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Growing tissue and bacterial colonies are active matter systems where cell divisions and cellular motion generate active stress. Although they operate in the non-equilibrium regime, these biological systems can form large-scale ordered…

Biological Physics · Physics 2019-05-28 Yusuf Ilker Yaman , Esin Demir , Roman Vetter , Askin Kocabas

Active nematics are the nonequilibrium analog of passive liquid crystals in which anisotropic units consume free energy to drive emergent behavior. Similar to liquid crystal (LC) molecules in displays, ordering and dynamics in active…

Quantitative Methods · Quantitative Biology 2022-10-10 Japinder Nijjer , Mrityunjay Kothari , Changhao Li , Thomas Henzel , Qiuting Zhang , Jung-Shen B. Tai , Shuang Zhou , Sulin Zhang , Tal Cohen , Jing Yan

Living active collectives have evolved with remarkable self-patterning ability to meet the physical and biological constraints for growth and survival. However, how complex multicellular patterns emerge from a single founder cell remains…

Biological Physics · Physics 2022-11-30 Changhao Li , Japinder Nijjer , Luyi Feng , Qiuting Zhang , Jing Yan , Sulin Zhang

Active matter comprised of self-propelled interacting units holds a major promise for extraction of useful work from its seemingly chaotic out-of-equilibrium dynamics. Streamlining active matter to produce work is especially important at…

Soft Condensed Matter · Physics 2021-03-17 Mojtaba Rajabi , Hend Baza , Taras Turiv , Oleg D. Lavrentovich

In growing active matter systems, a large collection of engineered or living autonomous units metabolize free energy and create order at different length scales as they proliferate and migrate collectively. One such example is bacterial…

Soft Condensed Matter · Physics 2021-06-15 Japinder Nijjer , Changhao Li , Qiuting Zhang , Haoran Lu , Sulin Zhang , Jing Yan

Natural bacterial habitats are often complex fluids with viscoelastic and anisotropic responses to stress; for example, they can take the form of liquid crystals (LCs), with elongated microscopic constituents that collectively align while…

Colloids self-assemble into various organized superstructures determined by particle interactions. There is a tremendous progress in both the scientific understanding and applications of self-assemblies of single-type identical particles.…

Soft Condensed Matter · Physics 2016-09-23 Chenhui Peng , Taras Turiv , Yubing Guo , Sergij V. Shiyanovskii , Qi-Huo Wei , Oleg D. Lavrentovich

Dynamics of small particles, both living such as swimming bacteria and inanimate, such as colloidal spheres, has fascinated scientists for centuries. If one could learn how to control and streamline their chaotic motion, that would open…

Soft Condensed Matter · Physics 2023-02-08 Oleg D. Lavrentovich

Collective behavior of bacterial colonies plays critical roles in adaptability, survivability, biofilm expansion and infection. We employ an individual-based model of an interstitial biofilm to study emergent pattern formation based on the…

Adaptation and Self-Organizing Systems · Physics 2017-02-01 Cameron Zachreson , Christian Wolff , Cynthia B. Whitchurch , Milos Toth

Non-motile elongated bacteria confined in two-dimensional open micro-channels can exhibit collective motion and form dense monolayers with nematic order if the cells proliferate, i.e., grow and divide. Using soft molecular dynamics…

Soft Condensed Matter · Physics 2013-07-25 Sirio Orozco-Fuentes , Denis Boyer

During colony growth, complex interactions regulate the bacterial orientation, leading to the formation of large-scale ordered structures, including topological defects and microdomains. These structures may benefit bacterial strains,…

Biological Physics · Physics 2024-04-10 Mustafa Başaran , Y. Ilker Yaman , Tevfik Can Yuce , Roman Vetter , Askin Kocabas

Bacterial biofilms collectively develop distinct and ordered structures, including fibers, bundles, and branches. Often, it is unclear how these structural motifs convey specific advantages to bacterial strains under challenging conditions.…

Soft Condensed Matter · Physics 2022-11-16 Mustafa Basaran , Tevfik Can Yüce , Yusuf Ilker Yaman , Roman Vetter , Askin Kocabas

Monolayers of growing bacteria, confined within channel geometries, exhibit self-organization into a highly aligned laminar state along the axis of the channel. Although this phenomenon has been observed in experiments and simulations under…

Soft Condensed Matter · Physics 2024-11-04 Blake Langeslay , Will Fahy , Gabriel Juarez

Self-propelled bacteria are marvels of nature with a potential to power dynamic materials and microsystems of the future. The challenge is in commanding their chaotic behavior. By dispersing swimming Bacillus subtilis in a…

Soft Condensed Matter · Physics 2016-12-21 Chenhui Peng , Taras Turiv , Yubing Guo , Qi-Huo Wei , Oleg D. Lavrentovich

In this fluid dynamics video we explore the nature and causes of the spontaneous ordering that emerges in a dense bacterial suspension under confinement. Recent experiments with B. Subtilis confined within small flattened drops show that…

Soft Condensed Matter · Physics 2013-10-14 Hugo Wioland , Enkeleida Lushi , Raymond E. Goldstein

Active systems comprised of self-propelled units show fascinating transitions from Brownian-like dynamics to collective coherent motion. Swirling of swimming bacteria is a spectacular example. This study demonstrates that a nematic liquid…

Bacterial colonies are a well-known example of living active matter, exhibiting collective behaviors such as nematic alignment and collective motion that play an important role in the spread of microbial infections. While the underlying…

Growing monolayers of rod-shaped bacteria exhibit local alignment similar to extensile active nematics. When confined in a channel or growing inward from a ring, the local nematic order of these monolayers changes to a global ordering with…

Soft Condensed Matter · Physics 2024-11-04 Blake Langeslay , Gabriel Juarez

In densely-packed two-dimensional systems of growing cells, such as rod-shaped bacteria, a number of experimental and numerical studies report distinct patterns of nematic orientational order in the presence of confinement. So far, these…

Soft Condensed Matter · Physics 2025-06-13 Lukas Hupe , Jonas Isensee , Ramin Golestanian , Philip Bittihn

In vivo and in vitro systems of cells and extra-cellular matrix (ECM) systems are well known to form ordered patterns of orientationally aligned fibers. Here, we interpret them as active analogs of the (disordered) isotropic to the…

Soft Condensed Matter · Physics 2025-04-11 Haiqian Yang , Ming Guo , L. Mahadevan
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