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The Circle of Willis (CoW) is an important network of arteries connecting major circulations of the brain. Its vascular architecture is believed to affect the risk, severity, and clinical outcome of serious neurovascular diseases. However,…

Computer Vision and Pattern Recognition · Computer Science 2025-07-09 Kaiyuan Yang , Fabio Musio , Yihui Ma , Norman Juchler , Johannes C. Paetzold , Rami Al-Maskari , Luciano Höher , Hongwei Bran Li , Ibrahim Ethem Hamamci , Anjany Sekuboyina , Suprosanna Shit , Houjing Huang , Chinmay Prabhakar , Ezequiel de la Rosa , Bastian Wittmann , Diana Waldmannstetter , Florian Kofler , Fernando Navarro , Martin Menten , Ivan Ezhov , Daniel Rueckert , Iris N. Vos , Ynte M. Ruigrok , Birgitta K. Velthuis , Hugo J. Kuijf , Pengcheng Shi , Wei Liu , Ting Ma , Maximilian R. Rokuss , Yannick Kirchhoff , Fabian Isensee , Klaus Maier-Hein , Chengcheng Zhu , Huilin Zhao , Philippe Bijlenga , Julien Hämmerli , Catherine Wurster , Laura Westphal , Jeroen Bisschop , Elisa Colombo , Hakim Baazaoui , Hannah-Lea Handelsmann , Andrew Makmur , James Hallinan , Amrish Soundararajan , Bene Wiestler , Jan S. Kirschke , Roland Wiest , Emmanuel Montagnon , Laurent Letourneau-Guillon , Kwanseok Oh , Dahye Lee , Adam Hilbert , Orhun Utku Aydin , Dimitrios Rallios , Jana Rieger , Satoru Tanioka , Alexander Koch , Dietmar Frey , Abdul Qayyum , Moona Mazher , Steven Niederer , Nico Disch , Julius Holzschuh , Dominic LaBella , Francesco Galati , Daniele Falcetta , Maria A. Zuluaga , Chaolong Lin , Haoran Zhao , Zehan Zhang , Minghui Zhang , Xin You , Hanxiao Zhang , Guang-Zhong Yang , Yun Gu , Sinyoung Ra , Jongyun Hwang , Hyunjin Park , Junqiang Chen , Marek Wodzinski , Henning Müller , Nesrin Mansouri , Florent Autrusseau , Cansu Yalçin , Rachika E. Hamadache , Clara Lisazo , Joaquim Salvi , Adrià Casamitjana , Xavier Lladó , Uma Maria Lal-Trehan Estrada , Valeriia Abramova , Luca Giancardo , Arnau Oliver , Paula Casademunt , Adrian Galdran , Matteo Delucchi , Jialu Liu , Haibin Huang , Yue Cui , Zehang Lin , Yusheng Liu , Shunzhi Zhu , Tatsat R. Patel , Adnan H. Siddiqui , Vincent M. Tutino , Maysam Orouskhani , Huayu Wang , Mahmud Mossa-Basha , Yuki Sato , Sven Hirsch , Susanne Wegener , Bjoern Menze

The Circle of Willis (CoW) vessels is critical to connecting major circulations of the brain. The topology of the vascular structure is clinical significance to evaluate the risk, severity of the neuro-vascular diseases. The CoW has two…

Image and Video Processing · Electrical Eng. & Systems 2024-10-22 Minghui Zhang , Xin You , Hanxiao Zhang , Yun Gu

The Circle of Willis (CoW), vital for ensuring consistent blood flow to the brain, is closely linked to ischemic stroke. Accurate assessment of the CoW is important for identifying individuals at risk and guiding appropriate clinical…

Image and Video Processing · Electrical Eng. & Systems 2025-12-04 Wenxuan Zhang , Shuai Li , Xinyi Wang , Yu Sun , Hongyu Kang , Pui Yuk Chryste Wan , Jing Qin , Yuanpeng Zhang , Yong-Ping Zheng , Sai-Kit Lam

The Circle of Willis (CoW) is a critical network of arteries in the brain, often implicated in cerebrovascular pathologies. Voxel-level segmentation is an important first step toward an automated CoW assessment, but a full quantitative…

Computer Vision and Pattern Recognition · Computer Science 2025-10-16 Fabio Musio , Norman Juchler , Kaiyuan Yang , Suprosanna Shit , Chinmay Prabhakar , Bjoern Menze , Sven Hirsch

Accurate prediction of clinical scores is critical for early detection and prognosis of Alzheimers disease (AD). While existing approaches primarily focus on forecasting the ADAS-Cog global score, they often overlook the predictive value of…

Computer Vision and Pattern Recognition · Computer Science 2025-08-26 Nur Amirah Abd Hamid , Mohd Shahrizal Rusli , Muhammad Thaqif Iman Mohd Taufek , Mohd Ibrahim Shapiai , Daphne Teck Ching Lai

Rapid infarct assessment on non-contrast CT (NCCT) is essential for acute ischemic stroke management. Most deep learning methods perform pixel-wise segmentation without modeling the structured anatomical reasoning underlying ASPECTS…

Image and Video Processing · Electrical Eng. & Systems 2026-03-02 Hiba Azeem , Behraj Khan , Tahir Qasim Syed

Coronary artery disease is a leading cause of mortality, underscoring the critical importance of precise diagnosis through X-ray angiography. Manual coronary artery segmentation from these images is time-consuming and inefficient, prompting…

Image and Video Processing · Electrical Eng. & Systems 2025-09-04 Mingfeng Lin

The Alzheimer's Disease Assessment Scale-Cognitive subscale (ADAS-Cog) is a neuropsychological tool that has been designed to assess the severity of cognitive symptoms of dementia. Personalized prediction of the changes in ADAS-Cog scores…

Machine Learning · Computer Science 2021-09-22 Vandad Imani , Mithilesh Prakash , Marzieh Zare , Jussi Tohka

Most of the intracranial aneurysms (ICA) occur on a specific portion of the cerebral vascular tree named the Circle of Willis (CoW). More particularly, they mainly arise onto fifteen of the major arterial bifurcations constituting this…

Image and Video Processing · Electrical Eng. & Systems 2023-08-30 Rafic Nader , Romain Bourcier , Florent Autrusseau

In CT angiography, the accurate segmentation of abdominal aortic aneurysms (AAAs) is difficult due to large anatomical variability, low-contrast vessel boundaries, and the close proximity of organs whose intensities resemble vascular…

Computer Vision and Pattern Recognition · Computer Science 2026-04-14 Osamah Sufyan , Martin Brückmann , Ralph Wickenhöfer , Babette Dellen , Uwe Jaekel

Prognostic modeling is essential for forecasting future clinical scores and enabling early detection of Alzheimers disease (AD). While most existing methods focus on predicting the ADAS-Cog global score, they often overlook the predictive…

Computer Vision and Pattern Recognition · Computer Science 2025-08-26 Nur Amirah Abd Hamid , Mohd Ibrahim Shapiai , Daphne Teck Ching Lai

Ocular Myasthenia Gravis (OMG) is a rare and challenging disease to detect in its early stages, but symptoms often first appear in the eye muscles, such as drooping eyelids and double vision. Ocular images can be used for early diagnosis by…

Computer Vision and Pattern Recognition · Computer Science 2024-11-04 Ruiyu Xia , Jianqiang Li , Xi Xu , Guanghui Fu

Quantifying the distribution and morphology of tau protein structures in brain tissues is key to diagnosing Alzheimer's Disease (AD) and its subtypes. Recently, deep learning (DL) models such as UNet have been successfully used for…

Image and Video Processing · Electrical Eng. & Systems 2023-02-20 Gabriel Jimenez , Anuradha Kar , Mehdi Ounissi , Léa Ingrassia , Susana Boluda , Benoît Delatour , Lev Stimmer , Daniel Racoceanu

Lesion segmentation is an important problem in computer-assisted diagnosis that remains challenging due to the prevalence of low contrast, irregular boundaries that are unamenable to shape priors. We introduce Deep Active Lesion…

Image and Video Processing · Electrical Eng. & Systems 2020-09-01 Ali Hatamizadeh , Assaf Hoogi , Debleena Sengupta , Wuyue Lu , Brian Wilcox , Daniel Rubin , Demetri Terzopoulos

When delineating lesions from medical images, a human expert can always keep in mind the anatomical structure behind the voxels. However, although high-quality (though not perfect) anatomical information can be retrieved from computed…

Image and Video Processing · Electrical Eng. & Systems 2023-12-04 Rongzhao Zhang , Zhian Bai , Ruoying Yu , Wenrao Pang , Lingyun Wang , Lifeng Zhu , Xiaofan Zhang , Huan Zhang , Weiguo Hu

Deep neural networks (DNNs) often suffer from the overconfidence issue, where incorrect predictions are made with high confidence scores, hindering the applications in critical systems. In this paper, we propose a novel approach called…

Computer Vision and Pattern Recognition · Computer Science 2024-11-08 Yijun Liu , Jiequan Cui , Zhuotao Tian , Senqiao Yang , Qingdong He , Xiaoling Wang , Jingyong Su

Pathological alterations in the human vascular system underlie many chronic diseases, such as atherosclerosis and aneurysms. However, manually analyzing diagnostic images of the vascular system, such as computed tomographic angiograms…

Image and Video Processing · Electrical Eng. & Systems 2023-11-29 Alireza Bagheri Rajeoni , Breanna Pederson , Ali Firooz , Hamed Abdollahi , Andrew K. Smith , Daniel G. Clair , Susan M. Lessner , Homayoun Valafar

The application of deep learning models to large-scale data sets requires means for automatic quality assurance. We have previously developed a fully automatic algorithm for carotid artery wall segmentation in black-blood MRI that we aim to…

Image and Video Processing · Electrical Eng. & Systems 2023-08-21 Elina Thibeau-Sutre , Dieuwertje Alblas , Sophie Buurman , Christoph Brune , Jelmer M. Wolterink

Carotid artery vessel wall thickness measurement is an essential step in the monitoring of patients with atherosclerosis. This requires accurate segmentation of the vessel wall, i.e., the region between an artery's lumen and outer wall, in…

Image and Video Processing · Electrical Eng. & Systems 2021-12-03 Dieuwertje Alblas , Christoph Brune , Jelmer M. Wolterink

Importance: Coronary algorithm for cardiac sub structures and prospective real-time surveillance of cardiac dose exposure. Methods: Retro and prospective study to validate AI auto-segmentation. A 3D UNet was trained on 560 thoracic CT scans…

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