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Constructing high-resolution 3D geological models from sparse 1D borehole and 2D surface data is a highly ill-posed inverse problem. Traditional heuristic and implicit modeling methods fundamentally fail to capture non-linear topological…

Computer Vision and Pattern Recognition · Computer Science 2026-04-14 Zhixiang Lu , Mengqi Han , Peixin Guo , Tianming Bai , Jionglong Su , Fei Fang , Sifan Song

The generation of accurate 3D molecular conformations is a pivotal challenge in computational chemistry and drug discovery. Recently, diffusion and flow matching models have achieved remarkable success. However, there is a critical…

Machine Learning · Computer Science 2026-05-26 Yunqing Liu , Yi Zhou , Wenqi Fan

Recent advances in imitation learning for 3D robotic manipulation have shown promising results with diffusion-based policies. However, achieving human-level dexterity requires seamless integration of geometric precision and semantic…

Advanced generative model (e.g., diffusion model) derived from simplified continuity assumptions of data distribution, though showing promising progress, has been difficult to apply directly to geometry generation applications due to the…

Chemical Physics · Physics 2024-03-26 Yuxuan Song , Jingjing Gong , Yanru Qu , Hao Zhou , Mingyue Zheng , Jingjing Liu , Wei-Ying Ma

Flow visualization technologies such as particle tracking velocimetry (PTV) are broadly used in understanding the all-pervasiveness three-dimensional (3D) turbulent flow from nature and industrial processes. Despite the advances in 3D…

Fluid Dynamics · Physics 2022-11-01 Jiaming Liang , Chao Xu , Shengze Cai

A generative model capable of sampling realistic molecules with desired properties could accelerate chemical discovery across a wide range of applications. Toward this goal, significant effort has focused on developing models that jointly…

Machine Learning · Computer Science 2025-08-19 Ian Dunn , David R. Koes

Computational fluid dynamics (CFD) provides high-fidelity simulations of fluid flows but remains computationally expensive for many-query applications. In recent years deep learning (DL) has been used to construct data-driven fluid-dynamic…

Machine Learning · Computer Science 2026-04-13 David Ramos , Lucas Lacasa , Fermín Gutiérrez , Eusebio Valero , Gonzalo Rubio

Understanding and predicting object motion from egocentric video is fundamental to embodied perception and interaction. However, generating physically consistent 6DoF trajectories remains challenging due to occlusions, fast motion, and the…

Computer Vision and Pattern Recognition · Computer Science 2026-04-03 Abhishek Saroha , Huajian Zeng , Xingxing Zuo , Daniel Cremers , Xi Wang

Physics-constrained generative modeling aims to produce high-dimensional samples that are both physically consistent and distributionally accurate, a task that remains challenging due to often conflicting optimization objectives. Recent…

Machine Learning · Computer Science 2026-02-24 Giacomo Baldan , Qiang Liu , Alberto Guardone , Nils Thuerey

Deep generative models provide a promising approach to de novo 3D peptide design. Most of them jointly model the distributions of peptide's position, orientation, and conformation, attempting to simultaneously converge to the target pocket.…

Quantitative Methods · Quantitative Biology 2025-11-04 Dengdeng Huang , Shikui Tu

3D scene generation is a core technology for gaming, film/VFX, and VR/AR. Growing demand for rapid iteration, high-fidelity detail, and accessible content creation has further increased interest in this area. Existing methods broadly follow…

Computer Vision and Pattern Recognition · Computer Science 2026-01-29 Haozhi Zhu , Miaomiao Zhao , Dingyao Liu , Runze Tian , Yan Zhang , Jie Guo , Fenggen Yu

Generative inverse design requires incorporating physical constraints to ensure that generated designs are both reliable and accurate. However, we observe that current state-of-the-art energy-based methods suffer from an asynchronous…

Computational Engineering, Finance, and Science · Computer Science 2025-12-10 Aobo Yang , Zhen Wei , Rhea Liem , Pascal Fua

Molecular structure generation is a fundamental problem that involves determining the 3D positions of molecules' constituents. It has crucial biological applications, such as molecular docking, protein folding, and molecular design. Recent…

Machine Learning · Computer Science 2025-08-27 Wenyin Zhou , Christopher Iliffe Sprague , Vsevolod Viliuga , Matteo Tadiello , Arne Elofsson , Hossein Azizpour

Accurate emulation of multi-scale physical systems governed by PDEs demands models that remain stable over long autoregressive rollouts while preserving fine-scale structures. Deterministic emulators produce overly-smoothed predictions,…

Inverse problems governed by partial differential equations (PDEs) are crucial in science and engineering. They are particularly challenging due to ill-posedness, data sparsity, and the added complexity of irregular geometries. Classical…

Machine Learning · Computer Science 2025-09-30 Sifan Wang , Zhikai Wu , David van Dijk , Lu Lu

Unbounded 3D world generation is emerging as a foundational task for scene modeling in computer vision, graphics, and robotics. In this work, we present WorldFlow3D, a novel method capable of generating unbounded 3D worlds. Building upon a…

Computer Vision and Pattern Recognition · Computer Science 2026-04-01 Amogh Joshi , Julian Ost , Felix Heide

Generative models have emerged as a powerful paradigm for solving physics systems and modeling complex spatiotemporal dynamics. However, achieving high physical accuracy without incurring high computational cost remains a fundamental…

Machine Learning · Computer Science 2026-05-27 Jiahe Huang , Sihan Xu , Sharvaree Vadgama , Rose Yu

Recent advances in generative modeling -- particularly diffusion models and flow matching -- have achieved remarkable success in synthesizing discrete data such as images and videos. However, adapting these models to physical applications…

Machine Learning · Computer Science 2025-11-26 Sifan Wang , Zehao Dou , Siming Shan , Tong-Rui Liu , Lu Lu

We present two novel generative geometric deep learning frameworks, termed Flow Matching PointNet and Diffusion PointNet, for predicting fluid flow variables on irregular geometries by incorporating PointNet into flow matching and diffusion…

Computer Vision and Pattern Recognition · Computer Science 2026-01-13 Ali Kashefi

Deep generative models have recently been applied to physical systems governed by partial differential equations (PDEs), offering scalable simulation and uncertainty-aware inference. However, enforcing physical constraints, such as…

Machine Learning · Computer Science 2025-11-27 Utkarsh Utkarsh , Pengfei Cai , Alan Edelman , Rafael Gomez-Bombarelli , Christopher Vincent Rackauckas
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