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Cancer is a disease driven by random DNA mutations and the interaction of many complex phenomena. To improve the understanding and ultimately find more effective treatments, researchers leverage computer simulations mimicking the tumor…
Tuberculosis (TB) is a contagious disease that causes 1.5 million deaths per year globally. Early diagnosis of TB patients is critical to control its spread. However, standard TB diagnostic tests such as sputum culture take days to weeks to…
Obesity is a global epidemic causing at least 2.8 million deaths per year. This complex disease is associated with significant socioeconomic burden, reduced work productivity, unemployment, and other social determinants of Health (SDoH)…
Atherosclerosis is a chronic inflammatory disease occurs due to plaque accumulation in the inner artery wall. In atherosclerotic plaque formation monocytes and macrophages play a significant role in controlling the disease dynamics. In the…
Cardiovascular diseases (CVDs) are a main cause of mortality globally, accounting for 31% of all deaths. This study involves a cardiovascular disease (CVD) dataset comprising 68,119 records to explore the influence of numerical (age,…
Automatic classification of active tuberculosis from chest X-ray images has the potential to save lives, especially in low- and mid-income countries where skilled human experts can be scarce. Given the lack of available labeled data to…
Agent-based simulators (ABS) are a popular epidemiological modelling tool to study the impact of various non-pharmaceutical interventions in managing an epidemic in a city (or a region). They provide the flexibility to accurately model a…
Vector-borne epidemics are the result of the combination of different factors such as the crossed contagions between humans and vectors, their demographic distribution and human mobility among others. The current availability of information…
Objective: The automatic discrimination between the coughing sounds produced by patients with tuberculosis (TB) and those produced by patients with other lung ailments. Approach: We present experiments based on a dataset of 1358 forced…
Digital Adherence Technologies (DATs) are an increasingly popular method for verifying patient adherence to many medications. We analyze data from one city served by 99DOTS, a phone-call-based DAT deployed for Tuberculosis (TB) treatment in…
Bacterial Vaginosis (BV) affects nearly 23-29% of women worldwide and increases risk of miscarriage, preterm birth, and sexually transmitted infections. It involves a shift in the vaginal microbiome from Lactobacillus dominance to a diverse…
Obesity is a major health problem, increasing the risk of various major chronic diseases, such as diabetes, cancer, and stroke. While the role of obesity identified by cross-sectional BMI recordings has been heavily studied, the role of BMI…
Meta-population networks are effective tools for capturing population movement across distinct regions, but the assumption of well-mixed regions fails to capture the reality of population higher-order interactions. As a multidimensional…
Bacteriophages are viruses infecting bacteria and archaea. Many phage species cause infections which lead to the certain death of the infected prokaryotic host cell and the release of a large batch of phage progeny, yet they have been able…
During the last decades, the global prevalence of dengue progressed dramatically. It is a disease that is now endemic in more than one hundred countries of Africa, America, Asia, and the Western Pacific. In this paper, we present a…
Oxidative stress, a reaction caused by the imbalance between the reactive oxygen species of human organism and its ability to detoxify reactive intermediates and to repair the resulting damage plays an important role in HIV-infections. On…
Recent work has attempted to use whole-genome sequence data from pathogens to reconstruct the transmission trees linking infectors and infectees in outbreaks. However, transmission trees from one outbreak do not generalize to future…
A widely-used model for determining the long-term health impacts of public health interventions, often called a "multistate lifetable", requires estimates of incidence, case fatality, and sometimes also remission rates, for multiple…
This study investigates the interplay among social demographics, built environment characteristics, and environmental hazard exposure features in determining community level cancer prevalence. Utilizing data from five Metropolitan…
In 2014, a major epidemic of human Ebola virus disease emerged in West Africa, where human-to-human transmission has now been been sustained for greater than 10 months. In the summer of 2014, there was great uncertainty about the answers to…