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The Keller-Segel model is a system of partial differential equations modelling chemotactic aggregation in cellular systems. This model has blowing up solutions for large enough initial conditions in dimensions d >= 2, but all the solutions…

Analysis of PDEs · Mathematics 2009-11-11 Carlos Escudero

In this paper, we propose and study a stochastic aggregation-diffusion equation of the Keller-Segel (KS) type for modeling the chemotaxis in dimensions $d=2,3$. Unlike the classical deterministic KS system, which only allows for…

Analysis of PDEs · Mathematics 2020-09-23 Hui Huang , Jinniao Qiu

We introduce stochastic models of chemotaxis generalizing the deterministic Keller-Segel model. These models include fluctuations which are important in systems with small particle numbers or close to a critical point. Following Dean's…

Statistical Mechanics · Physics 2009-09-01 Pierre-Henri Chavanis

Chemotaxis systems of Keller--Segel type constitute one of the central mathematical frameworks for understanding aggregation phenomena in biological and ecological systems. Over the past decades, the theory has evolved from the classical…

Analysis of PDEs · Mathematics 2026-03-06 Kolade M Owolabi , Eben Mare , Clara O Ijalana , Kolawole S Adegbie

Simulations are performed to investigate the nonlinear dynamics of a (2+1)-dimensional chemotaxis model of Keller-Segel (KS) type with a logistic growth term. Because of its ability to display auto-aggregation, the KS model has been widely…

Biological Physics · Physics 2011-11-14 S. Banerjee , A. P. Misra , L. Rondoni

This paper is concerned with numerical approximation of some two-dimensional Keller-Segel chemotaxis models, especially those generating pattern formations. The numerical resolution of such nonlinear parabolic-parabolic or…

Numerical Analysis · Mathematics 2020-10-29 M. Benzakour Amine

We are concerned with the hyperbolic Keller-Segel model with quorum sensing, a model describing the collective cell movement due to chemical signalling with a flux limitation for high cell densities. This is a first order quasilinear…

Analysis of PDEs · Mathematics 2007-05-23 Benoit Perthame , Anne-Laure Dalibard

Extended systems governed by partial differential equations can, under suitable conditions, be approximated by means of sets of ordinary differential equations for global quantities capturing the essential features of the systems dynamics.…

Quantitative Methods · Quantitative Biology 2015-06-18 Juan Belmonte-Beitia , Gabriel F. Calvo , Victor M. Perez-Garcia

We present a discrete model of chemotaxis whereby cells responding to a chemoattractant are seen as individual agents whose movement is described through a set of rules that result in a biased random walk. In order to take into account…

Analysis of PDEs · Mathematics 2020-03-27 Federica Bubba , Tommaso Lorenzi , Fiona R Macfarlane

The aim of this paper is to provide the analysis result for the partial differential equations arising from the rigorous derivation of the degenerate parabolic-elliptic Keller-Segel system from a moderately interacting stochastic particle…

Analysis of PDEs · Mathematics 2023-01-20 Li Chen , Veniamin Gvozdik , Yue Li

The Keller--Segel PDE is a model for chemotaxis known to exhibit possible finite-time blow-up. Following a seminal work by Tello and Winkler, a logistic damping term is added in this PDE and local well-posedness of mild solutions is proven.…

Probability · Mathematics 2025-12-24 Thomas Cavallazzi , Alexandre Richard , Milica Tomasevic

We analyze the existence, linear stability, and slow dynamics of localized 1D spike patterns for a Keller--Segel model of chemotaxis that includes the effect of logistic growth of the cellular population. Our analysis of localized patterns…

Analysis of PDEs · Mathematics 2023-08-01 Fanze Kong , Michael Ward , Juncheng Wei

We develop a new four-phase tumor growth model with angiogenesis, derived from a diffuse-interface mixture model composed by a viable, a necrotic, a liquid and an angiogenetic component, coupled with two massless chemicals representing a…

Numerical Analysis · Mathematics 2022-03-07 Abramo Agosti , Alice Giotta Lucifero , Sabino Luzzi

We study a regularized interacting particle method for computing aggregation patterns and near singular solutions of a Keller-Segal (KS) chemotaxis system in two and three space dimensions, then further develop DeepParticle (DP) method to…

Computational Physics · Physics 2024-01-30 Zhongjian Wang , Jack Xin , Zhiwen Zhang

This paper considers the Keller-Segel model coupled to stochastic Navier-Stokes equations (KS-SNS, for short), which describes the dynamics of oxygen and bacteria densities evolving within a stochastically forced 2D incompressible viscous…

Analysis of PDEs · Mathematics 2024-08-02 Lei Zhang , Bin Liu

Personalized medicine based on medical images, including predicting future individualized clinical disease progression and treatment response, would have an enormous impact on healthcare and drug development, particularly for diseases (e.g.…

Artificial Intelligence · Computer Science 2024-06-19 Joshua Durso-Finley , Berardino Barile , Jean-Pierre Falet , Douglas L. Arnold , Nick Pawlowski , Tal Arbel

In this paper, we address a distributed control problem for a system of partial differential equations describing the evolution of a tumor that takes the biological mechanism of chemotaxis into account. The system describing the evolution…

Optimization and Control · Mathematics 2023-09-19 Gianni Gilardi , Andrea Signori , Jürgen Sprekels

The Keller-Segel system describes the collective motion of cells that are attracted by a chemical substance and are able to emit it. In its simplest form, it is a conservative drift-diffusion equation for the cell density coupled to an…

Analysis of PDEs · Mathematics 2010-10-29 Adrien Blanchet , Jean Dolbeault , Miguel Escobedo , Javier Fernández

The Keller-Segel system has been widely proposed as a model for bacterial waves driven by chemotactic processes. Current experiments on {\em E. coli} have shown precise structure of traveling pulses. We present here an alternative…

We investigate nonlinear dynamics near an unstable constant equilibrium in the classical Keller-Segel model. Given any general perturbation of magnitude $\delta$, we prove that its nonlinear evolution is dominated by the corresponding…

Analysis of PDEs · Mathematics 2007-05-23 Yan Guo , Hyung Ju Hwang
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