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Large Language Models (LLMs) have demonstrated significant potential in medical Question Answering (QA), yet they remain prone to hallucinations and ungrounded reasoning, limiting their reliability in high-stakes clinical scenarios. While…

Information Retrieval · Computer Science 2026-01-09 Jessica Ryan , Alexander I. Gumilang , Robert Wiliam , Derwin Suhartono

This paper presents the development and evaluation of a Retrieval-Augmented Generation (RAG) system for querying the United Kingdom's National Institute for Health and Care Excellence (NICE) clinical guidelines using Large Language Models…

Summarization of electronic health records (EHRs) can substantially minimize 'screen time' for both patients as well as medical personnel. In recent years summarization of EHRs have employed machine learning pipelines using state of the art…

Computation and Language · Computer Science 2024-01-04 Walid Saba , Suzanne Wendelken , James. Shanahan

The vast amount of biomedical information available today presents a significant challenge for investigators seeking to digest, process, and understand these findings effectively. Large Language Models (LLMs) have emerged as powerful tools…

Computation and Language · Computer Science 2024-07-19 Alexander R. Pelletier , Joseph Ramirez , Irsyad Adam , Simha Sankar , Yu Yan , Ding Wang , Dylan Steinecke , Wei Wang , Peipei Ping

Despite the recent advancement in Retrieval-Augmented Generation (RAG) systems, most retrieval methodologies are often developed for factual retrieval, which assumes query and positive documents are semantically similar. In this paper, we…

Information Retrieval · Computer Science 2025-04-10 Luo Ji , Feixiang Guo , Teng Chen , Qingqing Gu , Xiaoyu Wang , Ningyuan Xi , Yihong Wang , Peng Yu , Yue Zhao , Hongyang Lei , Zhonglin Jiang , Yong Chen

Objective: Applying large language models (LLMs) to the clinical domain is challenging due to the context-heavy nature of processing medical records. Retrieval-augmented generation (RAG) offers a solution by facilitating reasoning over…

Computation and Language · Computer Science 2025-08-21 Skatje Myers , Timothy A. Miller , Yanjun Gao , Matthew M. Churpek , Anoop Mayampurath , Dmitriy Dligach , Majid Afshar

Large language models (LLMs) are transforming the landscape of medicine, yet two fundamental challenges persist: keeping up with rapidly evolving medical knowledge and providing verifiable, evidence-grounded reasoning. Retrieval-augmented…

Large Language Models (LLMs) have swiftly emerged as vital resources for different applications in the biomedical and healthcare domains; however, these models encounter issues such as generating inaccurate information or hallucinations.…

Computation and Language · Computer Science 2024-05-06 Mingchen Li , Halil Kilicoglu , Hua Xu , Rui Zhang

This study presents a novel framework for smart search in digital archival systems, leveraging the capabilities of Large Language Models (LLMs) to enhance information retrieval. By employing a Retrieval-Augmented Generation (RAG) approach,…

Artificial Intelligence · Computer Science 2025-01-14 Ha Dung Nguyen , Thi-Hoang Anh Nguyen , Thanh Binh Nguyen

Retrieval-Augmented Generation (RAG) merges retrieval methods with deep learning advancements to address the static limitations of large language models (LLMs) by enabling the dynamic integration of up-to-date external information. This…

Information Retrieval · Computer Science 2026-05-19 Yizheng Huang , Jimmy Huang

Large Language Models (LLMs) have shown promising performance on diverse medical benchmarks, highlighting their potential in supporting real-world clinical tasks. Retrieval-Augmented Generation (RAG) has emerged as a key approach for…

Computation and Language · Computer Science 2025-09-30 Kaishuai Xu , Wenjun Hou , Yi Cheng , Wenjie Li

Retrieving information from EHR systems is essential for answering specific questions about patient journeys and improving the delivery of clinical care. Despite this fact, most EHR systems still rely on keyword-based searches. With the…

Computation and Language · Computer Science 2024-04-11 Shashi Kant Gupta , Aditya Basu , Bradley Taylor , Anai Kothari , Hrituraj Singh

Large Language Models (LLMs), although powerful in general domains, often perform poorly on domain-specific tasks such as medical question answering (QA). In addition, LLMs tend to function as "black-boxes", making it challenging to modify…

Computation and Language · Computer Science 2024-08-19 Yucheng Shi , Shaochen Xu , Tianze Yang , Zhengliang Liu , Tianming Liu , Quanzheng Li , Xiang Li , Ninghao Liu

Large Language Models (LLMs) have shown remarkable capabilities in general domains but often struggle with tasks requiring specialized knowledge. Conventional Retrieval-Augmented Generation (RAG) techniques typically retrieve external…

Computation and Language · Computer Science 2025-02-20 Yucheng Shi , Tianze Yang , Canyu Chen , Quanzheng Li , Tianming Liu , Xiang Li , Ninghao Liu

This paper presents CaseGPT, an innovative approach that combines Large Language Models (LLMs) and Retrieval-Augmented Generation (RAG) technology to enhance case-based reasoning in the healthcare and legal sectors. The system addresses the…

Information Retrieval · Computer Science 2024-07-12 Rui Yang

Verifiable generation aims to let the large language model (LLM) generate text with supporting documents, which enables the user to flexibly verify the answer and makes the LLM's output more reliable. Retrieval plays a crucial role in…

Computation and Language · Computer Science 2024-03-28 Xiaonan Li , Changtai Zhu , Linyang Li , Zhangyue Yin , Tianxiang Sun , Xipeng Qiu

Large Language Models (LLMs) have been integrated into recommender systems to enhance user behavior comprehension. The Retrieval Augmented Generation (RAG) technique is further incorporated into these systems to retrieve more relevant items…

Information Retrieval · Computer Science 2025-03-27 Sichun Luo , Jian Xu , Xiaojie Zhang , Linrong Wang , Sicong Liu , Hanxu Hou , Linqi Song

Large Language Models (LLMs) play powerful, black-box readers in the retrieve-then-read pipeline, making remarkable progress in knowledge-intensive tasks. This work introduces a new framework, Rewrite-Retrieve-Read instead of the previous…

Computation and Language · Computer Science 2023-10-24 Xinbei Ma , Yeyun Gong , Pengcheng He , Hai Zhao , Nan Duan

The extraction of critical patient information from Electronic Health Records (EHRs) poses significant challenges due to the complexity and unstructured nature of the data. Traditional machine learning approaches often fail to capture…

Computation and Language · Computer Science 2025-09-03 Zhimeng Luo , Abhibha Gupta , Adam Frisch , Daqing He

Large language models (LLMs) in biomedicine face a fundamental conflict between static parameter knowledge and the dynamic nature of clinical evidence. Retrieval-Augmented Generation (RAG) addresses this by grounding generation in external…

Other Quantitative Biology · Quantitative Biology 2025-12-19 Jiawei He , Boya Zhang , Hossein Rouhizadeh , Yingjian Chen , Rui Yang , Jin Lu , Xudong Chen , Nan Liu , Douglas Teodoro