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Improving the interpretability of brain decoding approaches is of primary interest in many neuroimaging studies. Despite extensive studies of this type, at present, there is no formal definition for interpretability of brain decoding…

Machine Learning · Statistics 2016-06-21 Seyed Mostafa Kia , Andrea Passerini

Encoding and decoding models are widely used in systems, cognitive, and computational neuroscience to make sense of brain-activity data. However, the interpretation of their results requires care. Decoding models can help reveal whether…

Neurons and Cognition · Quantitative Biology 2019-04-29 Nikolaus Kriegeskorte , Pamela K. Douglas

What does a neural network encode about a concept as we traverse through the layers? Interpretability in machine learning is undoubtedly important, but the calculations of neural networks are very challenging to understand. Attempts to see…

Machine Learning · Computer Science 2020-12-14 Zhi Chen , Yijie Bei , Cynthia Rudin

Functional connections in the brain are frequently represented by weighted networks, with nodes representing locations in the brain, and edges representing the strength of connectivity between these locations. One challenge in analyzing…

Applications · Statistics 2022-09-28 Yura Kim , Daniel Kessler , Elizaveta Levina

As the use of artificial intelligence rapidly increases, the development of trustworthy artificial intelligence has become important. However, recent studies have shown that deep neural networks are susceptible to learn spurious…

Computer Vision and Pattern Recognition · Computer Science 2025-07-29 Yooshin Cho , Hanbyel Cho , Janghyeon Lee , HyeongGwon Hong , Jaesung Ahn , Junmo Kim

Brain decoding is a popular multivariate approach for hypothesis testing in neuroimaging. It is well known that the brain maps derived from weights of linear classifiers are hard to interpret because of high correlations between predictors,…

Machine Learning · Statistics 2016-03-30 Seyed Mostafa Kia

Why should we trust the detections of deep neural networks for manipulated faces? Understanding the reasons is important for users in improving the fairness, reliability, privacy and trust of the detection models. In this work, we propose…

Computer Vision and Pattern Recognition · Computer Science 2021-06-22 Yingying Hua , Daichi Zhang , Pengju Wang , Shiming Ge

Recent advancements in medicine have confirmed that brain disorders often comprise multiple subtypes of mechanisms, developmental trajectories, or severity levels. Such heterogeneity is often associated with demographic aspects (e.g., sex)…

Image and Video Processing · Electrical Eng. & Systems 2024-10-08 Magdalini Paschali , Yu Hang Jiang , Spencer Siegel , Camila Gonzalez , Kilian M. Pohl , Akshay Chaudhari , Qingyu Zhao

Addressing the question of visualising human mind could help us to find regions that are associated with observed cognition and responsible for expressing the elusive mental image, leading to a better understanding of cognitive function.…

Neurons and Cognition · Quantitative Biology 2021-02-11 Pan Wang , Rui Zhou , Shuo Wang , Ling Li , Wenjia Bai , Jialu Fan , Chunlin Li , Peter Childs , Yike Guo

Interpretability is crucial to enhance trust in machine learning models for medical diagnostics. However, most state-of-the-art image classifiers based on neural networks are not interpretable. As a result, clinicians often resort to known…

Deep learning is leading to major advances in the realm of brain decoding from functional Magnetic Resonance Imaging (fMRI). However, the large inter-subject variability in brain characteristics has limited most studies to train models on…

Machine Learning · Computer Science 2023-12-12 Alexis Thual , Yohann Benchetrit , Felix Geilert , Jérémy Rapin , Iurii Makarov , Hubert Banville , Jean-Rémi King

The black-box nature of deep learning models has raised concerns about their interpretability for successful deployment in real-world clinical applications. To address the concerns, eXplainable Artificial Intelligence (XAI) aims to provide…

Computer Vision and Pattern Recognition · Computer Science 2024-11-07 Junlin Hou , Jilan Xu , Hao Chen

Interpretability is a critical factor in applying complex deep learning models to advance the understanding of brain disorders in neuroimaging studies. To interpret the decision process of a trained classifier, existing techniques typically…

Image and Video Processing · Electrical Eng. & Systems 2021-06-29 Zixuan Liu , Ehsan Adeli , Kilian M. Pohl , Qingyu Zhao

We consider the setting where many networks are observed on a common node set, and each observation comprises edge weights of a network, covariates observed at each node, and an overall response. The goal is to use the edge weights and node…

Methodology · Statistics 2023-08-23 Daniel Kessler , Keith Levin , Elizaveta Levina

A major prerequisite for the application of machine learning models in clinical decision making is trust and interpretability. Current explainability studies in the neuroimaging community have mostly focused on explaining individual…

Computer Vision and Pattern Recognition · Computer Science 2022-03-25 Fabian Eitel , Anna Melkonyan , Kerstin Ritter

Current Computer-Aided Diagnosis (CAD) methods mainly depend on medical images. The clinical information, which usually needs to be considered in practical clinical diagnosis, has not been fully employed in CAD. In this paper, we propose a…

Image and Video Processing · Electrical Eng. & Systems 2021-03-11 Songxiao Yang , Xiabi Liu , Zhongshu Zheng , Wei Wang , Xiaohong Ma

Cognitive brain imaging is accumulating datasets about the neural substrate of many different mental processes. Yet, most studies are based on few subjects and have low statistical power. Analyzing data across studies could bring more…

Machine Learning · Statistics 2021-05-20 Arthur Mensch , Julien Mairal , Bertrand Thirion , Gaël Varoquaux

An important goal of medical imaging is to be able to precisely detect patterns of disease specific to individual scans; however, this is challenged in brain imaging by the degree of heterogeneity of shape and appearance. Traditional…

When we deploy machine learning models in high-stakes medical settings, we must ensure these models make accurate predictions that are consistent with known medical science. Inherently interpretable networks address this need by explaining…

Computer Vision and Pattern Recognition · Computer Science 2021-10-06 Alina Jade Barnett , Fides Regina Schwartz , Chaofan Tao , Chaofan Chen , Yinhao Ren , Joseph Y. Lo , Cynthia Rudin

Inferring the functional specificity of brain regions from functional Magnetic Resonance Images (fMRI) data is a challenging statistical problem. While the General Linear Model (GLM) remains the standard approach for brain mapping,…

Machine Learning · Computer Science 2012-07-17 Fabian Pedregosa , Alexandre Gramfort , Gaël Varoquaux , Bertrand Thirion , Christophe Pallier , Elodie Cauvet
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