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Background: Electronic Health Records (EHRs) contain rich information of patients' health history, which usually include both structured and unstructured data. There have been many studies focusing on distilling valuable information from…

Machine Learning · Computer Science 2021-11-10 Ziyi Liu , Jiaqi Zhang , Yongshuai Hou , Xinran Zhang , Ge Li , Yang Xiang

Detailed phenotype information is fundamental to accurate diagnosis and risk estimation of diseases. As a rich source of phenotype information, electronic health records (EHRs) promise to empower diagnostic variant interpretation. However,…

Machine Learning · Computer Science 2023-04-28 Shenghan Zhang , Haoxuan Li , Ruixiang Tang , Sirui Ding , Laila Rasmy , Degui Zhi , Na Zou , Xia Hu

Entity Linking (EL), the task of mapping textual entity mentions to their corresponding entries in knowledge bases, constitutes a fundamental component of natural language understanding. Recent advancements in Large Language Models (LLMs)…

Computation and Language · Computer Science 2025-11-19 Jiajun Hou , Chenyu Zhang , Rui Meng

Medical consultation dialogues contain critical clinical information, yet their unstructured nature hinders effective utilization in diagnosis and treatment. Traditional methods, relying on rule-based or shallow machine learning techniques,…

Computation and Language · Computer Science 2025-04-24 Shuguang Zhao , Qiangzhong Feng , Zhiyang He , Peipei Sun , Yingying Wang , Xiaodong Tao , Xiaoliang Lu , Mei Cheng , Xinyue Wu , Yanyan Wang , Wei Liang

Identifying disease interconnections through manual analysis of large-scale clinical data is labor-intensive, subjective, and prone to expert disagreement. While machine learning (ML) shows promise, three critical challenges remain: (1)…

Entity alignment, which is a prerequisite for creating a more comprehensive Knowledge Graph (KG), involves pinpointing equivalent entities across disparate KGs. Contemporary methods for entity alignment have predominantly utilized knowledge…

Computation and Language · Computer Science 2024-01-31 Linyao Yang , Hongyang Chen , Xiao Wang , Jing Yang , Fei-Yue Wang , Han Liu

Electronic Health Records (EHRs) and routine documentation practices play a vital role in patients' daily care, providing a holistic record of health, diagnoses, and treatment. However, complex and verbose EHR narratives overload healthcare…

Computation and Language · Computer Science 2025-02-26 Yanjun Gao , Ruizhe Li , Emma Croxford , John Caskey , Brian W Patterson , Matthew Churpek , Timothy Miller , Dmitriy Dligach , Majid Afshar

Pre-trained Large Language Models (LLMs) often struggle on out-of-domain datasets like healthcare focused text. We explore specialized pre-training to adapt smaller LLMs to different healthcare datasets. Three methods are assessed:…

Computation and Language · Computer Science 2024-04-01 Niall Taylor , Dan Schofield , Andrey Kormilitzin , Dan W Joyce , Alejo Nevado-Holgado

Healthcare domain generates a lot of unstructured and semi-structured text. Natural Language processing (NLP) has been used extensively to process this data. Deep Learning based NLP especially Large Language Models (LLMs) such as BERT have…

Computation and Language · Computer Science 2023-01-11 Kunal Suri , Atul Singh , Prakhar Mishra , Swapna Sourav Rout , Rajesh Sabapathy

Recent advances in artificial intelligence, particularly large language models LLMs, have shown promising capabilities in transforming rare disease research. This survey paper explores the integration of LLMs in the analysis of rare…

Computation and Language · Computer Science 2025-05-26 Valentina Carbonari , Pierangelo Veltri , Pietro Hiram Guzzi

Background: Machine learning methods for clinical named entity recognition and entity normalization systems can utilize both labeled corpora and Knowledge Graphs (KGs) for learning. However, infrequently occurring concepts may have few…

Computation and Language · Computer Science 2024-10-11 Kuleen Sasse , Shinjitha Vadlakonda , Richard E. Kennedy , John D. Osborne

Multimodal Entity Linking (MEL) is a fundamental task in data management that maps ambiguous mentions with diverse modalities to the multimodal entities in a knowledge base. However, most existing MEL approaches primarily focus on…

Computation and Language · Computer Science 2026-04-23 Mo Zhou , Jianwei Wang , Kai Wang , Helen Paik , Ying Zhang , Wenjie Zhang

Entity and relation extraction is a key task in information extraction, where the output can be used for downstream NLP tasks. Existing approaches for entity and relation extraction tasks mainly focus on the English corpora and ignore other…

Computation and Language · Computer Science 2023-01-12 Zixiang Wang , Jian Yang , Tongliang Li , Jiaheng Liu , Ying Mo , Jiaqi Bai , Longtao He , Zhoujun Li

We propose TG-LMM (Text-Guided Large Multi-Modal Model), a novel approach that leverages textual descriptions of organs to enhance segmentation accuracy in medical images. Existing medical image segmentation methods face several challenges:…

Computer Vision and Pattern Recognition · Computer Science 2024-09-06 Yihao Zhao , Enhao Zhong , Cuiyun Yuan , Yang Li , Man Zhao , Chunxia Li , Jun Hu , Chenbin Liu

Despite significant advancements in medical vision-language pre-training, existing methods have largely overlooked the inherent linguistic complexity and imbalanced isssue within medical reports, as well as the complex cross-modality…

Computer Vision and Pattern Recognition · Computer Science 2025-06-10 Rongsheng Wang , Qingsong Yao , Zihang Jiang , Haoran Lai , Zhiyang He , Xiaodong Tao , S. Kevin Zhou

Large language models (LLMs) show increasing promise in medical applications, but their ability to detect and correct errors in clinical texts -- a prerequisite for safe deployment -- remains under-evaluated, particularly beyond English. We…

Computation and Language · Computer Science 2025-11-04 Naoto Iwase , Hiroki Okuyama , Junichiro Iwasawa

Systematic reviews and meta-analyses rely on converting narrative articles into structured, numerically grounded study records. Despite rapid advances in large language models (LLMs), it remains unclear whether they can meet the structural…

Computation and Language · Computer Science 2026-02-12 Zhiyin Tan , Jennifer D'Souza

In this work, we introduce the Multiple Embedding Model for EHR (MEME), an approach that serializes multimodal EHR tabular data into text using pseudo-notes, mimicking clinical text generation. This conversion not only preserves better…

Computation and Language · Computer Science 2025-07-08 Simon A. Lee , Sujay Jain , Alex Chen , Kyoka Ono , Jennifer Fang , Akos Rudas , Jeffrey N. Chiang

The ever-growing volume of biomedical publications creates a critical need for efficient knowledge discovery. In this context, we introduce an open-source end-to-end framework designed to construct knowledge around specific diseases…

Computation and Language · Computer Science 2024-12-05 Christos Theodoropoulos , Andrei Catalin Coman , James Henderson , Marie-Francine Moens

Manual chart review remains an extremely time-consuming and resource-intensive component of clinical research, requiring experts to extract often complex information from unstructured electronic health record (EHR) narratives. We present a…