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Diffusion generative models have emerged as a powerful framework for addressing problems in structural biology and structure-based drug design. These models operate directly on 3D molecular structures. Due to the unfavorable scaling of…

Biomolecules · Quantitative Biology 2024-05-10 Ian Dunn , David Ryan Koes

Generative diffusion models showed high success in many fields with a powerful theoretical background. They convert the data distribution to noise and remove the noise back to obtain a similar distribution. Many existing reviews focused on…

Machine Learning · Computer Science 2024-09-19 Melike Nur Yeğin , Mehmet Fatih Amasyalı

Diffusion models are at the vanguard of generative AI research with renowned solutions such as ImageGen by Google Brain and DALL.E 3 by OpenAI. Nevertheless, the potential merits of diffusion models for communication engineering…

Information Theory · Computer Science 2023-11-17 Mehdi Letafati , Samad Ali , Matti Latva-aho

Score-based models generate samples by mapping noise to data (and vice versa) via a high-dimensional diffusion process. We question whether it is necessary to run this entire process at high dimensionality and incur all the inconveniences…

Machine Learning · Computer Science 2023-02-28 Bowen Jing , Gabriele Corso , Renato Berlinghieri , Tommi Jaakkola

Molecular conformation generation, a critical aspect of computational chemistry, involves producing the three-dimensional conformer geometry for a given molecule. Generating molecular conformation via diffusion requires learning to reverse…

Computational Physics · Physics 2023-10-10 Zihan Zhou , Ruiying Liu , Chaolong Ying , Ruimao Zhang , Tianshu Yu

Accurately predicting 3D occupancy grids from visual inputs is critical for autonomous driving, but current discriminative methods struggle with noisy data, incomplete observations, and the complex structures inherent in 3D scenes. In this…

Computer Vision and Pattern Recognition · Computer Science 2025-07-04 Yunshen Wang , Yicheng Liu , Tianyuan Yuan , Yingshi Liang , Xiuyu Yang , Honggang Zhang , Hang Zhao

The emergence of billion-parameter diffusion models such as Stable Diffusion XL, Imagen, and DALL-E 3 has significantly propelled the domain of generative AI. However, their large-scale architecture presents challenges in fine-tuning and…

Computer Vision and Pattern Recognition · Computer Science 2024-07-19 Hyogon Ryu , Seohyun Lim , Hyunjung Shim

We present an investigation into diffusion models for molecular generation, with the aim of better understanding how their predictions compare to the results of physics-based calculations. The investigation into these models is driven by…

Embodied agents operate in a structured world, often solving tasks with spatial, temporal, and permutation symmetries. Most algorithms for planning and model-based reinforcement learning (MBRL) do not take this rich geometric structure into…

Machine Learning · Computer Science 2023-10-20 Johann Brehmer , Joey Bose , Pim de Haan , Taco Cohen

Molecular conformation generation plays key roles in computational drug design. Recently developed deep learning methods, particularly diffusion models have reached competitive performance over traditional cheminformatical approaches.…

Machine Learning · Computer Science 2025-01-10 Yixuan Yang , Xingyu Fang , Zhaowen Cheng , Pengju Yan , Xiaolin Li

The flow matching has rapidly become a dominant paradigm in classical generative modeling, offering an efficient way to interpolate between two complex distributions. We extend this idea to the quantum realm and introduce the Quantum Flow…

Quantum Physics · Physics 2026-02-03 Zidong Cui , Pan Zhang , Ying Tang

Modeling the time-dependent evolution of electron density is essential for understanding quantum mechanical behaviors of condensed matter and enabling predictive simulations in spectroscopy, photochemistry, and ultrafast science. Yet, while…

Computational Physics · Physics 2025-09-03 Yuan Chiang , Youngsoo Choi , Daniel Osei-Kuffuor

Diffusion models offer stable training and state-of-the-art performance for deep generative modeling tasks. Here, we consider their use in the context of multivariate subsurface modeling and probabilistic inversion. We first demonstrate…

Computer Vision and Pattern Recognition · Computer Science 2026-01-28 Roberto Miele , Niklas Linde

Diffusion and flow-based models have become the state of the art for generative AI across a wide range of data modalities, including images, videos, shapes, molecules, music, and more. This tutorial provides a self-contained introduction to…

Machine Learning · Computer Science 2026-03-19 Peter Holderrieth , Ezra Erives

Generative models, such as GANs and diffusion models, have been used to augment training sets and boost performances in different tasks. We focus on generative models for cell detection instead, i.e., locating and classifying cells in given…

Computer Vision and Pattern Recognition · Computer Science 2024-09-06 Chen Li , Xiaoling Hu , Shahira Abousamra , Meilong Xu , Chao Chen

We present a generative modeling framework for atomistic systems that combines score-based diffusion for atomic positions with a novel continuous-time discrete diffusion process for atomic types. This approach enables flexible and…

Computational Physics · Physics 2025-09-17 Nikolaj Rønne , Bjørk Hammer

Denoising diffusion models have proven to be a flexible and effective paradigm for generative modelling. Their recent extension to infinite dimensional Euclidean spaces has allowed for the modelling of stochastic processes. However, many…

Diffusion models have emerged as a powerful framework for generative tasks in deep learning. They decompose generative modeling into two computational primitives: deterministic neural-network evaluation and stochastic sampling. Current…

Machine Learning · Computer Science 2026-03-31 Nihal Sanjay Singh , Mazdak Mohseni-Rajaee , Shaila Niazi , Kerem Y. Camsari

This paper explores image modeling from the frequency space and introduces DCTdiff, an end-to-end diffusion generative paradigm that efficiently models images in the discrete cosine transform (DCT) space. We investigate the design space of…

Computer Vision and Pattern Recognition · Computer Science 2025-06-02 Mang Ning , Mingxiao Li , Jianlin Su , Haozhe Jia , Lanmiao Liu , Martin Beneš , Wenshuo Chen , Albert Ali Salah , Itir Onal Ertugrul

Diffusion models have emerged as powerful tools for molecular generation, particularly in the context of 3D molecular structures. Inspired by non-equilibrium statistical physics, these models can generate 3D molecular structures with…

Chemical Physics · Physics 2025-05-16 Amira Alakhdar , Barnabas Poczos , Newell Washburn