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Genomic language models (gLMs) have shown mostly modest success in identifying evolutionarily constrained elements in mammalian genomes. To address this issue, we introduce a novel framework for training gLMs that explicitly models…

Genomics · Quantitative Biology 2026-03-23 Carlos Albors , Jianan Canal Li , Gonzalo Benegas , Chengzhong Ye , Yun S. Song

Interpretability of deep learning is widely used to evaluate the reliability of medical imaging models and reduce the risks of inaccurate patient recommendations. For models exceeding human performance, e.g. predicting RNA structure from…

Quantitative Methods · Quantitative Biology 2022-08-31 Mara Graziani , Niccolò Marini , Nicolas Deutschmann , Nikita Janakarajan , Henning Müller , María Rodríguez Martínez

Language models (LM) have grown with non-stop in the last decade, from sequence-to-sequence architectures to the state-of-the-art and utter attention-based Transformers. In this work, we demonstrate how the inclusion of deep generative…

Computation and Language · Computer Science 2021-08-25 Aurora Cobo Aguilera , Pablo Martínez Olmos , Antonio Artés-Rodríguez , Fernando Pérez-Cruz

While current state-of-the-art NMT models, such as RNN seq2seq and Transformers, possess a large number of parameters, they are still shallow in comparison to convolutional models used for both text and vision applications. In this work we…

Computation and Language · Computer Science 2018-09-06 Ankur Bapna , Mia Xu Chen , Orhan Firat , Yuan Cao , Yonghui Wu

Text classification is a fundamental task in natural language processing (NLP). Several recent studies show the success of deep learning on text processing. Convolutional neural network (CNN), as a popular deep learning model, has shown…

Computation and Language · Computer Science 2023-01-30 Ali Jarrahi , Ramin Mousa , Leila Safari

Accurate molecular property prediction is a critical challenge with wide-ranging applications in chemistry, materials science, and drug discovery. Molecular representation methods, including fingerprints and graph neural networks (GNNs),…

Machine Learning · Computer Science 2025-08-13 Jiaxin Ju , Yizhen Zheng , Huan Yee Koh , Can Wang , Shirui Pan

Large Language Models (LLMs) have achieved remarkable success in natural language tasks, yet understanding their reasoning processes remains a significant challenge. We address this by introducing XplainLLM, a dataset accompanying an…

Computation and Language · Computer Science 2024-09-24 Zichen Chen , Jianda Chen , Ambuj Singh , Misha Sra

The integration of multi-omic data is pivotal for understanding complex diseases, but its high dimensionality and noise present significant challenges. Graph Neural Networks (GNNs) offer a robust framework for analyzing large-scale…

Quantitative Methods · Quantitative Biology 2024-12-23 Heming Zhang , Di Huang , Yixin Chen , Fuhai Li

Understanding covert narratives and implicit messaging is essential for analyzing bias and sentiment. Traditional NLP methods struggle with detecting subtle phrasing and hidden agendas. This study tackles two key challenges: (1) multi-label…

Computation and Language · Computer Science 2025-09-05 Rishit Tyagi , Rahul Bouri , Mohit Gupta

The emergence of large-scale pre-trained language models has revolutionized various AI research domains. Transformers-based Large Language Models (LLMs) have gradually replaced CNNs and RNNs to unify fields of computer vision and natural…

Computation and Language · Computer Science 2024-02-07 Ruosong Ye , Caiqi Zhang , Runhui Wang , Shuyuan Xu , Yongfeng Zhang

This study presents a hybrid deep learning architecture that integrates LSTM, CNN, and an Attention mechanism to enhance the classification of web content based on text. Pretrained GloVe embeddings are used to represent words as dense…

Computation and Language · Computer Science 2025-12-29 Mykola Kuz , Ihor Lazarovych , Mykola Kozlenko , Mykola Pikuliak , Andrii Kvasniuk

Pretrained language models (PLMs) have produced substantial improvements in discourse-aware neural machine translation (NMT), for example, improved coherence in spoken language translation. However, the underlying reasons for their strong…

Computation and Language · Computer Science 2023-06-01 Zhihong Huang , Longyue Wang , Siyou Liu , Derek F. Wong

Objective: Clinical deep phenotyping and phenotype annotation play a critical role in both the diagnosis of patients with rare disorders as well as in building computationally-tractable knowledge in the rare disorders field. These processes…

Interpretable graph neural networks (XGNNs ) are widely adopted in various scientific applications involving graph-structured data. Existing XGNNs predominantly adopt the attention-based mechanism to learn edge or node importance for…

Machine Learning · Computer Science 2024-06-13 Yongqiang Chen , Yatao Bian , Bo Han , James Cheng

Recent advances in interpretability suggest we can project weights and hidden states of transformer-based language models (LMs) to their vocabulary, a transformation that makes them more human interpretable. In this paper, we investigate LM…

Computation and Language · Computer Science 2023-11-27 Shahar Katz , Yonatan Belinkov

When reading temporarily ambiguous garden-path sentences, misinterpretations sometimes linger past the point of disambiguation. This phenomenon has traditionally been studied in psycholinguistic experiments using online measures such as…

Computation and Language · Computer Science 2024-05-28 Andrew Li , Xianle Feng , Siddhant Narang , Austin Peng , Tianle Cai , Raj Sanjay Shah , Sashank Varma

Contemporary neural networks have achieved a series of developments and successes in many aspects; however, when exposed to data outside the training distribution, they may fail to predict correct answers. In this work, we were concerned…

Computation and Language · Computer Science 2022-03-22 Wanshui Li , Pasquale Minervini

Explainable Artificial Intelligence has gained significant attention due to the widespread use of complex deep learning models in high-stake domains such as medicine, finance, and autonomous cars. However, different explanations often…

Artificial Intelligence · Computer Science 2024-04-17 Weronika Hryniewska-Guzik , Luca Longo , Przemysław Biecek

Molecular property prediction is a crucial foundation for drug discovery. In recent years, pre-trained deep learning models have been widely applied to this task. Some approaches that incorporate prior biological domain knowledge into the…

Machine Learning · Computer Science 2024-08-20 Tianyu Zhang , Yuxiang Ren , Chengbin Hou , Hairong Lv , Xuegong Zhang

Lack of explainability in artificial intelligence, specifically deep neural networks, remains a bottleneck for implementing models in practice. Popular techniques such as Gradient-weighted Class Activation Mapping (Grad-CAM) provide a…

Computer Vision and Pattern Recognition · Computer Science 2021-11-03 Amil Dravid , Aggelos K. Katsaggelos
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