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Mutation analysis assesses a test suite's adequacy by measuring its ability to detect small artificial faults, systematically seeded into the tested program. Mutation analysis is considered one of the strongest test-adequacy criteria.…

Software Engineering · Computer Science 2021-03-01 Goran Petrović , Marko Ivanković , Gordon Fraser , René Just

Multivariate meta-analysis is gaining prominence in evidence synthesis research because it enables simultaneous synthesis of multiple correlated outcome data, and random-effects models have generally been used for addressing between-studies…

Methodology · Statistics 2021-07-14 Hisashi Noma , Kengo Nagashima , Toshi A. Furukawa

Genomic signal processing has been used successfully in bioinformatics to analyze biomolecular sequences and gain varied insights into DNA structure, gene organization, protein binding, sequence evolution, etc. But challenges remain in…

Genomics · Quantitative Biology 2022-11-04 Saish Jaiswal , Shreya Nema , Hema A Murthy , Manikandan Narayanan

Mutation testing is a powerful technique for assessing and improving test suite quality that artificially introduces bugs and checks whether the test suites catch them. However, it is also computationally expensive and thus does not scale…

Software Engineering · Computer Science 2023-09-06 Kush Jain , Uri Alon , Alex Groce , Claire Le Goues

In the genomic era, the identification of gene signatures associated with disease is of significant interest. Such signatures are often used to predict clinical outcomes in new patients and aid clinical decision-making. However, recent…

Methodology · Statistics 2019-03-27 Naim U. Rashid , Quefeng Li , Jen Jen Yeh , Joseph G. Ibrahim

The expected signature maps a collection of data streams to a lower dimensional representation, with a remarkable property: the resulting feature tensor can fully characterize the data generating distribution. This "model-free" embedding…

Machine Learning · Statistics 2025-05-29 Lorenzo Lucchese , Mikko S. Pakkanen , Almut E. D. Veraart

Mutation is one of the most important stages of the genetic algorithm because of its impact on the exploration of global optima, and to overcome premature convergence. There are many types of mutation, and the problem lies in selection of…

Amino-acid substitutions are implicated in a wide range of human diseases, many of which are lethal. Distinguishing such mutations from polymorphisms without significant effect on human health is a necessary step in understanding the…

Quantitative Methods · Quantitative Biology 2017-01-26 Christoph Feinauer , Martin Weigt

Text matching is a fundamental technique in both information retrieval and natural language processing. Text matching tasks share the same paradigm that determines the relationship between two given texts. The relationships vary from task…

Information Retrieval · Computer Science 2022-08-23 Shicheng Xu , Liang Pang , Huawei Shen , Xueqi Cheng

Many finance, physics, and engineering phenomena are modeled by continuous-time dynamical systems driven by highly irregular (stochastic) inputs. A powerful tool to perform time series analysis in this context is rooted in rough path theory…

Machine Learning · Computer Science 2023-04-27 Enea Monzio Compagnoni , Anna Scampicchio , Luca Biggio , Antonio Orvieto , Thomas Hofmann , Josef Teichmann

We present a deep generative model of bilingual sentence pairs for machine translation. The model generates source and target sentences jointly from a shared latent representation and is parameterised by neural networks. We perform…

Computation and Language · Computer Science 2019-06-03 Bryan Eikema , Wilker Aziz

All scientific interpretations of statistical outputs depend on background (auxiliary) assumptions that are rarely delineated or explicitly interrogated. These include not only the usual modeling assumptions, but also deeper assumptions…

Methodology · Statistics 2022-08-01 Sander Greenland , Zad Rafi , Robert Matthews , Megan Higgs

We introduce a framework for uncertainty estimation that both describes and extends many existing methods. We consider typical hyperparameters involved in classical training as random variables and marginalise them out to capture various…

Machine Learning · Computer Science 2021-07-07 Francesco Farina , Lawrence Phillips , Nicola J Richmond

The accuracy of predictive models for solitary pulmonary nodule (SPN) diagnosis can be greatly increased by incorporating repeat imaging and medical context, such as electronic health records (EHRs). However, clinically routine modalities…

Mixed-effect models are flexible tools for researchers in a myriad of fields, but that flexibility comes at the cost of complexity and if users are not careful in how their model is specified, they could be making faulty inferences from…

Methodology · Statistics 2023-08-28 Keith R. Lohse , Allan J. Kozlowski , Michael J. Strube

We study the expansions of permutation statistics in the basis of functions counting occurrences of a fixed pattern in a permutation. We show the finiteness of these pattern expansions for a class of permutation statistics including the…

Combinatorics · Mathematics 2026-01-08 Ian Cavey , Hugh Dennin , Bridget Eileen Tenner

For optimization models to be used in practice, it is crucial that users trust the results. A key factor in this aspect is the interpretability of the solution process. A previous framework for inherently interpretable optimization models…

Optimization and Control · Mathematics 2026-02-13 Marc Goerigk , Michael Hartisch , Sebastian Merten , Kartikey Sharma

Probabilistic programming has emerged as a powerful paradigm in statistics, applied science, and machine learning: by decoupling modelling from inference, it promises to allow modellers to directly reason about the processes generating…

Machine Learning · Statistics 2019-06-10 Maria I. Gorinova , Dave Moore , Matthew D. Hoffman

As machine learning models are increasingly considered for high-stakes domains, effective explanation methods are crucial to ensure that their prediction strategies are transparent to the user. Over the years, numerous metrics have been…

Machine Learning · Computer Science 2025-04-14 Johannes Maeß , Grégoire Montavon , Shinichi Nakajima , Klaus-Robert Müller , Thomas Schnake

Predictive constructions are a powerful way of characterizing the probability law of stochastic processes with certain forms of invariance, such as exchangeability or Markov exchangeability. When de Finetti-like representation theorems are…

Methodology · Statistics 2015-11-16 Sandra Fortini , Sonia Petrone
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