Related papers: Protein-Conditioned Multi-Objective Reinforcement …

We introduce RosettaSearch, an inference-time multi-objective optimization approach for backbone conditioned protein sequence design. We use large language models (LLMs) as a generative optimizer within a search algorithm capable of…

This document contains supplementary material for the paper "Multi-objective Reinforcement Learning with Continuous Pareto Frontier Approximation", published at the Twenty-Ninth AAAI Conference on Artificial Intelligence (AAAI-15). The…

Prompt tuning has become a new paradigm for model tuning and it has demonstrated success in natural language pretraining and even vision pretraining. In this work, we explore the transfer of prompt tuning to multimodal pretraining, with a…

Automatic Radiology Report Generation (RRG) is an important topic for alleviating the substantial workload of radiologists. Existing RRG approaches rely on supervised regression based on different architectures or additional knowledge…

This study develops a generalised multi-objective, multi-echelon supply chain optimisation model with non-stationary markets based on a Markov decision process, incorporating economic, environmental, and social considerations. The model is…

Multi-objective combinatorial optimization problems (MOCOPs), one type of complex optimization problems, widely exist in various real applications. Although meta-heuristics have been successfully applied to address MOCOPs, the calculation…

Multi-objective optimization is key to solving many Engineering Design problems, where design parameters are optimized for several performance indicators. However, optimization results are highly dependent on how the designs are…

Aligning large language models to human preferences is inherently multidimensional, yet most pipelines collapse heterogeneous signals into a single optimizeable objective. We seek to answer what it would take to simultaneously align a model…

Training large models ranging from millions to billions of parameters is highly resource-intensive, requiring significant time, compute, and memory. It is observed that most of the learning (higher change in weights) takes place in the…

This paper introduces a new scalable multi-objective deep reinforcement learning (MODRL) framework based on deep Q-networks. We develop a high-performance MODRL framework that supports both single-policy and multi-policy strategies, as well…

Multi-objective reinforcement learning (MORL) is a structured approach for optimizing tasks with multiple objectives. However, it often relies on pre-defined reward functions, which can be hard to design for balancing conflicting goals and…

In the realm of multi-objective alignment for large language models, balancing disparate human preferences often manifests as a zero-sum conflict. Specifically, the intrinsic tension between competing goals dictates that aggressively…

We report a flexible language-model based deep learning strategy, applied here to solve complex forward and inverse problems in protein modeling, based on an attention neural network that integrates transformer and graph convolutional…

Myopic Optimization with Non-myopic Approval (MONA) mitigates multi-step reward hacking by restricting the agent's planning horizon while supplying far-sighted approval as a training signal~\cite{farquhar2025mona}. The original paper…

Recent advances in supervised learning and reinforcement learning have provided new opportunities to apply related methodologies to automated driving. However, there are still challenges to achieve automated driving maneuvers in dynamically…

Fine-tuning large-scale pretrained models has led to tremendous progress in well-studied modalities such as vision and NLP. However, similar gains have not been observed in many other modalities due to a lack of relevant pretrained models.…

The goal of multi-objective reinforcement learning (MORL) is to learn policies that simultaneously optimize multiple competing objectives. In practice, an agent's preferences over the objectives may not be known apriori, and hence, we…

Designing missiles' autopilot controllers has been a complex task, given the extensive flight envelope and the nonlinear flight dynamics. A solution that can excel both in nominal performance and in robustness to uncertainties is still to…

Robots have been successfully used to perform tasks with high precision. In real-world environments with sparse rewards and multiple goals, learning is still a major challenge and Reinforcement Learning (RL) algorithms fail to learn good…

This work presents RNAdiffusion, a latent diffusion model for generating and optimizing discrete RNA sequences of variable lengths. RNA is a key intermediary between DNA and protein, exhibiting high sequence diversity and complex…