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Reliable estimation of feature contributions in machine learning models is essential for trust, transparency and regulatory compliance, especially when models are proprietary or otherwise operate as black boxes. While permutation-based…

Machine Learning · Statistics 2025-12-24 Albert Dorador

The signature transform is a 'universal nonlinearity' on the space of continuous vector-valued paths, and has received attention for use in machine learning on time series. However, real-world temporal data is typically observed at discrete…

Machine Learning · Computer Science 2020-06-09 Michael Moor , Max Horn , Christian Bock , Karsten Borgwardt , Bastian Rieck

Mutation analysis measures test suite adequacy, the degree to which a test suite detects seeded faults: one test suite is better than another if it detects more mutants. Mutation analysis effectiveness rests on the assumption that mutants…

Software Engineering · Computer Science 2016-11-09 Miltiadis Allamanis , Earl T. Barr , René Just , Charles Sutton

Hand-crafted mutants are increasingly used to evaluate fuzzing and property-based testing tools, but current tooling is fragmented and often forces trade-offs between readability, mutation preservation, and execution cost. We present a…

Software Engineering · Computer Science 2026-03-10 Alperen Keles

The concept of signatures and expected signatures is vital in data science, especially for sequential data analysis. The signature transform, a Cartan type development, translates paths into high-dimensional feature vectors, capturing their…

Machine Learning · Statistics 2025-05-12 Peter K. Friz , Paul P. Hager , Nikolas Tapia

Mutation analysis evaluates test suites and testing techniques by measuring how well they detect seeded defects (mutants). Even though well established in research, mutation analysis is rarely used in practice due to scalability problems…

Software Engineering · Computer Science 2013-03-13 René Just , Michael D. Ernst , Gordon Fraser

We provide an introduction to the signature method, focusing on its theoretical properties and machine learning applications. Our presentation is divided into two parts. In the first part, we present the definition and fundamental…

Machine Learning · Statistics 2025-12-29 Ilya Chevyrev , Andrey Kormilitzin

Learning meaningful causal representations from observations has emerged as a crucial task for facilitating machine learning applications and driving scientific discoveries in fields such as climate science, biology, and physics. This…

Machine Learning · Computer Science 2026-02-06 Jiaxu Ren , Yixin Wang , Biwei Huang

The appropriate choice of the genotype-phenotype mapping in combination with the mutation operator is important for a successful evolutionary search process. We suggest a measure to quantify the quality of this combination by addressing the…

adap-org · Physics 2007-05-23 Bernhard Sendhoff , Martin Kreutz , Werner von Seelen

Cancer prognosis can be regarded as estimating the risk of future outcomes from multiple variables. In prognostic signatures, these variables represent expressions of genes that are summed up to calculate a risk score. However, it is a…

This dissertation presents a multifaceted look into the structural decomposition of permutation classes. The theory of permutation patterns is a rich and varied field, and is a prime example of how an accessible and intuitive definition…

Combinatorics · Mathematics 2014-10-13 Cheyne Homberger

Motivation: ``Molecular signatures'' or ``gene-expression signatures'' are used to predict patients' characteristics using data from coexpressed genes. Signatures can enhance understanding about biological mechanisms and have diagnostic…

Quantitative Methods · Quantitative Biology 2007-05-23 Ramon Diaz-Uriarte

Various Non-negative Matrix factorization (NMF) based methods add new terms to the cost function to adapt the model to specific tasks, such as clustering, or to preserve some structural properties in the reduced space (e.g., local…

During the last decade, a large number of different numerical methods have been proposed to tackle the automatic identification and quantification in {\gamma}-ray spectrometry. However, the lack of common benchmarks, including datasets,…

Machine Learning · Computer Science 2025-08-13 Dinh Triem Phan , Jérôme Bobin , Cheick Thiam , Christophe Bobin

Revealing the functional sites of biological sequences, such as evolutionary conserved, structurally interacting or co-evolving protein sites, is a fundamental, and yet challenging task. Different frameworks and models were developed to…

Quantitative Methods · Quantitative Biology 2019-06-07 Justas Dauparas , Haobo Wang , Avi Swartz , Peter Koo , Mor Nitzan , Sergey Ovchinnikov

The signature is an infinite graded sequence of statistics known to characterise a stream of data up to a negligible equivalence class. It is a transform which has previously been treated as a fixed feature transformation, on top of which a…

Machine Learning · Computer Science 2019-10-29 Patric Bonnier , Patrick Kidger , Imanol Perez Arribas , Cristopher Salvi , Terry Lyons

RNA motifs typically consist of short, modular patterns that include base pairs formed within and between modules. Estimating the abundance of these patterns is of fundamental importance for assessing the statistical significance of matches…

Probability · Mathematics 2007-05-23 Manuel Lladser , M. D. Betterton , Rob Knight

Motivation: Most existing methods for DNA sequence analysis rely on accurate sequences or genotypes. However, in applications of the next-generation sequencing (NGS), accurate genotypes may not be easily obtained (e.g. multi-sample…

Genomics · Quantitative Biology 2013-03-19 Heng Li

Interpretability provides a means for humans to verify aspects of machine learning (ML) models and empower human+ML teaming in situations where the task cannot be fully automated. Different contexts require explanations with different…

Machine Learning · Computer Science 2024-07-15 Zixi Chen , Varshini Subhash , Marton Havasi , Weiwei Pan , Finale Doshi-Velez

Modern deep learning for asset allocation typically separates forecasting from optimization. We argue this creates a fundamental mismatch where minimizing prediction errors fails to yield robust portfolios. We propose the Signature Informed…

Machine Learning · Computer Science 2026-01-23 Yoontae Hwang , Stefan Zohren