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The increasing use of synthetic data generated by Large Language Models (LLMs) presents both opportunities and challenges in data-driven applications. While synthetic data provides a cost-effective, scalable alternative to real-world data…

Computation and Language · Computer Science 2025-07-25 Tevin Atwal , Chan Nam Tieu , Yefeng Yuan , Zhan Shi , Yuhong Liu , Liang Cheng

Automatic detection of depression is a rapidly growing field of research at the intersection of psychology and machine learning. However, with its exponential interest comes a growing concern for data privacy and scarcity due to the…

Machine Learning · Computer Science 2024-11-27 Andrea Kang , Jun Yu Chen , Zoe Lee-Youngzie , Shuhao Fu

Machine learning (ML) models frequently rely on training data that may include sensitive or personal information, raising substantial privacy concerns. Legislative frameworks such as the General Data Protection Regulation (GDPR) and the…

Machine Learning · Computer Science 2024-12-31 Md Mahadi Hasan Nahid , Sadid Bin Hasan

The performance of modern machine learning systems depends on access to large, high-quality datasets, often sourced from user-generated content or proprietary, domain-specific corpora. However, these rich datasets inherently contain…

Cryptography and Security · Computer Science 2025-08-28 Zhan Shi , Yefeng Yuan , Yuhong Liu , Liang Cheng , Yi Fang

AI systems in healthcare research have shown potential to increase patient throughput and assist clinicians, yet progress is constrained by limited access to real patient data. To address this issue, we present a zero-shot, knowledge-guided…

Synthetic data generation using large language models (LLMs) demonstrates substantial promise in addressing biomedical data challenges and shows increasing adoption in biomedical research. This study systematically reviews recent advances…

Computation and Language · Computer Science 2026-02-18 Hanshu Rao , Weisi Liu , Haohan Wang , I-Chan Huang , Zhe He , Xiaolei Huang

Machine learning (ML) holds great promise for clinical applications but is often hindered by limited access to high-quality data due to privacy concerns, high costs, and long timelines associated with clinical trials. While large language…

Computation and Language · Computer Science 2026-03-27 Zerui Xu , Fang Wu , Yingzhou Lu , Yuanyuan Zhang , Yue Zhao

Large Language Models (LLMs) have emerged as powerful tools for generating data across various modalities. By transforming data from a scarce resource into a controllable asset, LLMs mitigate the bottlenecks imposed by the acquisition costs…

The process of matching patients with suitable clinical trials is essential for advancing medical research and providing optimal care. However, current approaches face challenges such as data standardization, ethical considerations, and a…

Computation and Language · Computer Science 2023-08-08 Jiayi Yuan , Ruixiang Tang , Xiaoqian Jiang , Xia Hu

The difficulty of anonymizing text data hinders the development and deployment of NLP in high-stakes domains that involve private data, such as healthcare and social services. Poorly anonymized sensitive data cannot be easily shared with…

Computation and Language · Computer Science 2024-10-14 Krithika Ramesh , Nupoor Gandhi , Pulkit Madaan , Lisa Bauer , Charith Peris , Anjalie Field

Access to real-world medical data is often restricted due to privacy regulations, posing a significant barrier to the advancement of healthcare research. Synthetic data offers a promising alternative; however, generating realistic,…

Artificial Intelligence · Computer Science 2025-08-13 Arshia Ilaty , Hossein Shirazi , Hajar Homayouni

The rapid advancements in generative AI and large language models (LLMs) have opened up new avenues for producing synthetic data, particularly in the realm of structured tabular formats, such as product reviews. Despite the potential…

Machine Learning · Computer Science 2025-07-25 Yefeng Yuan , Yuhong Liu , Liang Cheng

The collection and curation of high-quality training data is crucial for developing text classification models with superior performance, but it is often associated with significant costs and time investment. Researchers have recently…

Computation and Language · Computer Science 2023-10-16 Zhuoyan Li , Hangxiao Zhu , Zhuoran Lu , Ming Yin

Automated clinical text anonymization has the potential to unlock the widespread sharing of textual health data for secondary usage while assuring patient privacy and safety. Despite the proposal of many complex and theoretically successful…

Computation and Language · Computer Science 2024-06-05 David Pissarra , Isabel Curioso , João Alveira , Duarte Pereira , Bruno Ribeiro , Tomás Souper , Vasco Gomes , André V. Carreiro , Vitor Rolla

Large Language Models (LLMs) have demonstrated advanced capabilities in both text generation and comprehension, and their application to data archives might facilitate the privatization of sensitive information about the data subjects. In…

Cryptography and Security · Computer Science 2025-04-08 Stefano Cirillo , Domenico Desiato , Giuseppe Polese , Monica Maria Lucia Sebillo , Giandomenico Solimando

Large language models (LLMs) are emerging as promising tools for mental health care, offering scalable support through their ability to generate human-like responses. However, the effectiveness of these models in clinical settings remains…

Artificial Intelligence · Computer Science 2024-08-22 Yining Hua , Hongbin Na , Zehan Li , Fenglin Liu , Xiao Fang , David Clifton , John Torous

Large Language Models (LLMs) such as GPT-4 and Llama3 have significantly impacted various fields by enabling high-quality synthetic data generation and reducing dependence on expensive human-generated datasets. Despite this, challenges…

Computation and Language · Computer Science 2025-11-18 Yue Huang , Siyuan Wu , Chujie Gao , Dongping Chen , Qihui Zhang , Yao Wan , Tianyi Zhou , Jianfeng Gao , Chaowei Xiao , Lichao Sun , Xiangliang Zhang

The rise of Large Language Models (LLMs) has accentuated the need for diverse, high-quality pre-training data. Synthetic data emerges as a viable solution to the challenges of data scarcity and inaccessibility. While previous literature has…

Computation and Language · Computer Science 2024-10-24 Hao Chen , Abdul Waheed , Xiang Li , Yidong Wang , Jindong Wang , Bhiksha Raj , Marah I. Abdin

This study examines integrating EHRs and NLP with large language models (LLMs) to improve healthcare data management and patient care. It focuses on using advanced models to create secure, HIPAA-compliant synthetic patient notes for…

Computation and Language · Computer Science 2025-06-03 Yao-Shun Chuang , Atiquer Rahman Sarkar , Yu-Chun Hsu , Noman Mohammed , Xiaoqian Jiang

Large Language Models (LLMs) are increasingly adopted across domains such as education, healthcare, and finance. In healthcare, LLMs support tasks including disease diagnosis, abnormality classification, and clinical decision-making. Among…

Cryptography and Security · Computer Science 2026-03-31 Payel Bhattacharjee , Fengwei Tian , Geoffrey D. Rubin , Joseph Y. Lo , Nirav Merchant , Heidi Hanson , John Gounley , Ravi Tandon
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