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Out-of-distribution (OOD) detection is essential for determining when a supervised model encounters inputs that differ meaningfully from its training distribution. While widely studied in classification, OOD detection for regression and…

Machine Learning · Statistics 2025-12-16 Min Lu , Hemant Ishwaran

Deep learning has shown to have great potential in medical applications. In critical domains as such, it is of high interest to have trustworthy algorithms which are able to tell when reliable assessments cannot be guaranteed. Detecting…

Computer Vision and Pattern Recognition · Computer Science 2024-03-01 Jennie Karlsson , Marisa Wodrich , Niels Christian Overgaard , Freja Sahlin , Kristina Lång , Anders Heyden , Ida Arvidsson

Image classification models deployed in the real world may receive inputs outside the intended data distribution. For critical applications such as clinical decision making, it is important that a model can detect such out-of-distribution…

Computer Vision and Pattern Recognition · Computer Science 2021-07-07 Christoph Berger , Magdalini Paschali , Ben Glocker , Konstantinos Kamnitsas

Reliable out-of-distribution (OOD) detection is important for safe deployment of deep learning models in fetal ultrasound amidst heterogeneous image characteristics and clinical settings. OOD detection relies on estimating a classification…

Computer Vision and Pattern Recognition · Computer Science 2025-09-24 Chun Kit Wong , Anders N. Christensen , Cosmin I. Bercea , Julia A. Schnabel , Martin G. Tolsgaard , Aasa Feragen

Accurate detection and segmentation of cancerous lesions from computed tomography (CT) scans is essential for automated treatment planning and cancer treatment response assessment. Transformer-based models with self-supervised pretraining…

Image and Video Processing · Electrical Eng. & Systems 2026-01-29 Aneesh Rangnekar , Harini Veeraraghavan

Computer-aided diagnostics has benefited from the development of deep learning-based computer vision techniques in these years. Traditional supervised deep learning methods assume that the test sample is drawn from the identical…

Computer Vision and Pattern Recognition · Computer Science 2024-07-04 Zesheng Hong , Yubiao Yue , Yubin Chen , Lele Cong , Huanjie Lin , Yuanmei Luo , Mini Han Wang , Weidong Wang , Jialong Xu , Xiaoqi Yang , Hechang Chen , Zhenzhang Li , Sihong Xie

Accurate segmentation of lung tumors from 3D computed tomography (CT) scans is essential for automated treatment planning and response assessment. Despite self-supervised pretraining on numerous datasets, state-of-the-art transformer…

Image and Video Processing · Electrical Eng. & Systems 2026-04-24 Aneesh Rangnekar , Harini Veeraraghavan

Deep neural networks have shown promising results in disease detection and classification using medical image data. However, they still suffer from the challenges of handling real-world scenarios especially reliably detecting…

Image and Video Processing · Electrical Eng. & Systems 2021-11-03 Muhammad Zaida , Shafaqat Ali , Mohsen Ali , Sarfaraz Hussein , Asma Saadia , Waqas Sultani

The task of out-of-distribution (OOD) detection is notoriously ill-defined. Earlier works focused on new-class detection, aiming to identify label-altering data distribution shifts, also known as "semantic shift." However, recent works…

Computer Vision and Pattern Recognition · Computer Science 2024-03-20 William Yang , Byron Zhang , Olga Russakovsky

Out-of-distribution (OOD) detection aims to identify test examples that do not belong to the training distribution and are thus unlikely to be predicted reliably. Despite a plethora of existing works, most of them focused only on the…

Machine Learning · Computer Science 2023-11-07 Reza Averly , Wei-Lun Chao

To detect distribution shifts and improve model safety, many out-of-distribution (OOD) detection methods rely on the predictive uncertainty or features of supervised models trained on in-distribution data. In this paper, we critically…

Machine Learning · Computer Science 2025-07-03 Yucen Lily Li , Daohan Lu , Polina Kirichenko , Shikai Qiu , Tim G. J. Rudner , C. Bayan Bruss , Andrew Gordon Wilson

More than 10.7% of people aged 65 and older are affected by Alzheimer's disease. Early diagnosis and treatment are crucial as most Alzheimer's patients are unaware of having it until the effects become detrimental. AI has been known to use…

Image and Video Processing · Electrical Eng. & Systems 2023-09-19 Audrey Paleczny , Shubham Parab , Maxwell Zhang

Out-of-distribution (OOD) detection remains challenging for deep learning models, particularly when test-time OOD samples differ significantly from training outliers. We propose OODD, a novel test-time OOD detection method that dynamically…

Computer Vision and Pattern Recognition · Computer Science 2025-03-14 Yifeng Yang , Lin Zhu , Zewen Sun , Hengyu Liu , Qinying Gu , Nanyang Ye

Vanilla CNNs, as uncalibrated classifiers, suffer from classifying out-of-distribution (OOD) samples nearly as confidently as in-distribution samples. To tackle this challenge, some recent works have demonstrated the gains of leveraging…

Machine Learning · Computer Science 2020-11-20 Mahdieh Abbasi , Changjian Shui , Arezoo Rajabi , Christian Gagne , Rakesh Bobba

Obtaining accurate and valid information for drug molecules is a crucial and challenging task. However, chemical knowledge and information have been accumulated over the past 100 years from various regions, laboratories, and experimental…

Machine Learning · Computer Science 2023-10-12 Shuoying Wei , Xinlong Wen , Lida Zhu , Songquan Li , Rongbo Zhu

Out-of-distribution (OOD) detection is important for deploying machine learning models in the real world, where test data from shifted distributions can naturally arise. While a plethora of algorithmic approaches have recently emerged for…

Machine Learning · Computer Science 2021-12-03 Peyman Morteza , Yixuan Li

Out-of-Distribution (OOD) detection is essential for the trustworthiness of AI systems. Methods using prior information (i.e., subspace-based methods) have shown effective performance by extracting information geometry to detect OOD data…

Computer Vision and Pattern Recognition · Computer Science 2025-06-25 Kaiyu Guo , Zijian Wang , Tan Pan , Brian C. Lovell , Mahsa Baktashmotlagh

We present a systematic benchmark of out-of-distribution (OOD) detection CSFs through a representation-centric lens. Our study spans CNN and ViT backbones, multiple training paradigms, four image-classification source datasets (CIFAR-10,…

Machine Learning · Computer Science 2026-05-19 Claudio César Claros Olivares , Austin J. Brockmeier

This paper introduces a novel approach to securing machine learning model deployments against potential distribution shifts in practical applications, the Total Variation Out-of-Distribution (TV-OOD) detection method. Existing methods have…

Computer Vision and Pattern Recognition · Computer Science 2026-01-23 Dabiao Ma , Zhiba Su , Jian Yang , Haojun Fei

The superior performance of object detectors is often established under the condition that the test samples are in the same distribution as the training data. However, in many practical applications, out-of-distribution (OOD) instances are…

Computer Vision and Pattern Recognition · Computer Science 2023-10-31 Tianhao Zhang , Shenglin Wang , Nidhal Bouaynaya , Radu Calinescu , Lyudmila Mihaylova
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