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The aim of multimodal neural networks is to combine diverse data sources, referred to as modalities, to achieve enhanced performance compared to relying on a single modality. However, training of multimodal networks is typically hindered by…

Machine Learning · Computer Science 2025-10-21 Alejandro Guerra-Manzanares , Farah E. Shamout

Large scale pretrained language models have demonstrated state-of-the-art performance in language understanding tasks. Their application has recently expanded into multimodality learning, leading to improved representations combining vision…

Computation and Language · Computer Science 2021-09-06 Michael Sollami , Aashish Jain

Large language models equipped with retrieval-augmented generation (RAG) represent a burgeoning field aimed at enhancing answering capabilities by leveraging external knowledge bases. Although the application of RAG with language-only…

Computer Vision and Pattern Recognition · Computer Science 2024-06-03 Cheng Tan , Jingxuan Wei , Linzhuang Sun , Zhangyang Gao , Siyuan Li , Bihui Yu , Ruifeng Guo , Stan Z. Li

Understanding the intricate interplay among sequence, structure, and function remains a fundamental challenge in proteomics. The sequence-structure-function paradigm posits that biological roles are governed by the tertiary geometric…

Biomolecules · Quantitative Biology 2026-05-14 Hongwang Xiao , Wenjun Lin , Xi Chen , Hui Wang , Kai Chen , Jiashan Li , Yuancheng Sun , Sicheng Dai , Boya Wu , Qiwei Ye

The regulation of various cellular processes heavily relies on the protein complexes within a living cell, necessitating a comprehensive understanding of their three-dimensional structures to elucidate the underlying mechanisms. While…

Biomolecules · Quantitative Biology 2023-05-26 Yuanfeng Ji , Yatao Bian , Guoji Fu , Peilin Zhao , Ping Luo

Malignant brain tumors have become an aggressive and dangerous disease that leads to death worldwide.Multi-modal MRI data is crucial for accurate brain tumor segmentation, but missing modalities common in clinical practice can severely…

Methodology · Statistics 2025-07-11 Guoyan Liang , Qin Zhou , Jingyuan Chen , Bingcang Huang , Kai Chen , Lin Gu , Zhe Wang , Sai Wu , Chang Yao

Unified multimodal models integrate the reasoning capacity of large language models with both image understanding and generation, showing great promise for advanced multimodal intelligence. However, the community still lacks a rigorous…

Computer Vision and Pattern Recognition · Computer Science 2026-03-24 Hongxiang Li , Yaowei Li , Bin Lin , Yuwei Niu , Yuhang Yang , Xiaoshuang Huang , Jiayin Cai , Xiaolong Jiang , Yao Hu , Long Chen

Multimodal data provides heterogeneous information for a holistic understanding of the tumor microenvironment. However, existing AI models often struggle to harness the rich information within multimodal data and extract poorly…

Machine Learning · Computer Science 2025-09-17 Huajun Zhou , Fengtao Zhou , Jiabo Ma , Yingxue Xu , Xi Wang , Xiuming Zhang , Li Liang , Zhenhui Li , Hao Chen

Biomedical data is inherently multimodal, comprising physical measurements and natural language narratives. A generalist biomedical AI model needs to simultaneously process different modalities of data, including text and images. Therefore,…

Since the resurgence of deep learning, vision-language models (VLMs) enhanced by large language models (LLMs) have grown exponentially in popularity. However, while LLMs can utilize extensive background knowledge and task information with…

Computation and Language · Computer Science 2024-03-21 Haozhe Zhao , Zefan Cai , Shuzheng Si , Xiaojian Ma , Kaikai An , Liang Chen , Zixuan Liu , Sheng Wang , Wenjuan Han , Baobao Chang

Large language models have emerged as transformative tools in molecular science, demonstrating remarkable potential in molecular property prediction and de novo molecular design. However, their application to spectroscopy remains notably…

Machine Learning · Computer Science 2026-03-24 Shuaike Shen , Jiaqing Xie , Zhuo Yang , Antong Zhang , Shuzhou Sun , Ben Gao , Tianfan Fu , Biqing Qi , Yuqiang Li

Recently, In-context Learning (ICL) has become a significant inference paradigm in Large Multimodal Models (LMMs), utilizing a few in-context demonstrations (ICDs) to prompt LMMs for new tasks. However, the synergistic effects in multimodal…

Machine Learning · Computer Science 2025-05-20 Yuchu Jiang , Jiale Fu , Chenduo Hao , Xinting Hu , Yingzhe Peng , Xin Geng , Xu Yang

Learning holistic computational representations in physical, chemical or biological systems requires the ability to process information from different distributions and modalities within the same model. Thus, the demand for multimodal…

Machine Learning · Computer Science 2025-04-17 Konstantin Hemker , Nikola Simidjievski , Mateja Jamnik

Generative modeling has emerged as a powerful paradigm for representation learning, but its direct applicability to challenging fields like medical imaging remains limited: mere generation, without task alignment, fails to provide a robust…

Machine Learning · Computer Science 2025-10-28 Luca Caldera , Giacomo Bottacini , Lara Cavinato

As key elements within the central dogma, DNA, RNA, and proteins play crucial roles in maintaining life by guaranteeing accurate genetic expression and implementation. Although research on these molecules has profoundly impacted fields like…

Real-world multimodal learning is often hindered by missing modalities. While Incomplete Multimodal Learning (IML) has gained traction, existing methods typically rely on the unrealistic assumption of full-modal availability during training…

Computer Vision and Pattern Recognition · Computer Science 2026-05-04 Huangbiao Xu , Huanqi Wu , Xiao Ke , Yuxin Peng

Effective clinical decision-making depends on iterative, multimodal reasoning across diverse sources of evidence. The recent emergence of multimodal reasoning models has significantly transformed the landscape of solving complex tasks.…

Computation and Language · Computer Science 2025-11-04 Zhongzhen Huang , Linjie Mu , Yakun Zhu , Xiangyu Zhao , Shaoting Zhang , Xiaofan Zhang

Molecular structure elucidation from spectroscopic data is a long-standing challenge in Chemistry, traditionally requiring expert interpretation. We introduce NMIRacle, a two-stage generative framework that builds upon recent paradigms in…

Chemical Physics · Physics 2026-03-12 Federico Ottomano , Yingzhen Li , Alex M. Ganose

MLLMs have been successfully applied to multimodal embedding tasks, yet their generative reasoning capabilities remain underutilized. Directly incorporating chain-of-thought reasoning into embedding learning introduces two fundamental…

Computer Vision and Pattern Recognition · Computer Science 2026-04-08 Yuchi Wang , Haiyang Yu , Weikang Bian , Jiefeng Long , Xiao Liang , Chao Feng , Hongsheng Li

The remarkable success of multimodal large language models (MLLMs) has driven advances in multimodal embeddings, yet existing models remain inherently discriminative, limiting their ability to benefit from reasoning-driven generation…

Machine Learning · Computer Science 2026-03-03 Zhibin Lan , Liqiang Niu , Fandong Meng , Jie Zhou , Jinsong Su