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Clinical machine learning models experience significantly degraded performance in datasets not seen during training, e.g., new hospitals or populations. Recent developments in domain generalization offer a promising solution to this problem…

Machine Learning · Computer Science 2021-04-16 Haoran Zhang , Natalie Dullerud , Laleh Seyyed-Kalantari , Quaid Morris , Shalmali Joshi , Marzyeh Ghassemi

Deep learning-based models in medical imaging often struggle to generalize effectively to new scans due to data heterogeneity arising from differences in hardware, acquisition parameters, population, and artifacts. This limitation presents…

Image and Video Processing · Electrical Eng. & Systems 2023-08-09 Sebastian Nørgaard Llambias , Mads Nielsen , Mostafa Mehdipour Ghazi

Deep networks are now ubiquitous in large-scale multi-center imaging studies. However, the direct aggregation of images across sites is contraindicated for downstream statistical and deep learning-based image analysis due to inconsistent…

Image and Video Processing · Electrical Eng. & Systems 2021-04-16 Mengwei Ren , Neel Dey , James Fishbaugh , Guido Gerig

Traditional domain generalization methods often rely on domain alignment to reduce inter-domain distribution differences and learn domain-invariant representations. However, domain shifts are inherently difficult to eliminate, which limits…

Computer Vision and Pattern Recognition · Computer Science 2024-12-10 Yuheng Xu , Taiping Zhang

Accurate and reliable histopathological image classification is essential for breast cancer diagnosis. However, many deep learning models remain sensitive to magnification variability and lack interpretability. To address these challenges,…

Computer Vision and Pattern Recognition · Computer Science 2026-03-17 Enam Ahmed Taufika , Md Ahasanul Arafatha , Abhijit Kumar Ghoshb , Md. Tanzim Rezab , Md Ashad Alamc

Generalising deep models to new data from new centres (termed here domains) remains a challenge. This is largely attributed to shifts in data statistics (domain shifts) between source and unseen domains. Recently, gradient-based…

Computer Vision and Pattern Recognition · Computer Science 2021-10-05 Xiao Liu , Spyridon Thermos , Alison O'Neil , Sotirios A. Tsaftaris

Deep learning models in medical image analysis often struggle with generalizability across domains and demographic groups due to data heterogeneity and scarcity. Traditional augmentation improves robustness, but fails under substantial…

Computer Vision and Pattern Recognition · Computer Science 2026-01-27 Sebastian Doerrich , Francesco Di Salvo , Jonas Alle , Christian Ledig

Background: Breast cancer has the highest prevalence in women globally. The classification and diagnosis of breast cancer and its histopathological images have always been a hot spot of clinical concern. In Computer-Aided Diagnosis (CAD),…

Computer Vision and Pattern Recognition · Computer Science 2022-05-11 Yuchao Zheng , Chen Li , Xiaomin Zhou , Haoyuan Chen , Hao Xu , Yixin Li , Haiqing Zhang , Xiaoyan Li , Hongzan Sun , Xinyu Huang , Marcin Grzegorzek

During the past decade, deep neural networks have led to fast-paced progress and significant achievements in computer vision problems, for both academia and industry. Yet despite their success, state-of-the-art image classification…

Computer Vision and Pattern Recognition · Computer Science 2024-05-13 Aristotelis Ballas , Christos Diou

The automated analysis of medical images is currently limited by technical and biological noise and bias. The same source tissue can be represented by vastly different images if the image acquisition or processing protocols vary. For an…

Ki67 is a significant biomarker in the diagnosis and prognosis of cancer, whose index can be evaluated by quantifying its expression in Ki67 immunohistochemistry (IHC) stained images. However, quantitative analysis on multi-source Ki67…

Computer Vision and Pattern Recognition · Computer Science 2021-07-07 Jiatong Cai , Chenglu Zhu , Can Cui , Honglin Li , Tong Wu , Shichuan Zhang , Lin Yang

Domain generalization in computational histopathology is hindered by heterogeneity in whole slide images (WSIs), caused by variations in tissue preparation, staining, and imaging conditions across institutions. Unlike machine learning…

Computer Vision and Pattern Recognition · Computer Science 2025-09-03 Hikmat Khan , Syed Farhan Alam Zaidi , Pir Masoom Shah , Kiruthika Balakrishnan , Rabia Khan , Muhammad Waqas , Jia Wu

Achieving domain generalization in medical imaging poses a significant challenge, primarily due to the limited availability of publicly labeled datasets in this domain. This limitation arises from concerns related to data privacy and the…

Image and Video Processing · Electrical Eng. & Systems 2024-07-23 Ahmed Radwan , Islam Osman , Mohamed S. Shehata

Cross-modal MRI segmentation is of great value for computer-aided medical diagnosis, enabling flexible data acquisition and model generalization. However, most existing methods have difficulty in handling local variations in domain shift…

Computer Vision and Pattern Recognition · Computer Science 2023-11-17 Bingnan Li , Zhitong Gao , Xuming He

Recapturing and rebroadcasting of images are common attack methods in insurance frauds and face identification spoofing, and an increasing number of detection techniques were introduced to handle this problem. However, most of them ignored…

Computer Vision and Pattern Recognition · Computer Science 2021-10-08 Jinian Luo , Jie Guo , Weidong Qiu , Zheng Huang , Hong Hui

We propose an exhaustive methodology that leverages all levels of feature abstraction, targeting an enhancement in the generalizability of image classification to unobserved hospitals. Our approach incorporates augmentation-based…

Computer Vision and Pattern Recognition · Computer Science 2023-08-10 Milad Sikaroudi , Maryam Hosseini , Shahryar Rahnamayan , H. R. Tizhoosh

Domain-invariant representation learning is a powerful method for domain generalization. Previous approaches face challenges such as high computational demands, training instability, and limited effectiveness with high-dimensional data,…

Computer Vision and Pattern Recognition · Computer Science 2024-11-25 Yuheng Xu , Taiping Zhang

In recent years, a standard computational pathology workflow has emerged where whole slide images are cropped into tiles, these tiles are processed using a foundation model, and task-specific models are built using the resulting…

Computer Vision and Pattern Recognition · Computer Science 2026-02-26 Eric Zimmermann , Julian Viret , Michal Zelechowski , James Brian Hall , Neil Tenenholtz , Adam Casson , George Shaikovski , Eugene Vorontsov , Siqi Liu , Kristen A Severson

Domain generalization aims to train models on multiple source domains so that they can generalize well to unseen target domains. Among many domain generalization methods, Fourier-transform-based domain generalization methods have gained…

Image and Video Processing · Electrical Eng. & Systems 2023-12-14 Hongyi Pan , Bin Wang , Zheyuan Zhang , Xin Zhu , Debesh Jha , Ahmet Enis Cetin , Concetto Spampinato , Ulas Bagci

Diabetic Retinopathy (DR) constitutes 5% of global blindness cases. While numerous deep learning approaches have sought to enhance traditional DR grading methods, they often falter when confronted with new out-of-distribution data thereby…

Image and Video Processing · Electrical Eng. & Systems 2024-11-06 Sharon Chokuwa , Muhammad Haris Khan