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Molecular dynamics (MD) simulation is one of the past decade's most important tools for enabling biology scientists and researchers to explore human health and diseases. However, due to the computation complexity of the MD algorithm, it…

Computational Physics · Physics 2016-11-15 Jason Cong , Zhenman Fang , Hassan Kianinejad , Peng Wei

In addressing the Department of Energy's April, 2022 announcement of a Bold Decadal Vision for delivering a Fusion Pilot Plant by 2035, associated software tools need to be developed for the integration of real world engineering and supply…

While discrete-event simulators are essential tools for architecture research, design, and development, their practicality is limited by an extremely long time-to-solution for realistic applications under investigation. This work describes…

Hardware Architecture · Computer Science 2022-04-07 Lingda Li , Santosh Pandey , Thomas Flynn , Hang Liu , Noel Wheeler , Adolfy Hoisie

Experimental particle physics demands a sophisticated trigger and acquisition system capable to efficiently retain the collisions of interest for further investigation. Heterogeneous computing with the employment of FPGA cards may emerge as…

High Energy Physics - Experiment · Physics 2023-12-20 Andrea Coccaro , Francesco Armando Di Bello , Stefano Giagu , Lucrezia Rambelli , Nicola Stocchetti

Deep learning-based image compression (LIC) has achieved state-of-the-art rate-distortion (RD) performance, yet deploying these models on resource-constrained FPGAs remains a major challenge. This work presents a complete, multi-stage…

Computer Vision and Pattern Recognition · Computer Science 2025-11-24 Jiaxun Fang , Li Chen

In recent years, there has been tremendous advances in hardware acceleration of deep neural networks. However, most of the research has focused on optimizing accelerator microarchitecture for higher performance and energy efficiency on a…

Machine Learning · Computer Science 2019-12-12 Sam Likun Xi , Yuan Yao , Kshitij Bhardwaj , Paul Whatmough , Gu-Yeon Wei , David Brooks

Spiking Neural Networks (SNNs) have emerged as a biologically inspired alternative to conventional deep networks, offering event-driven and energy-efficient computation. However, their throughput remains constrained by the serial update of…

Neural and Evolutionary Computing · Computer Science 2026-03-16 Hongyang Shang , Shuai Dong , Yahan Yang , Junyi Yang , Peng Zhou , Arindam Basu

Single-molecule localization microscopy (SMLM) surpasses the diffraction limit, achieving subcellular resolution. Traditional SMLM analysis methods often rely on point spread function (PSF) model fitting, limiting the application of complex…

Quantitative Methods · Quantitative Biology 2024-10-04 Tingdan Luo

Fluorescence lifetime imaging (FLI) is a widely used technique in the biomedical field for measuring the decay times of fluorescent molecules, providing insights into metabolic states, protein interactions, and ligand-receptor bindings.…

Space missions increasingly deploy high-fidelity sensors that produce data volumes exceeding onboard buffering and downlink capacity. This work evaluates FPGA acceleration of neural networks (NNs) across four space use cases on the AMD…

Neural networks have become dominant computational workloads across cloud and edge platforms, but their rapid growth in model size and deployment diversity has exposed hardware bottlenecks increasingly dominated by memory movement,…

Systems and Control · Electrical Eng. & Systems 2026-01-16 Bin Xu , Ayan Banerjee , Sandeep Gupta

It is a challenging task to deploy computationally and memory intensive State-of-the-art deep neural networks (DNNs) on embedded systems with limited hardware resources and power budgets. Recently developed techniques like Deep Compression…

Computer Vision and Pattern Recognition · Computer Science 2018-04-13 Yuechao Gao , Nianhong Liu , Sheng Zhang

Predicting plasma evolution within a Tokamak reactor is crucial to realizing the goal of sustainable fusion. Capabilities in forecasting the spatio-temporal evolution of plasma rapidly and accurately allow us to quickly iterate over design…

Spiking Neural Networks (SNNs) have emerged as a promising approach to improve the energy efficiency of machine learning models, as they naturally implement event-driven computations while avoiding expensive multiplication operations. In…

Neural and Evolutionary Computing · Computer Science 2024-10-31 Anagha Nimbekar , Prabodh Katti , Chen Li , Bashir M. Al-Hashimi , Amit Acharyya , Bipin Rajendran

Recent advancements in neural network quantisation have yielded remarkable outcomes, with three-bit networks reaching state-of-the-art full-precision accuracy in complex tasks. These achievements present valuable opportunities for…

Hardware Architecture · Computer Science 2024-03-19 Daniel Gerlinghoff , Benjamin Chen Ming Choong , Rick Siow Mong Goh , Weng-Fai Wong , Tao Luo

Precise estimation of model inference latency is crucial for time-critical mobile edge applications, enabling devices to calculate latency margins against deadlines and trade them for enhanced model performance or resource savings. However,…

Hardware Architecture · Computer Science 2026-04-20 Jiesong Chen , Jun You , Zhidan Liu , Zhenjiang Li

The rapid development of programmable network devices and the widespread use of machine learning (ML) in networking have facilitated efficient research into intelligent data plane (IDP). Offloading ML to programmable data plane (PDP)…

Networking and Internet Architecture · Computer Science 2025-06-24 Mai Zhang , Lin Cui , Xiaoquan Zhang , Fung Po Tso , Zhen Zhang , Yuhui Deng , Zhetao Li

As the emerging field of machine learning, deep learning shows excellent ability in solving complex learning problems. However, the size of the networks becomes increasingly large scale due to the demands of the practical applications,…

Machine Learning · Computer Science 2016-05-24 Chao Wang , Qi Yu , Lei Gong , Xi Li , Yuan Xie , Xuehai Zhou

Convolutional neural nets (CNNs) have become a practical means to perform vision tasks, particularly in the area of image classification. FPGAs are well known to be able to perform convolutions efficiently, however, most recent efforts to…

Distributed, Parallel, and Cluster Computing · Computer Science 2017-01-16 Utku Aydonat , Shane O'Connell , Davor Capalija , Andrew C. Ling , Gordon R. Chiu

Artificial neural networks are already widely used for physics analysis, but there are only few applications within low-level hardware triggers, and typically only with small networks. Modern high-end FPGAs offer Tera-scale arithmetic…

Instrumentation and Detectors · Physics 2020-01-29 N. Nottbeck , C. Schmitt , V. Büscher