tue M. Cao , Nguyen Do , My T. Thai

In this paper, we introduce a novel normative modeling approach that incorporates focal loss and adversarial autoencoders (FAAE) for Alzheimer's Disease (AD) diagnosis and biomarker identification. Our method is an end-to-end approach that…

Image and Video Processing · Electrical Eng. & Systems 2024-11-19 Songlin Zhao , Rong Zhou , Yu Zhang , Yong Chen , Lifang He

Sparse autoencoders (SAEs) are an unsupervised method for learning a sparse decomposition of a neural network's latent representations into seemingly interpretable features. Despite recent excitement about their potential, research…