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Casimir-Lifshitz forces generate an unavoidable, long-range attraction between protocells under prebiotically realistic conditions. This interaction stabilizes mesoscale clusters such as tetrahedra, octahedra, and 13-cell icosahedra. These…

Soft Condensed Matter · Physics 2026-04-21 Michael Massoth

What is information, physically, and why does it so reliably emerge in living, cultural, and technological systems? Existing theories quantify uncertainty, cost, or compressibility, but do not identify which physical structures count as…

Neurons and Cognition · Quantitative Biology 2025-12-17 Wouter van der Wijngaart

We present a theory of information expressed solely in terms of which transformations of physical systems are possible and which are impossible - i.e. in constructor-theoretic terms. Although it includes conjectured laws of physics that are…

Quantum Physics · Physics 2015-06-19 David Deutsch , Chiara Marletto

The building of minimal self-reproducing systems with a physical embodiment (generically called protocells) is a great challenge, with implications for both theory and applied sciences. Although the classical view of a living protocell…

Cell Behavior · Quantitative Biology 2009-09-29 Harold Fellermann , Ricard V. Solé

We argue for a convergence of crystallography, materials science and biology, that will come about through asking materials questions about biology and biological questions about materials, illuminated by considerations of information. The…

Adaptation and Self-Organizing Systems · Physics 2012-07-18 Julyan H. E. Cartwright , Alan L. Mackay

Computational biology is on the verge of a paradigm shift in its research practice - from a data-based (computational) paradigm to an information-based (cognitive) paradigm. As in the other research fields, this transition is impeded by…

Other Computer Science · Computer Science 2015-05-21 Emanuel Diamant

Pretraining on large, semantically rich datasets is key for developing language models. Surprisingly, recent studies have shown that even synthetic data, generated procedurally through simple semantic-free algorithms, can yield some of the…

Machine Learning · Computer Science 2025-05-29 Zachary Shinnick , Liangze Jiang , Hemanth Saratchandran , Anton van den Hengel , Damien Teney

Traditionally, cognition has been considered a uniquely human capability involving perception, memory, learning, reasoning, and problem-solving. However, recent research shows that cognition is a fundamental ability shared by all living…

Artificial Intelligence · Computer Science 2024-12-03 Gordana Dodig-Crnkovic

Integrated information theory (IIT) argues that the substrate of consciousness is a maximally irreducible complex of units. Together, subsets of the complex specify a cause-effect structure, composed of distinctions and their relations,…

Neurons and Cognition · Quantitative Biology 2025-01-03 William G. P. Mayner , Bjørn Erik Juel , Giulio Tononi

The coexistence between different types of templates has been the choice solution to the information crisis of prebiotic evolution, triggered by the finding that a single RNA-like template cannot carry enough information to code for any…

Populations and Evolution · Quantitative Biology 2007-10-18 Daniel A. M. M. Silvestre , José F. Fontanari

Notions like meaning, signal, intentionality, are difficult to relate to a physical word. I study a purely physical definition of "meaningful information", from which these notions can be derived. It is inspired by a model recently…

History and Philosophy of Physics · Physics 2016-11-09 Carlo Rovelli

Living systems can be understood as organized entities that capture, transform, and reproduce information. Classical gene-centered models explain adaptation through frequency changes driven by differential fitness, yet they often overlook…

Populations and Evolution · Quantitative Biology 2026-01-21 Antonio Carvajal-Rodríguez

A new prior is proposed for learning representations of high-level concepts of the kind we manipulate with language. This prior can be combined with other priors in order to help disentangling abstract factors from each other. It is…

Machine Learning · Computer Science 2019-12-04 Yoshua Bengio

Socio-cognitive action reproduces and changes both social and cognitive structures. The analytical distinction between these dimensions of structure provides us with richer models of scientific development. In this study, I assume that (i)…

Digital Libraries · Computer Science 2015-06-16 Loet Leydesdorff

"Information Processing" is a recently launched buzzword whose meaning is vague and obscure even for the majority of its users. The reason for this is the lack of a suitable definition for the term "information". In my attempt to amend this…

Artificial Intelligence · Computer Science 2013-03-12 Emanuel Diamant

In biological systems, the capacity of anticipation--that is, entertaining a model of the system within the system--can be considered as naturally given. Human languages enable psychological systems to construct and exchange mental models…

Physics and Society · Physics 2009-11-19 Loet Leydesdorff

Psychological and social systems provide us with a natural domain for the study of anticipations because these systems are based on and operate in terms of intentionality. Psychological systems can be expected to contain a model of…

Adaptation and Self-Organizing Systems · Physics 2015-05-14 Loet Leydesdorff

This paper proposes a conceptual framework in which intelligence and consciousness emerge from relational structure rather than from prediction or domain-specific mechanisms. Intelligence is defined as the capacity to form and integrate…

Artificial Intelligence · Computer Science 2026-01-09 Sean Niklas Semmler

The discipline of `theoretical biology' has been developing from its inception several decades ago almost in parallel with the advances in biology, so much so that the latter is often considered to be almost exclusively an empirical…

Biological Physics · Physics 2025-06-10 Shakti N. Menon , Sitabhra Sinha

We extend the concept that life is an informational phenomenon, at every level of organisation, from molecules to the global ecological system. According to this thesis: (a) living is information processing, in which memory is maintained by…

Information Theory · Computer Science 2014-02-17 Keith D. Farnsworth , John Nelson , Carlos Gershenson
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