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Quantum annealing is a heuristic optimization algorithm that exploits quantum evolution to approximately find lowest energy states. Quantum annealers have scaled up in recent years to tackle increasingly larger and more highly connected…

Quantum Physics · Physics 2025-07-04 Humberto Munoz Bauza , Daniel A. Lidar

The quantum approximate optimization algorithm (QAOA) is a variational method for noisy, intermediate-scale quantum computers to solve combinatorial optimization problems. Quantifying performance bounds with respect to specific problem…

Quantum Physics · Physics 2021-11-30 Phillip C. Lotshaw , Travis S. Humble , Rebekah Herrman , James Ostrowski , George Siopsis

Quantum Machine Learning has the potential to improve traditional machine learning methods and overcome some of the main limitations imposed by the classical computing paradigm. However, the practical advantages of using quantum resources…

Quantum Physics · Physics 2023-03-21 Antonio Macaluso , Matthias Klusch , Stefano Lodi , Claudio Sartori

The Quantum Approximate Optimization Algorithm (QAOA) is a promising candidate algorithm for demonstrating quantum advantage in optimization using near-term quantum computers. However, QAOA has high requirements on gate fidelity due to the…

Quantum Physics · Physics 2023-03-20 Xiaoyuan Liu , Ruslan Shaydulin , Ilya Safro

Parameterized quantum circuits are attractive candidates for potential quantum advantage in the near term and beyond. At the same time, as quantum computing hardware not only continues to improve but also begins to incorporate new features…

Quantum Physics · Physics 2024-03-19 Tobias Stollenwerk , Stuart Hadfield

The Quantum Approximate Optimization Algorithm (QAOA) is a promising variational quantum algorithm introduced to tackle classically intractable combinatorial optimization problems. This tutorial offers a comprehensive, first-principles…

Quantum Physics · Physics 2025-11-25 Alessandro Giovagnoli

Molecular docking is a critical process for drug discovery and challenging due to the complexity and size of biomolecular systems, where the optimal binding configuration of a drug to a target protein is determined. Hybrid classical-quantum…

Emerging Technologies · Computer Science 2025-03-07 Christos Papalitsas , Yanfei Guan , Shreyas Waghe , Athanasios Liakos , Ioannis Balatsos , Vassilios Pantazopoulos

The intractability of deterministic solutions in solving $\mathcal{NP}$-Hard Combinatorial Optimisation Problems (COP) is well reported in the literature. One mechanism for overcoming this difficulty has been the use of efficient COP…

Quantum Physics · Physics 2022-04-25 Maxine T. Khumalo , Hazel A. Chieza , Krupa Prag , Matthew Woolway

We study algorithms inspired by quantum annealing that are suited for the NISQ era. First, we analyze approximate quantum annealing (AQA), which employs a discretized annealing ansatz in which the time step and the number of layers are…

Quantum Physics · Physics 2026-04-29 Rijul Sachdeva , Vrinda Mehta , Manpreet Singh Jattana , Kristel Michielsen , Fengping Jin

We present a detailed study of portfolio optimization using different versions of the quantum approximate optimization algorithm (QAOA). For a given list of assets, the portfolio optimization problem is formulated as quadratic binary…

We benchmark current annealing-based optimization workflows on a greenhouse-inspired quadratic unconstrained binary optimization problem for binary heater scheduling, where the horizon H denotes the number of hourly control decisions. For…

Quantum Physics · Physics 2026-05-28 Hamzeh Alavirad , Maryam Bahrami Zanjani

Despite extensive research efforts, few quantum algorithms for classical optimization demonstrate realizable quantum advantage. The utility of many quantum algorithms is limited by high requisite circuit depth and nonconvex optimization…

Quantum Physics · Physics 2022-01-27 Taylor L. Patti , Jean Kossaifi , Anima Anandkumar , Susanne F. Yelin

Quantum computers currently rely on a hybrid quantum-classical approach known as Variational Quantum Algorithms (VQAs) to solve problems. Still, there are several challenges with VQAs on the classical computing side: it corresponds to a…

Maximum cut (Max-Cut) problem is one of the most important combinatorial optimization problems because of its various applications in real life, and recently Quantum Approximate Optimization Algorithm (QAOA) has been widely employed to…

Quantum Physics · Physics 2023-07-31 Yiren Lu , Guojing Tian , Xiaoming Sun

The quantum approximate optimization algorithm (QAOA) is one of the most prominent proposed applications for near-term quantum computing. Here we study the ability of QAOA to solve hard constraint satisfaction problems, as opposed to…

Quantum Physics · Physics 2022-08-16 Sami Boulebnane , Ashley Montanaro

The quantum approximate optimization algorithm (QAOA) is a promising quantum algorithm that can be used to approximately solve combinatorial optimization problems. The usual QAOA ansatz consists of an alternating application of the cost and…

Quantum Physics · Physics 2024-11-01 Anthony Wilkie , Igor Gaidai , James Ostrowski , Rebekah Herrman

Although quantum computing hardware has evolved significantly in recent years, spurred by increasing industrial and government interest, the size limitation of current generation quantum computers remains an obstacle when applying these…

Quantum Physics · Physics 2020-01-20 Gideon Bass , Max Henderson , Joshua Heath , Joseph Dulny

Quantum enhanced optimization of classical cost functions is a central theme of quantum computing due to its high potential value in science and technology. The variational quantum eigensolver (VQE) and the quantum approximate optimization…

Quantum Physics · Physics 2024-11-27 Giuseppe Scriva , Nikita Astrakhantsev , Sebastiano Pilati , Guglielmo Mazzola

This paper proposes a novel combination of constraint encoding methods for the Quantum Approximate Optimization Ansatz (QAOA). Real-world optimization problems typically consist of multiple types of constraints. To solve these optimization…

Are quantum advantages in discrete manufacturing achievable in the near term? As manufacturing-relevant NISQ algorithms, we identified Quantum Annealing (QA) and the Quantum Approximate Optimization Algorithm (QAOA) for combinatorial…

Quantum Physics · Physics 2022-09-21 Oxana Shaya