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Large language models (LLMs) are useful tools with the capacity for performing specific types of knowledge work at an effective scale. However, LLM deployments in high-risk and safety-critical domains pose unique challenges, notably the…

Computation and Language · Computer Science 2024-09-05 Joe B Hakim , Jeffery L Painter , Darmendra Ramcharran , Vijay Kara , Greg Powell , Paulina Sobczak , Chiho Sato , Andrew Bate , Andrew Beam

Generative AI holds immense promise in addressing global healthcare access challenges, with numerous innovative applications now ready for use across various healthcare domains. However, a significant barrier to the widespread adoption of…

Cryptography and Security · Computer Science 2024-09-27 Ananya Gangavarapu

The remarkable capabilities of Large Language Models (LLMs) make them increasingly compelling for adoption in real-world healthcare applications. However, the risks associated with using LLMs in medical applications have not been…

Large language models are increasingly being used in patient-facing medical question answering, where hallucinated outputs can vary widely in potential harm. However, existing hallucination standards and evaluation metrics focus primarily…

Computation and Language · Computer Science 2026-03-02 Savan Doshi

Discharge summaries require extracting critical information from lengthy electronic health records (EHRs), a process that is labor-intensive when performed manually. Large language models (LLMs) can improve generation efficiency; however,…

Computation and Language · Computer Science 2026-05-06 Severin Ye , Xiao Kong , Xiaopeng He , Guangsu Yan , Dongsuk Oh

As large language models (LLMs) develop increasingly sophisticated capabilities and find applications in medical settings, it becomes important to assess their medical safety due to their far-reaching implications for personal and public…

Artificial Intelligence · Computer Science 2024-10-11 Tessa Han , Aounon Kumar , Chirag Agarwal , Himabindu Lakkaraju

With the widespread application of Large Language Models (LLMs), their associated security issues have become increasingly prominent, severely constraining their trustworthy deployment in critical domains. This paper proposes a novel safety…

Artificial Intelligence · Computer Science 2025-11-18 Qi Li , Jianjun Xu , Pingtao Wei , Jiu Li , Peiqiang Zhao , Jiwei Shi , Xuan Zhang , Yanhui Yang , Xiaodong Hui , Peng Xu , Wenqin Shao

Large language models (LLMs) have significantly advanced natural language processing tasks, yet they are susceptible to generating inaccurate or unreliable responses, a phenomenon known as hallucination. In critical domains such as health…

Computation and Language · Computer Science 2024-09-20 Sumera Anjum , Hanzhi Zhang , Wenjun Zhou , Eun Jin Paek , Xiaopeng Zhao , Yunhe Feng

The rapid advancement of large language models (LLMs) has significantly impacted various domains, including healthcare and biomedicine. However, the phenomenon of hallucination, where LLMs generate outputs that deviate from factual accuracy…

Computation and Language · Computer Science 2024-08-27 Duy Khoa Pham , Bao Quoc Vo

Large language models have proliferated across multiple domains in as short period of time. There is however hesitation in the medical and healthcare domain towards their adoption because of issues like factuality, coherence, and…

Computation and Language · Computer Science 2023-11-06 Muhammad Aurangzeb Ahmad , Ilker Yaramis , Taposh Dutta Roy

Large Language Models (LLMs) and Large Reasoning Models (LRMs) offer transformative potential for high-stakes domains like finance and law, but their tendency to hallucinate, generating factually incorrect or unsupported content, poses a…

Artificial Intelligence · Computer Science 2026-01-16 Ahmad Pesaranghader , Erin Li

Numerous medical systems powered by Large Language Models (LLMs) have achieved remarkable progress in diverse healthcare tasks. However, research on their medication safety remains limited due to the lack of real world datasets, constrained…

Artificial Intelligence · Computer Science 2025-11-07 Jiahao Zhao , Luxin Xu , Minghuan Tan , Lichao Zhang , Ahmadreza Argha , Hamid Alinejad-Rokny , Min Yang

Large language models (LLMs) are starting to complement traditional information seeking mechanisms such as web search. LLM-powered chatbots like ChatGPT are gaining prominence among the general public. AI chatbots are also increasingly…

Computation and Language · Computer Science 2025-11-25 Vibhor Agarwal , Yiqiao Jin , Mohit Chandra , Munmun De Choudhury , Srijan Kumar , Nishanth Sastry

Vision language models (VLMs) extend the reasoning capabilities of large language models (LLMs) to cross-modal settings, yet remain highly vulnerable to multimodal jailbreak attacks. Existing defenses predominantly rely on safety…

Artificial Intelligence · Computer Science 2026-04-14 Mengxuan Wang , Yuxin Chen , Gang Xu , Tao He , Hongjie Jiang , Ming Li

Clinical LLMs are often scaled by increasing model size, context length, retrieval complexity, or inference-time compute, with the implicit expectation that higher accuracy implies safer behavior. This assumption is incomplete in medicine,…

Multi-modal Large Language Models (MLLMs) have achieved remarkable performance across a wide range of visual reasoning tasks, yet their vulnerability to safety risks remains a pressing concern. While prior research primarily focuses on…

Computer Vision and Pattern Recognition · Computer Science 2026-03-18 Ce Zhang , Jinxi He , Junyi He , Katia Sycara , Yaqi Xie

Retrieval Augmented Generation (RAG), a paradigm that integrates external contextual information with large language models (LLMs) to enhance factual accuracy and relevance, has emerged as a pivotal area in generative AI. The LLMs used in…

Computation and Language · Computer Science 2024-09-17 Xuan-Phi Nguyen , Shrey Pandit , Senthil Purushwalkam , Austin Xu , Hailin Chen , Yifei Ming , Zixuan Ke , Silvio Savarese , Caiming Xong , Shafiq Joty

We present Wildflare GuardRail, a guardrail pipeline designed to enhance the safety and reliability of Large Language Model (LLM) inferences by systematically addressing risks across the entire processing workflow. Wildflare GuardRail…

Artificial Intelligence · Computer Science 2025-02-13 Shanshan Han , Salman Avestimehr , Chaoyang He

Medical Large Language Models (MLLMs) have demonstrated potential in healthcare applications, yet their propensity for hallucinations -- generating medically implausible or inaccurate information -- presents substantial risks to patient…

Computation and Language · Computer Science 2025-04-01 Kaiwen Zuo , Yirui Jiang

Large language models (LLMs) offer transformative potential for clinical decision support in spine surgery but pose significant risks through hallucinations, which are factually inconsistent or contextually misaligned outputs that may…

Machine Learning · Computer Science 2025-11-21 Dong Chen , Yanzhe Wei , Zonglin He , Guan-Ming Kuang , Canhua Ye , Meiru An , Huili Peng , Yong Hu , Huiren Tao , Kenneth MC Cheung
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