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RNA sequencing (RNA-seq) is the conventional genome-scale approach used to capture the expression levels of all detectable genes in a biological sample. This is now regularly used for population-based studies designed to identify genetic…

Genomics · Quantitative Biology 2026-05-25 Christopher Thron , Farhad Jafari

Large Language Models (LLMs) deployed in high-stakes applications must simultaneously manage multiple risks, yet existing defenses are almost exclusively evaluated in isolation under a one-shot deployment assumption. In practice, providers…

Cryptography and Security · Computer Science 2026-05-15 Xiangtao Meng , Wenyu Chen , Chuanchao Zang , Xinyu Gao , Jianing Wang , Li Wang , Zheng Li , Shanqing Guo

Training data leakage from Large Language Models (LLMs) raises serious concerns related to privacy, security, and copyright compliance. A central challenge in assessing this risk is distinguishing genuine memorization of training data from…

Machine Learning · Computer Science 2026-02-24 Trishita Tiwari , Ari Trachtenberg , G. Edward Suh

Retrieval-Augmented Generation (RAG) has become a standard approach for improving the reliability of large language models (LLMs). Prior work demonstrates the vulnerability of RAG systems by misleading them into generating attacker-chosen…

Cryptography and Security · Computer Science 2025-08-28 Yanbo Dai , Zhenlan Ji , Zongjie Li , Kuan Li , Shuai Wang

Retrieval-Augmented Generation (RAG) has emerged as a foundational paradigm for grounding large language models in external knowledge. While adaptive retrieval mechanisms have improved retrieval efficiency, existing approaches treat…

Computation and Language · Computer Science 2026-04-20 Kai Wei , Raymond Li , Xi Zhu , Zhaoqian Xue , Jiaojiao Han , Jingcheng Niu , Fan Yang

Geometric morphometrics (GMM) is widely used to quantify shape variation, more recently serving as input for machine learning (ML) analyses. Standard practice aligns all specimens via Generalized Procrustes Analysis (GPA) prior to splitting…

Computer Vision and Pattern Recognition · Computer Science 2026-01-27 Lloyd Austin Courtenay

Medical image segmentation is a crucial task in medical image analysis, but it can be very challenging especially when there are less labeled data but with large unlabeled data. Contrastive learning has proven to be effective for medical…

Computer Vision and Pattern Recognition · Computer Science 2025-02-11 Shihuan He , Zhihui Lai , Ruxin Wang , Heng Kong

Generative adversarial network (GAN) continues to be a popular research direction due to its high generation quality. It is observed that many state-of-the-art GANs generate samples that are more similar to the training set than a holdout…

Machine Learning · Computer Science 2022-10-25 Andrew Bai , Cho-Jui Hsieh , Wendy Kan , Hsuan-Tien Lin

Pseudo-random number generators (PRNG) are a fundamental element of many security algorithms. We introduce a novel approach to their implementation, by proposing the use of generative adversarial networks (GAN) to train a neural network to…

Machine Learning · Computer Science 2018-10-02 Marcello De Bernardi , MHR Khouzani , Pasquale Malacaria

Mechanistic interpretability aims to understand neural networks by identifying which learned features mediate specific behaviors. Attribution graphs reveal these feature pathways, but interpreting them requires extensive manual analysis --…

Computation and Language · Computer Science 2025-11-11 Giuseppe Birardi

Large Language Models (LLMs) have become integral to automated code analysis, enabling tasks such as vulnerability detection and code comprehension. However, their integration introduces novel attack surfaces. In this paper, we identify and…

Cryptography and Security · Computer Science 2025-07-23 Yue Li , Xiao Li , Hao Wu , Yue Zhang , Fengyuan Xu , Xiuzhen Cheng , Sheng Zhong

Machine Learning, particularly Generative Adversarial Networks (GANs), has revolutionised Super-Resolution (SR). However, generated images often lack physical meaningfulness, which is essential for scientific applications. Our approach,…

Image and Video Processing · Electrical Eng. & Systems 2025-08-13 Md Rakibul Hasan , Pouria Behnoudfar , Dan MacKinlay , Thomas Poulet

Retrieval-Augmented Generation (RAG) systems enhance text generation by incorporating external knowledge but often struggle when retrieving context across different text modalities due to semantic gaps. We introduce a generalized…

Machine Learning · Computer Science 2024-11-01 Arihan Yadav , Alan McMillan

We propose Curved Inference - a geometric Interpretability framework that tracks how the residual stream trajectory of a large language model bends in response to shifts in semantic concern. Across 20 matched prompts spanning emotional,…

Computation and Language · Computer Science 2025-07-30 Rob Manson

Protein language models often take into consideration the alignment between a protein sequence and its textual description. However, they do not take structural information into consideration. Traditional methods treat sequence and…

Machine Learning · Computer Science 2026-03-10 Aditya Ranganath , Hasin Us Sami , Kowshik Thopalli , Bhavya Kailkhura , Wesam Sakla

Side Channel Analysis (SCA) relaxes the black-box assumption of conventional cryptanalysis by incorporating physical measurements acquired during cryptographic operations. Electro-magnetic (EM) emissions of a chip during computations often…

Cryptography and Security · Computer Science 2026-04-28 Elie Bursztein , Michael Gruber , Karel Král , Jean-Michel Picod , Matthias Probst , Georg Sigl

Deep neural networks perform remarkably well on image classification tasks but remain vulnerable to carefully crafted adversarial perturbations. This work revisits linear dimensionality reduction as a simple, data-adapted defense. We…

Machine Learning · Computer Science 2025-10-08 Killian Steunou , Théo Druilhe , Sigurd Saue

Neural representations are not unique objects. Even when two systems realize the same downstream computation, their hidden coordinates may differ by reparameterization. A probe family intended to reveal structure already present in a…

Machine Learning · Computer Science 2026-05-13 Su Hyeong Lee , Risi Kondor

Sparse Principal Component Analysis (sparse PCA) is a fundamental dimension-reduction tool that enhances interpretability in various high-dimensional settings. An important variant of sparse PCA studies the scenario when samples are…

Optimization and Control · Mathematics 2024-11-11 Yuqing He , Guanyi Wang , Yu Yang

In clinical practice, a segmentation network is often required to continually learn on a sequential data stream from multiple sites rather than a consolidated set, due to the storage cost and privacy restriction. However, during the…

Image and Video Processing · Electrical Eng. & Systems 2022-06-28 Jingyang Zhang , Peng Xue , Ran Gu , Yuning Gu , Mianxin Liu , Yongsheng Pan , Zhiming Cui , Jiawei Huang , Lei Ma , Dinggang Shen