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Water plays a fundamental role in the structure and function of proteins and other biomolecules. The thermodynamic profile of water molecules surrounding a protein are critical for ligand binding and recognition. Therefore, identifying the…

Biomolecules · Quantitative Biology 2024-11-26 Florian B. Hinz , Matthew R. Masters , Julia N. Kieu , Amr H. Mahmoud , Markus A. Lill

The thermodynamics and dynamics of supercooled liquids correlate with their elasticity. In particular for covalent networks, the jump of specific heat is small and the liquid is {\it strong} near the threshold valence where the network…

Disordered Systems and Neural Networks · Physics 2015-09-02 Le Yan , Matthieu Wyart

The rapid rise of viscosity or relaxation time upon supercooling is universal hallmark of glassy liquids. The temperature dependence of the viscosity, however, is quite non universal for glassy liquids and is characterized by the system's…

Soft Condensed Matter · Physics 2022-10-12 Indrajit Tah , Sean A. Ridout , Andrea J. Liu

Phases with distinct thermodynamic properties must differ in their underlying distributions of microscopic structures. While ordered phases are readily distinguished by unit cells and space groups, the local structural basis differentiating…

Liquid water is reluctant to lose hydrogen-bond coordination. Here we reveal that it also demands contraction and reorientation of the second molecular shell to compensate for coordination defects. Such molecular principle will be shown to…

Soft Condensed Matter · Physics 2024-08-27 Nicolás A. Loubet , Alejandro R. Verde , Gustavo A. Appignanesi

Machine-learning (ML) has become a key workhorse in molecular simulations. Building an ML model in this context, involves encoding the information of chemical environments using local atomic descriptors. In this work, we focus on the Smooth…

Soft Condensed Matter · Physics 2023-04-21 Edward Danquah Donkor , Alessandro Laio , Ali Hassanali

In the quest to understand how structure and dynamics are connected in glasses, a number of machine learning based methods have been developed that predict dynamics in supercooled liquids. These methods include both increasingly complex…

Soft Condensed Matter · Physics 2022-06-08 Rinske M. Alkemade , Emanuele Boattini , Laura Filion , Frank Smallenburg

In this work, we provide mechanistic insight into the initial stages of formation of ice across the limit of stability of supercooled water. Such an analysis is particularly important since crystal nucleation is not a relevant mechanism…

Statistical Mechanics · Physics 2026-05-26 Ashutosh Srivastava , Pankaj A. Apte

In this study, we demonstrate the generalizability of graph neural networks in predicting the dynamic heterogeneity of model glass-forming liquids across different temperatures. While previous approaches have often been limited to making…

Soft Condensed Matter · Physics 2026-03-17 Hidemasa Bessho , Takeshi Kawasaki , Hayato Shiba

Methanol-water liquid mixtures have been investigated by high-energy synchrotron X-ray and neutron diffraction at low temperatures. We are thus able to report the first complete sets of both X-ray and neutron weighted total scattering…

Unraveling the relation between structural information and the dynamic properties of supercooled liquids is one of the grand challenges of physics. Dynamic heterogeneity, characterized by the propensity of particles, is often used as a…

Disordered Systems and Neural Networks · Physics 2024-04-26 Yunrui Qiu , Inhyuk Jang , Xuhui Huang , Arun Yethiraj

After melting, at ambient pressure, the density of water continues to increase with temperature until it reaches a maximum around 4 {\deg}C. For nearly a century, this phenomenon has been qualitatively attributed to a mixture of ordered and…

Chemical Physics · Physics 2026-03-31 Yizhi Song , Renxi Liu , Chunyi Zhang , Yifan Li , Biswajit Santra , Mohan Chen , Michael L. Klein , Xifan Wu

Combining the principal component analysis (PCA) of X-ray spectrum with MD simulations, we experimentally reveal the existence of three basic components in water. These components exhibit distinct structures, densities, and temperature…

Soft Condensed Matter · Physics 2022-10-13 Zhipeng Jin , Jiangtao Zhao , Gang Chen , Guo Chen , Zhenlin Luo , Lei Xu

Within the so-called "no-man's land" between about 150 and 235 K, crystallization of bulk water is inevitable. The glasslike freezing and a liquid-to-liquid transition of water, predicted to occur in this region, can be investigated by…

Soft Condensed Matter · Physics 2020-09-17 Jonas K. H. Fischer , Pit Sippel , Dmytro Denysenko , Peter Lunkenheimer , Dirk Volkmer , Alois Loidl

We develop an approach to liquid thermodynamics based on collective modes. We perform extensive molecular dynamics simulations of noble, molecular and metallic liquids and provide the direct evidence that liquid energy and specific heat are…

Soft Condensed Matter · Physics 2017-03-08 L. Wang , C. Yang , M. T. Dove , Yu. D. Fomin , V. V. Brazhkin , K. Trachenko

One of the central problems of the liquid-glass transition is whether there is a structural signature that can qualitatively distinguish different dynamic behaviors at different degrees of supercooling. Here, we propose a novel structural…

Soft Condensed Matter · Physics 2015-09-24 Yan-Wei Li , You-Liang Zhu , Zhao-Yan Sun

Previous studies of the structure of liquid water under pressure performed by neutron diffraction, allowed us to establish two structural limits in liquid water. These two limits are closely connected to the two known forms of amorphous ice…

Disordered Systems and Neural Networks · Physics 2016-08-31 M. -C. Bellissent-Funel

The calculation of thermodynamic properties of biochemical systems typically requires the use of resource-intensive molecular simulation methods. One example thereof is the thermodynamic profiling of hydration sites, i.e. high-probability…

Biomolecules · Quantitative Biology 2020-01-08 Ahmadreza Ghanbarpour , Amr H. Mahmoud , Markus A. Lill

In this paper, we discuss theoretically the behavior of the four point nonlinear susceptibility and its associated correlation length for supercooled liquids close to the Mode Coupling instability temperature $T_c$. We work in the…

Disordered Systems and Neural Networks · Physics 2009-10-31 Silvio Franz , Giorgio Parisi

Water and silicon are chemically dissimilar substances with common physical properties. Their liquids display a temperature of maximum density, increased diffusivity on compression, they form tetrahedral crystals and tetrahedral amorphous…

Soft Condensed Matter · Physics 2008-09-18 Valeria Molinero , Emily B. Moore