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The explosion of scientific literature has made the efficient and accurate extraction of structured data a critical component for advancing scientific knowledge and supporting evidence-based decision-making. However, existing tools often…

Human-Computer Interaction · Computer Science 2025-11-06 Xingbo Wang , Samantha L. Huey , Rui Sheng , Saurabh Mehta , Fei Wang

Model biomembrane systems play a crucial role in advancing biomedical research by providing simplified yet effective platforms for exploring complex biological mechanisms. These systems span a wide range of scales, from…

Soft Condensed Matter · Physics 2025-10-01 Ajit Seth , Sajal K. Ghosh , Veerendra K. Sharma

Concurrent advances across fields such as organoid technology, Microelectrode Arrays (MEAs), neuromorphic computing, and machine learning have given rise to a groundbreaking research paradigm: Synthetic Biological Intelligence (SBI). SBI…

Recent advancements in Large Language Models (LLMs) are transforming biology, computer science, engineering, and every day life. However, integrating the wide array of computational tools, databases, and scientific literature continues to…

Healthcare is one of the largest business segments in the world and is a critical area for future growth. In order to ensure efficient access to medical and patient-related information, hospitals have invested heavily in improving clinical…

Computers and Society · Computer Science 2018-07-06 Andrea Marrella , Massimo Mecella , Mahmoud Sharf , Tiziana Catarci

Since the advent of next-generation sequencing in the early 2000s, the volume of bioinformatics software tools and databases has exploded and continues to grow rapidly. Documenting this evolution on a global and time-dependent scale is a…

AI agents are emerging as a practical way to run multi-step scientific workflows that interleave reasoning with tool use and verification, pointing to a shift from isolated AI-assisted steps toward \emph{agentic science at scale}. This…

Operationalizing AI has become a major endeavor in both research and industry. Automated, operationalized pipelines that manage the AI application lifecycle will form a significant part of tomorrow's infrastructure workloads. To optimize…

Distributed, Parallel, and Cluster Computing · Computer Science 2020-06-24 Thomas Rausch , Waldemar Hummer , Vinod Muthusamy

In contemporary biomedical research, the efficiency of data-driven approaches is hindered by large data volumes, tool selection complexity, and human resource limitations, necessitating the development of fully autonomous research systems…

Quantitative Methods · Quantitative Biology 2024-08-13 Luojia Deng , Yijie Wu , Yongyong Ren , Hui Lu

Computational methods have reshaped the landscape of modern biology. While the biomedical community is increasingly dependent on computational tools, the mechanisms ensuring open data, open software, and reproducibility are variably…

Other Quantitative Biology · Quantitative Biology 2020-07-28 Jaqueline J. Brito , Jun Li , Jason H. Moore , Casey S. Greene , Nicole A. Nogoy , Lana X. Garmire , Serghei Mangul

MRI-based medical imaging has become indispensable in modern clinical diagnosis, particularly for brain tumor detection. However, the rapid growth in data volume poses challenges for conventional diagnostic approaches. Although deep…

Computer Vision and Pattern Recognition · Computer Science 2026-03-31 Hayder Saad Abdulbaqi , Mohammed Hadi Rahim , Mohammed Hassan Hadi , Haider Ali Aboud , Ali Hussein Allawi

In this paper, we propose a novel system that integrates state-of-the-art, domain-specific large language models with advanced information retrieval techniques to deliver comprehensive and context-aware responses. Our approach facilitates…

With the advent of Large Language Models (LLMs), medical artificial intelligence (AI) has experienced substantial technological progress and paradigm shifts, highlighting the potential of LLMs to streamline healthcare delivery and improve…

Computation and Language · Computer Science 2024-12-10 Lei Liu , Xiaoyan Yang , Junchi Lei , Yue Shen , Jian Wang , Peng Wei , Zhixuan Chu , Zhan Qin , Kui Ren

Large Language Models (LLMs) have facilitated the definition of autonomous intelligent agents. Such agents have already demonstrated their potential in solving complex tasks in different domains. And they can further increase their…

Software Engineering · Computer Science 2025-06-30 Adem Ait , Javier Luis Cánovas Izquierdo , Jordi Cabot

Context: Empirical Software Engineering (ESE) faces increasing challenges due to data scale, methodological complexity, and reproducibility concerns. Large Language Models (LLMs) have emerged as promising tools to support empirical…

Software Engineering · Computer Science 2026-04-30 Victoria Gomes , Delaney Selb , Fabio Palomba , Rodrigo Spinola , David Lo

LLMs are popular among clinicians for decision-support because of simple text-based interaction. However, their impact on clinicians' performance is ambiguous. Not knowing how clinicians use this new technology and how they compare it to…

Human-Computer Interaction · Computer Science 2026-02-02 Behnam Rahdari , Sameer Shaikh , Jonathan H Chen , Tobias Gerstenberg , Shriti Raj

The recent development of large language models (LLMs) with multi-billion parameters, coupled with the creation of user-friendly application programming interfaces (APIs), has paved the way for automatically generating and executing code in…

Artificial Intelligence · Computer Science 2023-12-14 Alejandro Duque , Abdullah Syed , Kastan V. Day , Matthew J. Berry , Daniel S. Katz , Volodymyr V. Kindratenko

With the rapid development of Large Language Models (LLMs), AI agents have demonstrated increasing proficiency in scientific tasks, ranging from hypothesis generation and experimental design to manuscript writing. Such agent systems are…

Biomedical researchers increasingly rely on large-scale structured databases for complex analytical tasks. However, current text-to-SQL systems often struggle to map qualitative scientific questions into executable SQL, particularly when…

Compound AI systems, orchestrating multiple AI components and external APIs, are increasingly vital but face challenges in managing complexity, handling ambiguity, and enabling effective development workflows. Existing frameworks often…

Artificial Intelligence · Computer Science 2025-04-08 Helena Zhang , Jakobi Haskell , Yosef Frost