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The visual examination of tissue biopsy sections is fundamental for cancer diagnosis, with pathologists analyzing sections at multiple magnifications to discern tumor cells and their subtypes. However, existing attention-based multiple…

Computer Vision and Pattern Recognition · Computer Science 2024-10-11 Olga Fourkioti , Matt De Vries , Chen Jin , Daniel C. Alexander , Chris Bakal

Atrial Fibrillation (AF) is characterized by rapid, irregular heartbeats, and can lead to fatal complications such as heart failure. The disease is divided into two sub-types based on severity, which can be automatically classified through…

Computer Vision and Pattern Recognition · Computer Science 2023-08-15 Weihang Dai , Xiaomeng Li , Taihui Yu , Di Zhao , Jun Shen , Kwang-Ting Cheng

Weakly-supervised classification of histopathology slides is a computationally intensive task, with a typical whole slide image (WSI) containing billions of pixels to process. We propose Discriminative Region Active Sampling for Multiple…

Image and Video Processing · Electrical Eng. & Systems 2023-02-23 Jack Breen , Katie Allen , Kieran Zucker , Geoff Hall , Nicolas M. Orsi , Nishant Ravikumar

Multi-instance learning (MIL) is an effective paradigm for whole-slide pathological images (WSIs) classification to handle the gigapixel resolution and slide-level label. Prevailing MIL methods primarily focus on improving the feature…

Computer Vision and Pattern Recognition · Computer Science 2023-03-14 Tiancheng Lin , Zhimiao Yu , Hongyu Hu , Yi Xu , Chang Wen Chen

Classical multiple instance learning (MIL) methods are often based on the identical and independent distributed assumption between instances, hence neglecting the potentially rich contextual information beyond individual entities. On the…

Computer Vision and Pattern Recognition · Computer Science 2022-06-20 Daniel Reisenbüchler , Sophia J. Wagner , Melanie Boxberg , Tingying Peng

Predicting breast cancer recurrence risk is a critical clinical challenge. This study investigates the potential of computational pathology to stratify patients using deep learning on routine Hematoxylin and Eosin (H&E) stained whole-slide…

Computer Vision and Pattern Recognition · Computer Science 2025-12-23 Jinqiu Chen , Huyan Xu

Deep learning based computer vision fails to work when labeled images are scarce. Recently, Meta learning algorithm has been confirmed as a promising way to improve the ability of learning from few images for computer vision. However,…

Machine Learning · Computer Science 2018-11-27 Yunxiao Qin , Chenxu Zhao , Zezheng Wang , Junliang Xing , Jun Wan , Zhen Lei

Lung adenocarcinoma (LUAD) is characterized by substantial genetic heterogeneity, posing challenges in identifying reliable biomarkers for improved diagnosis and treatment. Tumor Mutational Burden (TMB) has traditionally been regarded as a…

Applications · Statistics 2024-11-08 Shaofei Zhao , Siming Huang , Kexuan Li , Weiyu Zhou , Lingli Yang , Shige Wang

Various multi-instance learning (MIL) based approaches have been developed and successfully applied to whole-slide pathological images (WSI). Existing MIL methods emphasize the importance of feature aggregators, but largely neglect the…

Computer Vision and Pattern Recognition · Computer Science 2025-05-13 Yicheng Song , Tiancheng Lin , Die Peng , Su Yang , Yi Xu

Masked diffusion language models (MDLMs) enable parallel decoding by predicting all masked positions at each denoising step, yet existing training-free samplers usually decide which positions to commit at token-level granularity. We revisit…

Machine Learning · Computer Science 2026-05-29 Heqiang Qi , Wei Huang , Mingyuan Bai , Xiangming Meng

Dense prediction models are widely used for image segmentation. One important challenge is to sufficiently train these models to yield good generalizations for hard-to-learn pixels. A typical group of such hard-to-learn pixels are…

Computer Vision and Pattern Recognition · Computer Science 2019-08-07 Gozde Nur Gunesli , Cenk Sokmensuer , Cigdem Gunduz-Demir

Multimodal learning, integrating histology images and genomics, promises to enhance precision oncology with comprehensive views at microscopic and molecular levels. However, existing methods may not sufficiently model the shared or…

Computer Vision and Pattern Recognition · Computer Science 2024-06-12 Huahui Yi , Xiaofei Wang , Kang Li , Chao Li

Multiple Instance Learning (MIL) has been widely applied in pathology towards solving critical problems such as automating cancer diagnosis and grading, predicting patient prognosis, and therapy response. Deploying these models in a…

Computer Vision and Pattern Recognition · Computer Science 2022-10-18 Syed Ashar Javed , Dinkar Juyal , Harshith Padigela , Amaro Taylor-Weiner , Limin Yu , Aaditya Prakash

Advancements in deep learning are driven by training models with increasingly larger numbers of parameters, which in turn heightens the computational demands. To address this issue, Mixture-of-Depths (MoD) models have been proposed to…

Computer Vision and Pattern Recognition · Computer Science 2024-12-31 Advait Gadhikar , Souptik Kumar Majumdar , Niclas Popp , Piyapat Saranrittichai , Martin Rapp , Lukas Schott

Current deep learning based text classification methods are limited by their ability to achieve fast learning and generalization when the data is scarce. We address this problem by integrating a meta-learning procedure that uses the…

Quantum machine learning offers a promising new paradigm for computational biology by leveraging quantum mechanical principles to enhance cancer classification, biomarker discovery, and bioinformatics diagnostics. In this study, we apply…

Genomics · Quantitative Biology 2026-04-22 Mandeep Kaur Saggi , Amandeep Singh Bhatia , Humaira Gowher , Sabre Kais

Bag-based Multiple Instance Learning (MIL) approaches have emerged as the mainstream methodology for Whole Slide Image (WSI) classification. However, most existing methods adopt a segmented training strategy, which first extracts features…

Computer Vision and Pattern Recognition · Computer Science 2025-03-13 Jiangping Wen , Jinyu Wen , Meie Fang

Learning robust representations for physiological time-series signals continues to pose a substantial challenge in developing efficient few-shot learning applications. This difficulty is largely due to the complex pathological variations in…

Machine Learning · Computer Science 2025-12-01 Rami Zewail

Automated interpretation of ultrasound imaging of the heart (echocardiograms) could improve the detection and treatment of aortic stenosis (AS), a deadly heart disease. However, existing deep learning pipelines for assessing AS from…

Computer Vision and Pattern Recognition · Computer Science 2024-03-12 Zhe Huang , Xiaowei Yu , Benjamin S. Wessler , Michael C. Hughes

In-context Learning (ICL) utilizes structured demonstration-query inputs to induce few-shot learning on Language Models (LMs), which are not originally pre-trained on ICL-style data. To bridge the gap between ICL and pre-training, some…

Computation and Language · Computer Science 2025-09-30 Hakaze Cho , Peng Luo , Mariko Kato , Rin Kaenbyou , Naoya Inoue
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