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Organoids, sophisticated in vitro models of human tissues, are crucial for medical research due to their ability to simulate organ functions and assess drug responses accurately. Accurate organoid instance segmentation is critical for…

Computer Vision and Pattern Recognition · Computer Science 2026-01-13 Gui Huang , Kangyuan Zheng , Xuan Cai , Jiaqi Wang , Jianjia Zhang , Kaida Ning , Wenbo Wei , Yujuan Zhu , Jiong Zhang , Mengting Liu

Importance sampling has been successfully used to accelerate stochastic optimization in many convex problems. However, the lack of an efficient way to calculate the importance still hinders its application to Deep Learning. In this paper,…

Machine Learning · Computer Science 2017-09-14 Angelos Katharopoulos , François Fleuret

An essential problem in statistics and machine learning is the estimation of expectations involving PDFs with intractable normalizing constants. The self-normalized importance sampling (SNIS) estimator, which normalizes the IS weights, has…

Computation · Statistics 2024-07-01 Nicola Branchini , Víctor Elvira

Computing the exact likelihood of data in large Bayesian networks consisting of thousands of vertices is often a difficult task. When these models contain many deterministic conditional probability tables and when the observed values are…

Computation · Statistics 2012-06-26 Ydo Wexler , Dan Geiger

Learning neural subset selection tasks, such as compound selection in AI-aided drug discovery, have become increasingly pivotal across diverse applications. The existing methodologies in the field primarily concentrate on constructing…

Machine Learning · Computer Science 2024-06-11 Binghui Xie , Yatao Bian , Kaiwen zhou , Yongqiang Chen , Peilin Zhao , Bo Han , Wei Meng , James Cheng

The basic idea of importance sampling is to use independent samples from a proposal measure in order to approximate expectations with respect to a target measure. It is key to understand how many samples are required in order to guarantee…

Computation · Statistics 2017-01-17 S. Agapiou , O. Papaspiliopoulos , D. Sanz-Alonso , A. M. Stuart

In rare-event simulation, an importance sampling (IS) estimator is regarded as efficient if its relative error, namely the ratio between its standard deviation and mean, is sufficiently controlled. It is widely known that when a rare-event…

Statistics Theory · Mathematics 2022-10-31 Yuanlu Bai , Zhiyuan Huang , Henry Lam , Ding Zhao

Survival outcomes are common in comparative effectiveness studies and require unique handling because they are usually incompletely observed due to right-censoring. A ``once for all'' approach for causal inference with survival outcomes…

Methodology · Statistics 2021-12-21 Shuxi Zeng , Fan Li , Liangyuan Hu , Fan Li

Multiple importance sampling (MIS) is an increasingly used methodology where several proposal densities are used to approximate integrals, generally involving target probability density functions. The use of several proposals allows for a…

Statistics Theory · Mathematics 2022-07-12 Rahul Mukerjee , Víctor Elvira

Ensembling is now recognized as an effective approach for increasing the predictive performance and calibration of deep networks. We introduce a new approach, Parameter Ensembling by Perturbation (PEP), that constructs an ensemble of…

Machine Learning · Computer Science 2020-10-27 Alireza Mehrtash , Purang Abolmaesumi , Polina Golland , Tina Kapur , Demian Wassermann , William M. Wells

Meta-learning aims to learn general knowledge with diverse training tasks conducted from limited data, and then transfer it to new tasks. It is commonly believed that increasing task diversity will enhance the generalization ability of…

Machine Learning · Computer Science 2024-06-04 Jingyao Wang , Wenwen Qiang , Xingzhe Su , Changwen Zheng , Fuchun Sun , Hui Xiong

The marginal likelihood is a central tool for drawing Bayesian inference about the number of components in mixture models. It is often approximated since the exact form is unavailable. A bias in the approximation may be due to an incomplete…

Computation · Statistics 2014-11-14 Jeong Eun Lee , Christian P. Robert

The estimation of normalizing constants is a fundamental step in probabilistic model comparison. Sequential Monte Carlo methods may be used for this task and have the advantage of being inherently parallelizable. However, the standard…

Machine Learning · Statistics 2016-08-16 Marco Fraccaro , Ulrich Paquet , Ole Winther

Standard Importance Sampling (IS) collapses under label corruption because high-norm examples, prioritized for variance reduction, are often adversarial outliers. We formalize this misalignment using an $\varepsilon$-contamination model and…

Machine Learning · Computer Science 2026-05-11 Csongor Horváth , Ida-Maria Sintorn , Prashant Singh

Importance sampling is a widely used technique to estimate properties of a distribution. This paper investigates trading-off some bias for variance by adaptively winsorizing the importance sampling estimator. The novel winsorizing…

Computation · Statistics 2021-02-10 Paulo Orenstein

Piecewise deterministic Markov processes (PDMPs) can be used to model complex dynamical industrial systems. The counterpart of this modeling capability is their simulation cost, which makes reliability assessment untractable with standard…

Computation · Statistics 2023-06-08 Guillaume Chennetier , Hassane Chraibi , Anne Dutfoy , Josselin Garnier

The practice of pooling several individual test statistics to form aggregate tests is common in many statistical application where individual tests may be underpowered. While selection by aggregate tests can serve to increase power, the…

Methodology · Statistics 2020-12-08 Ruth Heller , Amit Meir , Nilanjan Chatterjee

Importance sampling is widely used to improve the efficiency of deep neural network (DNN) training by reducing the variance of gradient estimators. However, efficiently assessing the variance reduction relative to uniform sampling remains…

Machine Learning · Computer Science 2025-11-19 Takuro Kutsuna

The goal of this paper is to develop provably efficient importance sampling Monte Carlo methods for the estimation of rare events within the class of linear stochastic partial differential equations (SPDEs). We find that if a spectral gap…

Probability · Mathematics 2017-05-05 Michael Salins , Konstantinos Spiliopoulos

The use of propensity score (PS) methods has become ubiquitous in causal inference. At the heart of these methods is the positivity assumption. Violation of the positivity assumption leads to the presence of extreme PS weights when…

Methodology · Statistics 2024-05-21 Yi Liu , Huiyue Li , Yunji Zhou , Roland Matsouaka